ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN endothelial cell morphogenesis (ortholog); ruffle assembly (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the enco
ded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Acts upstream of or within endothelial cell morphogenesis and ruffle assembly. Is expressed in pons ventricular layer. Orthologous to human ARHGEF26 (Rho guanine nucleotide exchange factor 26). [provided by Alliance of Genome Resources, Jul 2025]
ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN endothelial cell morphogenesis (ortholog); ruffle assembly (ortholog); FOUND IN cell projection (inferred); cytosol (inferred); plasma membrane (inferred)