ARHGEF26 (Rho guanine nucleotide exchange factor 26) - Rat Genome Database

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Gene: ARHGEF26 (Rho guanine nucleotide exchange factor 26) Homo sapiens
Analyze
Symbol: ARHGEF26
Name: Rho guanine nucleotide exchange factor 26
RGD ID: 1603402
HGNC Page HGNC:24490
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within endothelial cell morphogenesis and ruffle assembly. Predicted to be located in cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CSGEF; DKFZp434D146; HMFN1864; Rho guanine nucleotide exchange factor (GEF) 26; SGEF; SH3 domain-containing guanine exchange factor; Src homology 3 domain-containing guanine nucleotide exchange factor; testicular tissue protein Li 171
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383154,121,003 - 154,257,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3154,121,003 - 154,257,827 (+)EnsemblGRCh38hg38GRCh38
GRCh373153,838,792 - 153,975,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363155,321,884 - 155,457,031 (+)NCBINCBI36Build 36hg18NCBI36
Celera3152,256,672 - 152,396,290 (+)NCBICelera
Cytogenetic Map3q25.2NCBI
HuRef3151,230,419 - 151,370,369 (+)NCBIHuRef
CHM1_13153,801,970 - 153,938,825 (+)NCBICHM1_1
T2T-CHM13v2.03156,892,016 - 157,032,100 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
amphotericin B  (EXP)
aristolochic acid A  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
butanal  (EXP)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
dibenz[a,h]anthracene  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
fulvestrant  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glycerol  (EXP)
hydroquinone  (EXP)
ivermectin  (EXP)
lipopolysaccharide  (EXP)
methimazole  (ISO)
methylmercury chloride  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nicotine  (EXP)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propane-1,2-diol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sulforaphane  (ISO)
sunitinib  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell projection  (IEA)
cytosol  (TAS)
ruffle  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12697679   PMID:14702039   PMID:15133129   PMID:15221005   PMID:16344560   PMID:21332407   PMID:21873635   PMID:22383878   PMID:22824926   PMID:23661635   PMID:23775076  
PMID:24399467   PMID:25852190   PMID:26186194   PMID:26764186   PMID:27437949   PMID:28202690   PMID:28514442   PMID:28611215   PMID:28714974   PMID:29454349   PMID:29507755   PMID:30639242  
PMID:31871319   PMID:32203420   PMID:32707033   PMID:32807901   PMID:33961781   PMID:33999101   PMID:34079125   PMID:34242364   PMID:34849650   PMID:35384245  


Genomics

Comparative Map Data
ARHGEF26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383154,121,003 - 154,257,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3154,121,003 - 154,257,827 (+)EnsemblGRCh38hg38GRCh38
GRCh373153,838,792 - 153,975,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363155,321,884 - 155,457,031 (+)NCBINCBI36Build 36hg18NCBI36
Celera3152,256,672 - 152,396,290 (+)NCBICelera
Cytogenetic Map3q25.2NCBI
HuRef3151,230,419 - 151,370,369 (+)NCBIHuRef
CHM1_13153,801,970 - 153,938,825 (+)NCBICHM1_1
T2T-CHM13v2.03156,892,016 - 157,032,100 (+)NCBIT2T-CHM13v2.0
Arhgef26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39362,244,946 - 62,369,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl362,245,765 - 62,369,642 (+)EnsemblGRCm39 Ensembl
GRCm38362,338,777 - 62,462,221 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl362,338,344 - 62,462,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv37362,142,699 - 62,266,143 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36362,426,706 - 62,550,150 (+)NCBIMGSCv36mm8
Celera362,018,356 - 62,139,695 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map329.97NCBI
Arhgef26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82148,889,405 - 149,000,538 (+)NCBIGRCr8
mRatBN7.22146,740,336 - 146,850,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2146,739,631 - 146,850,819 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0227,107,263 - 27,236,336 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,107,318 - 27,236,672 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,226,201 - 46,351,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42151,998,907 - 152,114,966 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2141,079,334 - 141,189,916 (+)NCBICelera
Cytogenetic Map2q31NCBI
Arhgef26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554485,494,571 - 5,627,107 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554485,494,571 - 5,627,107 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22152,032,717 - 152,171,980 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13152,037,453 - 152,176,712 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03151,174,223 - 151,313,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13158,728,629 - 158,865,631 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3158,728,681 - 158,866,019 (+)Ensemblpanpan1.1panPan2
ARHGEF26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12348,290,105 - 48,400,879 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2348,290,104 - 48,399,096 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2348,155,624 - 48,268,098 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02348,918,456 - 49,031,214 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2348,918,746 - 49,031,202 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12348,500,657 - 48,612,000 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02348,556,219 - 48,668,057 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02348,838,156 - 48,950,583 (+)NCBIUU_Cfam_GSD_1.0
Arhgef26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560287,799,054 - 87,892,403 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365191,840,970 - 1,934,905 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365191,841,549 - 1,934,898 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1394,155,872 - 94,289,782 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11394,155,632 - 94,296,699 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213102,204,629 - 102,324,347 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11536,455,968 - 36,595,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1536,455,962 - 36,594,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660419,118,545 - 9,263,011 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473031,716,182 - 31,847,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGEF26
55 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_015595.3(ARHGEF26):c.1487+14983G>A single nucleotide variant Lung cancer [RCV000093102] Chr3:154167915 [GRCh38]
Chr3:153885704 [GRCh37]
Chr3:3q25.2		 uncertain significance
GRCh38/hg38 3q25.1-25.2(chr3:151142354-154931417)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051577]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051577]|See cases [RCV000051577] Chr3:151142354..154931417 [GRCh38]
Chr3:150860141..154649206 [GRCh37]
Chr3:152342831..156131900 [NCBI36]
Chr3:3q25.1-25.2		 pathogenic
GRCh38/hg38 3q24-26.32(chr3:147442566-178522531)x3 copy number gain See cases [RCV000051724] Chr3:147442566..178522531 [GRCh38]
Chr3:147160353..178240319 [GRCh37]
Chr3:148643043..179723013 [NCBI36]
Chr3:3q24-26.32		 pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29		 pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29		 pathogenic
NM_015595.3(ARHGEF26):c.2148T>C (p.Ser716=) single nucleotide variant Malignant melanoma [RCV000065894] Chr3:154240427 [GRCh38]
Chr3:153958216 [GRCh37]
Chr3:155440906 [NCBI36]
Chr3:3q25.2		 not provided
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29		 pathogenic
GRCh38/hg38 3q25.1-29(chr3:152100512-198118383)x3 copy number gain See cases [RCV000139435] Chr3:152100512..198118383 [GRCh38]
Chr3:151818301..197845254 [GRCh37]
Chr3:153300991..199329651 [NCBI36]
Chr3:3q25.1-29		 pathogenic
GRCh38/hg38 3q25.1-25.2(chr3:151429416-155118646)x1 copy number loss See cases [RCV000141813] Chr3:151429416..155118646 [GRCh38]
Chr3:151147204..154836435 [GRCh37]
Chr3:152629894..156319129 [NCBI36]
Chr3:3q25.1-25.2		 likely pathogenic
GRCh37/hg19 3q24-29(chr3:142995020-192997215)x4 copy number gain See cases [RCV000240256] Chr3:142995020..192997215 [GRCh37]
Chr3:3q24-29		 pathogenic
GRCh37/hg19 3q24-26.2(chr3:147180945-168415875)x1 copy number loss See cases [RCV000448130] Chr3:147180945..168415875 [GRCh37]
Chr3:3q24-26.2		 pathogenic
GRCh37/hg19 3q25.2-29(chr3:152356847-197851986)x3 copy number gain See cases [RCV000448608] Chr3:152356847..197851986 [GRCh37]
Chr3:3q25.2-29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
NM_015595.4(ARHGEF26):c.199C>G (p.Gln67Glu) single nucleotide variant Inborn genetic diseases [RCV003286862] Chr3:154122191 [GRCh38]
Chr3:153839980 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.668A>G (p.Gln223Arg) single nucleotide variant Inborn genetic diseases [RCV003305545] Chr3:154122660 [GRCh38]
Chr3:153840449 [GRCh37]
Chr3:3q25.2		 uncertain significance
GRCh37/hg19 3q25.2(chr3:153571286-153915723)x1 copy number loss not provided [RCV000682317] Chr3:153571286..153915723 [GRCh37]
Chr3:3q25.2		 uncertain significance
GRCh37/hg19 3q25.2(chr3:153774569-153845137)x1 copy number loss not provided [RCV000682318] Chr3:153774569..153845137 [GRCh37]
Chr3:3q25.2		 uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
NM_015595.4(ARHGEF26):c.999GAA[3] (p.Lys336del) microsatellite Marfanoid habitus and intellectual disability [RCV000850467] Chr3:154122991..154122993 [GRCh38]
Chr3:153840780..153840782 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1802C>T (p.Pro601Leu) single nucleotide variant Inborn genetic diseases [RCV003246411] Chr3:154194675 [GRCh38]
Chr3:153912464 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.437C>T (p.Pro146Leu) single nucleotide variant Inborn genetic diseases [RCV003292925] Chr3:154122429 [GRCh38]
Chr3:153840218 [GRCh37]
Chr3:3q25.2		 uncertain significance
GRCh37/hg19 3q13.31-26.31(chr3:116620308-172042292)x3 copy number gain not provided [RCV002472621] Chr3:116620308..172042292 [GRCh37]
Chr3:3q13.31-26.31		 pathogenic
GRCh37/hg19 3q22.3-26.1(chr3:138145289-162275610)x3 copy number gain See cases [RCV001194586] Chr3:138145289..162275610 [GRCh37]
Chr3:3q22.3-26.1		 pathogenic
GRCh37/hg19 3q22.3-26.1(chr3:138173683-162494699) copy number gain Global developmental delay [RCV001352648] Chr3:138173683..162494699 [GRCh37]
Chr3:3q22.3-26.1		 pathogenic
GRCh37/hg19 3q24-26.1(chr3:143439359-165252122)x1 copy number loss not provided [RCV001795847] Chr3:143439359..165252122 [GRCh37]
Chr3:3q24-26.1		 pathogenic
GRCh37/hg19 3q23-25.32(chr3:142729607-157921084)x3 copy number gain Brachycephaly [RCV001801182] Chr3:142729607..157921084 [GRCh37]
Chr3:3q23-25.32		 pathogenic
GRCh37/hg19 3q25.1-25.2(chr3:151147204-154845718) copy number loss not specified [RCV002053377] Chr3:151147204..154845718 [GRCh37]
Chr3:3q25.1-25.2		 uncertain significance
GRCh37/hg19 3q24-25.33(chr3:145486960-160504834) copy number gain not specified [RCV002053375] Chr3:145486960..160504834 [GRCh37]
Chr3:3q24-25.33		 pathogenic
NM_015595.4(ARHGEF26):c.1550T>C (p.Ile517Thr) single nucleotide variant Inborn genetic diseases [RCV003252789] Chr3:154187747 [GRCh38]
Chr3:153905536 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1622G>A (p.Arg541Gln) single nucleotide variant Inborn genetic diseases [RCV003304161] Chr3:154187819 [GRCh38]
Chr3:153905608 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.296C>T (p.Pro99Leu) single nucleotide variant Inborn genetic diseases [RCV002777352] Chr3:154122288 [GRCh38]
Chr3:153840077 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2305G>A (p.Glu769Lys) single nucleotide variant Inborn genetic diseases [RCV002946971] Chr3:154253120 [GRCh38]
Chr3:153970909 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2498G>A (p.Arg833Gln) single nucleotide variant Inborn genetic diseases [RCV002974434] Chr3:154255355 [GRCh38]
Chr3:153973144 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1874G>A (p.Arg625Gln) single nucleotide variant Inborn genetic diseases [RCV002974649] Chr3:154217897 [GRCh38]
Chr3:153935686 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.632C>T (p.Ser211Leu) single nucleotide variant Inborn genetic diseases [RCV002905481] Chr3:154122624 [GRCh38]
Chr3:153840413 [GRCh37]
Chr3:3q25.2		 likely benign
NM_015595.4(ARHGEF26):c.2040A>C (p.Gln680His) single nucleotide variant Inborn genetic diseases [RCV002778771] Chr3:154225960 [GRCh38]
Chr3:153943749 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2087A>G (p.Lys696Arg) single nucleotide variant Inborn genetic diseases [RCV002844781] Chr3:154226007 [GRCh38]
Chr3:153943796 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2083A>C (p.Lys695Gln) single nucleotide variant Inborn genetic diseases [RCV002849619] Chr3:154226003 [GRCh38]
Chr3:153943792 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.443G>C (p.Arg148Pro) single nucleotide variant Inborn genetic diseases [RCV002976740] Chr3:154122435 [GRCh38]
Chr3:153840224 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.544A>C (p.Asn182His) single nucleotide variant Inborn genetic diseases [RCV002884630] Chr3:154122536 [GRCh38]
Chr3:153840325 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1216A>G (p.Lys406Glu) single nucleotide variant Inborn genetic diseases [RCV002888933] Chr3:154129666 [GRCh38]
Chr3:153847455 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1025C>G (p.Pro342Arg) single nucleotide variant Inborn genetic diseases [RCV002757181] Chr3:154123017 [GRCh38]
Chr3:153840806 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1260A>T (p.Gln420His) single nucleotide variant Inborn genetic diseases [RCV002799288] Chr3:154129710 [GRCh38]
Chr3:153847499 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.71C>T (p.Pro24Leu) single nucleotide variant Inborn genetic diseases [RCV002661971] Chr3:154122063 [GRCh38]
Chr3:153839852 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1711A>T (p.Met571Leu) single nucleotide variant Inborn genetic diseases [RCV002888418] Chr3:154191359 [GRCh38]
Chr3:153909148 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1381T>A (p.Leu461Met) single nucleotide variant Inborn genetic diseases [RCV002874845] Chr3:154152826 [GRCh38]
Chr3:153870615 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.202G>A (p.Val68Met) single nucleotide variant Inborn genetic diseases [RCV002826336] Chr3:154122194 [GRCh38]
Chr3:153839983 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1930A>G (p.Ile644Val) single nucleotide variant Inborn genetic diseases [RCV002930427] Chr3:154217953 [GRCh38]
Chr3:153935742 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2025G>T (p.Arg675Ser) single nucleotide variant Inborn genetic diseases [RCV002936593] Chr3:154225945 [GRCh38]
Chr3:153943734 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1252T>C (p.Trp418Arg) single nucleotide variant Inborn genetic diseases [RCV002748416] Chr3:154129702 [GRCh38]
Chr3:153847491 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.317C>T (p.Pro106Leu) single nucleotide variant Inborn genetic diseases [RCV002703243] Chr3:154122309 [GRCh38]
Chr3:153840098 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.631T>G (p.Ser211Ala) single nucleotide variant Inborn genetic diseases [RCV002877858] Chr3:154122623 [GRCh38]
Chr3:153840412 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.553C>A (p.Pro185Thr) single nucleotide variant Inborn genetic diseases [RCV002832003] Chr3:154122545 [GRCh38]
Chr3:153840334 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1474G>A (p.Glu492Lys) single nucleotide variant Inborn genetic diseases [RCV002719305] Chr3:154152919 [GRCh38]
Chr3:153870708 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.445A>C (p.Thr149Pro) single nucleotide variant Inborn genetic diseases [RCV002675018] Chr3:154122437 [GRCh38]
Chr3:153840226 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.515C>T (p.Ser172Leu) single nucleotide variant Inborn genetic diseases [RCV003207433] Chr3:154122507 [GRCh38]
Chr3:153840296 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.125G>C (p.Ser42Thr) single nucleotide variant Inborn genetic diseases [RCV003217267] Chr3:154122117 [GRCh38]
Chr3:153839906 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1052A>G (p.Lys351Arg) single nucleotide variant Inborn genetic diseases [RCV003179060] Chr3:154123044 [GRCh38]
Chr3:153840833 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.34A>G (p.Asn12Asp) single nucleotide variant Inborn genetic diseases [RCV003180076] Chr3:154122026 [GRCh38]
Chr3:153839815 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.668A>T (p.Gln223Leu) single nucleotide variant Inborn genetic diseases [RCV003260029] Chr3:154122660 [GRCh38]
Chr3:153840449 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.725C>T (p.Ala242Val) single nucleotide variant Inborn genetic diseases [RCV003341375] Chr3:154122717 [GRCh38]
Chr3:153840506 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.602G>A (p.Gly201Glu) single nucleotide variant Inborn genetic diseases [RCV003342087] Chr3:154122594 [GRCh38]
Chr3:153840383 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.491G>A (p.Gly164Glu) single nucleotide variant Inborn genetic diseases [RCV003344581] Chr3:154122483 [GRCh38]
Chr3:153840272 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2309G>A (p.Arg770Gln) single nucleotide variant Inborn genetic diseases [RCV003366930] Chr3:154253124 [GRCh38]
Chr3:153970913 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2344G>A (p.Gly782Arg) single nucleotide variant Inborn genetic diseases [RCV003366043] Chr3:154253159 [GRCh38]
Chr3:153970948 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.1058A>C (p.Lys353Thr) single nucleotide variant Inborn genetic diseases [RCV003367211] Chr3:154123050 [GRCh38]
Chr3:153840839 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2447T>G (p.Val816Gly) single nucleotide variant Inborn genetic diseases [RCV003361852] Chr3:154254798 [GRCh38]
Chr3:153972587 [GRCh37]
Chr3:3q25.2		 uncertain significance
NM_015595.4(ARHGEF26):c.2297C>T (p.Thr766Met) single nucleotide variant Inborn genetic diseases [RCV003370212] Chr3:154240576 [GRCh38]
Chr3:153958365 [GRCh37]
Chr3:3q25.2		 uncertain significance
Single allele duplication not provided [RCV003448680] Chr3:140154329..197847235 [GRCh37]
Chr3:3q23-29		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2936
Count of miRNA genes:701
Interacting mature miRNAs:785
Transcripts:ENST00000356448, ENST00000465093, ENST00000465817, ENST00000483068, ENST00000496710
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D3S3677  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,944,374 - 153,944,613UniSTSGRCh37
Build 363155,427,064 - 155,427,303RGDNCBI36
Celera3152,365,055 - 152,365,294RGD
Cytogenetic Map3q25.2UniSTS
HuRef3151,339,153 - 151,339,388UniSTS
Marshfield Genetic Map3170.14RGD
Marshfield Genetic Map3170.14UniSTS
Genethon Genetic Map3174.6UniSTS
deCODE Assembly Map3162.79UniSTS
Whitehead-YAC Contig Map3 UniSTS
D3S3058  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,953,840 - 153,954,103UniSTSGRCh37
Build 363155,436,530 - 155,436,793RGDNCBI36
Celera3152,374,521 - 152,374,784RGD
Cytogenetic Map3q25.2UniSTS
HuRef3151,348,615 - 151,348,878UniSTS
Whitehead-RH Map3699.6UniSTS
Whitehead-YAC Contig Map3 UniSTS
SHGC-30578  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,975,469 - 153,975,570UniSTSGRCh37
Build 363155,458,163 - 155,458,264RGDNCBI36
Celera3152,396,143 - 152,396,244RGD
Cytogenetic Map3q25.2UniSTS
HuRef3151,370,222 - 151,370,323UniSTS
GeneMap99-GB4 RH Map3572.79UniSTS
Whitehead-RH Map3702.6UniSTS
GeneMap99-G3 RH Map37514.0UniSTS
RH102541  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,973,908 - 153,974,042UniSTSGRCh37
Build 363155,456,602 - 155,456,736RGDNCBI36
Celera3152,394,580 - 152,394,714RGD
Cytogenetic Map3q25.2UniSTS
HuRef3151,368,660 - 151,368,794UniSTS
GeneMap99-GB4 RH Map3581.64UniSTS
RH119585  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,848,551 - 153,848,660UniSTSGRCh37
Build 363155,331,241 - 155,331,350RGDNCBI36
Celera3152,266,083 - 152,266,192RGD
Cytogenetic Map3q25.2UniSTS
HuRef3151,240,190 - 151,240,299UniSTS
RH123794  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,902,563 - 153,902,843UniSTSGRCh37
Build 363155,385,253 - 155,385,533RGDNCBI36
Celera3152,323,231 - 152,323,511RGD
Cytogenetic Map3q25.2UniSTS
HuRef3151,297,366 - 151,297,646UniSTS
D3S2374  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,842,892 - 153,843,115UniSTSGRCh37
Build 363155,325,582 - 155,325,805RGDNCBI36
Celera3152,260,416 - 152,260,639RGD
Cytogenetic Map3q25.2UniSTS
HuRef3151,234,524 - 151,234,747UniSTS
Stanford-G3 RH Map37044.0UniSTS
Whitehead-YAC Contig Map3 UniSTS
NCBI RH Map31380.8UniSTS
SGEF__5393  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,973,675 - 153,974,472UniSTSGRCh37
Build 363155,456,369 - 155,457,166RGDNCBI36
Celera3152,394,347 - 152,395,145RGD
HuRef3151,368,427 - 151,369,224UniSTS
A004B27  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373153,975,325 - 153,975,518UniSTSGRCh37
Build 363155,458,019 - 155,458,212RGDNCBI36
Celera3152,395,998 - 152,396,192RGD
Cytogenetic Map3q25.2UniSTS
HuRef3151,370,077 - 151,370,271UniSTS
GeneMap99-GB4 RH Map3570.63UniSTS
NCBI RH Map31346.3UniSTS
D8S2279  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map12q24.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map7q21.11UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map6p21.1-p12UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map22q11.22UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map8p23UniSTS
Cytogenetic Map11q13.2-q13.3UniSTS
Cytogenetic Map13q14.1-q14.3UniSTS
Cytogenetic Map3q22-q24UniSTS
Cytogenetic Map3q13.1-q13.2UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic Map17p13.1-p12UniSTS
Cytogenetic Map18q21.33UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map17p12-p11.2UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map1q24UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map2q32UniSTS
Cytogenetic MapXp22.2UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map10q23-q24UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map14q31-q32UniSTS
Cytogenetic Map5p15.33UniSTS
Cytogenetic Map1q23.2UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map2q32.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map4q32.2UniSTS
Cytogenetic Map10q23UniSTS
Cytogenetic Map5q14.2UniSTS
Cytogenetic Map4q32.1UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map11q14.1UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map18p11.31UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map2p22.1UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic MapYp11.2UniSTS
Cytogenetic Map13q13.1UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map18q12UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map3q27.2UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map5p15.2UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map1q42UniSTS
Cytogenetic Map14q32.11UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map5q32-q34UniSTS
Cytogenetic Map15q14UniSTS
Cytogenetic Map16q13UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map3q27.3UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map6q25.3UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map13q14.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map10p12UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map14q21.3UniSTS
Cytogenetic Map8p22-p21UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map12q21.33UniSTS
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map7q21.13UniSTS
Cytogenetic Map7q31.1UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map9q22.3UniSTS
Cytogenetic Map8q13.1UniSTS
Cytogenetic Map3q25UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map1p31.3UniSTS
Cytogenetic Map14q31.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map22q13.31-q13.33UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map7q32.2UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map14q31-q32.1UniSTS
Cytogenetic Map1q42.11UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map2q11.2-q12.1UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map1p22UniSTS
Cytogenetic Map6q16.2UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map2q14UniSTS
Cytogenetic Map20p11.23-p11.21UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map8p11.23UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map8q24.11UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map1q44UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map9q21.32UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map4q21.23UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map22q12.1UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map2q21.3UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map17q22.2UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map12q24.11UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map10q11.1UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map7q34-q35UniSTS
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Cytogenetic Map4q22UniSTS
Cytogenetic Map7p13-p11.1UniSTS
Cytogenetic Map9q31-q34UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic MapXp22.13UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1pUniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map2qUniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map5q14.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map2p24.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map9p21.1UniSTS
Cytogenetic Map9q34.2-q34.3UniSTS
RH93982  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q25.2UniSTS
GeneMap99-GB4 RH Map3570.63UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1760 1225 654 305 120 295 2886 906 1720 49 817 1070 17 1 423 1821 2
Low 658 956 1063 316 495 167 1080 842 2004 310 630 533 157 781 579 2 2
Below cutoff 17 784 9 3 1156 3 391 448 5 51 10 10 388 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_030405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001251962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001251963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047447954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054328655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054328656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054346146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054346147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054346148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB073386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC018452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC207777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF415175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF415176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK022655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK022884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY552599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA248533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB069290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ695204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LS482353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000356448   ⟹   ENSP00000348828
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3154,121,003 - 154,257,827 (+)Ensembl
RefSeq Acc Id: ENST00000465093   ⟹   ENSP00000423418
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3154,121,390 - 154,257,825 (+)Ensembl
RefSeq Acc Id: ENST00000465817   ⟹   ENSP00000423295
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3154,121,440 - 154,257,825 (+)Ensembl
RefSeq Acc Id: ENST00000483068
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3154,225,785 - 154,257,827 (+)Ensembl
RefSeq Acc Id: ENST00000496710   ⟹   ENSP00000424446
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3154,121,416 - 154,256,548 (+)Ensembl
RefSeq Acc Id: NM_001251962   ⟹   NP_001238891
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383154,121,003 - 154,257,825 (+)NCBI
GRCh373153,838,792 - 153,975,616 (+)NCBI
HuRef3151,230,419 - 151,370,369 (+)NCBI
CHM1_13153,801,970 - 153,938,825 (+)NCBI
T2T-CHM13v2.03156,892,016 - 157,032,100 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001251963   ⟹   NP_001238892
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383154,121,390 - 154,257,825 (+)NCBI
GRCh373153,838,792 - 153,975,616 (+)NCBI
HuRef3151,230,419 - 151,370,369 (+)NCBI
CHM1_13153,802,327 - 153,938,825 (+)NCBI
T2T-CHM13v2.03156,892,403 - 157,032,100 (+)NCBI
Sequence:
RefSeq Acc Id: NM_015595   ⟹   NP_056410
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383154,121,390 - 154,257,825 (+)NCBI
GRCh373153,838,792 - 153,975,616 (+)NCBI
Build 363155,321,884 - 155,457,031 (+)NCBI Archive
Celera3152,256,672 - 152,396,290 (+)RGD
HuRef3151,230,419 - 151,370,369 (+)NCBI
CHM1_13153,802,327 - 153,938,825 (+)NCBI
T2T-CHM13v2.03156,892,403 - 157,032,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011512672   ⟹   XP_011510974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383154,121,390 - 154,257,825 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047447954   ⟹   XP_047303910
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383154,121,390 - 154,257,825 (+)NCBI
RefSeq Acc Id: XM_054346146   ⟹   XP_054202121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.03156,892,403 - 157,032,100 (+)NCBI
RefSeq Acc Id: XM_054346147   ⟹   XP_054202122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.03156,892,403 - 157,032,100 (+)NCBI
RefSeq Acc Id: XM_054346148   ⟹   XP_054202123
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.03156,954,338 - 157,032,100 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001238891 (Get FASTA)   NCBI Sequence Viewer  
  NP_001238892 (Get FASTA)   NCBI Sequence Viewer  
  NP_056410 (Get FASTA)   NCBI Sequence Viewer  
  XP_011510974 (Get FASTA)   NCBI Sequence Viewer  
  XP_047303910 (Get FASTA)   NCBI Sequence Viewer  
  XP_054184630 (Get FASTA)   NCBI Sequence Viewer  
  XP_054184631 (Get FASTA)   NCBI Sequence Viewer  
  XP_054202121 (Get FASTA)   NCBI Sequence Viewer  
  XP_054202122 (Get FASTA)   NCBI Sequence Viewer  
  XP_054202123 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH16628 (Get FASTA)   NCBI Sequence Viewer  
  AAH78655 (Get FASTA)   NCBI Sequence Viewer  
  AAL27001 (Get FASTA)   NCBI Sequence Viewer  
  AAL27002 (Get FASTA)   NCBI Sequence Viewer  
  AAS59842 (Get FASTA)   NCBI Sequence Viewer  
  AEE61081 (Get FASTA)   NCBI Sequence Viewer  
  BAB14159 (Get FASTA)   NCBI Sequence Viewer  
  BAB14292 (Get FASTA)   NCBI Sequence Viewer  
  BAD38637 (Get FASTA)   NCBI Sequence Viewer  
  BAG53860 (Get FASTA)   NCBI Sequence Viewer  
  BAG54472 (Get FASTA)   NCBI Sequence Viewer  
  CAB55918 (Get FASTA)   NCBI Sequence Viewer  
  EAW78764 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000348828
  ENSP00000348828.4
  ENSP00000423295.1
  ENSP00000423418
  ENSP00000423418.1
  ENSP00000424446
  ENSP00000424446.1
  ENSP00000481927.1
  ENSP00000484367.1
  ENSP00000486665.1
  ENSP00000487265.1
GenBank Protein Q96DR7 (Get FASTA)   NCBI Sequence Viewer  
  SPT35730 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_056410   ⟸   NM_015595
- Peptide Label: isoform 1
- UniProtKB: Q9H9R2 (UniProtKB/Swiss-Prot),   Q9H9D7 (UniProtKB/Swiss-Prot),   Q96DR6 (UniProtKB/Swiss-Prot),   Q96AW8 (UniProtKB/Swiss-Prot),   Q6Q8Q8 (UniProtKB/Swiss-Prot),   Q6AZ96 (UniProtKB/Swiss-Prot),   Q68CL1 (UniProtKB/Swiss-Prot),   E9PBD0 (UniProtKB/Swiss-Prot),   B3KVP8 (UniProtKB/Swiss-Prot),   Q9UFW5 (UniProtKB/Swiss-Prot),   Q96DR7 (UniProtKB/Swiss-Prot),   A0A140VJU4 (UniProtKB/TrEMBL),   B3KXG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001238891   ⟸   NM_001251962
- Peptide Label: isoform 1
- UniProtKB: Q9H9R2 (UniProtKB/Swiss-Prot),   Q9H9D7 (UniProtKB/Swiss-Prot),   Q96DR6 (UniProtKB/Swiss-Prot),   Q96AW8 (UniProtKB/Swiss-Prot),   Q6Q8Q8 (UniProtKB/Swiss-Prot),   Q6AZ96 (UniProtKB/Swiss-Prot),   Q68CL1 (UniProtKB/Swiss-Prot),   E9PBD0 (UniProtKB/Swiss-Prot),   B3KVP8 (UniProtKB/Swiss-Prot),   Q9UFW5 (UniProtKB/Swiss-Prot),   Q96DR7 (UniProtKB/Swiss-Prot),   A0A140VJU4 (UniProtKB/TrEMBL),   B3KXG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001238892   ⟸   NM_001251963
- Peptide Label: isoform 2
- UniProtKB: B3KXG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011510974   ⟸   XM_011512672
- Peptide Label: isoform X1
- UniProtKB: B3KXG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000423295   ⟸   ENST00000465817
RefSeq Acc Id: ENSP00000423418   ⟸   ENST00000465093
RefSeq Acc Id: ENSP00000424446   ⟸   ENST00000496710
RefSeq Acc Id: ENSP00000348828   ⟸   ENST00000356448
RefSeq Acc Id: XP_047303910   ⟸   XM_047447954
- Peptide Label: isoform X2
- UniProtKB: B3KXG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054202121   ⟸   XM_054346146
- Peptide Label: isoform X1
- UniProtKB: B3KXG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054202122   ⟸   XM_054346147
- Peptide Label: isoform X2
- UniProtKB: B3KXG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054202123   ⟸   XM_054346148
- Peptide Label: isoform X3
Protein Domains
DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96DR7-F1-model_v2 AlphaFold Q96DR7 1-871 view protein structure

Promoters
RGD ID:6866044
Promoter ID:EPDNEW_H6187
Type:initiation region
Name:ARHGEF26_1
Description:Rho guanine nucleotide exchange factor 26
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383154,121,430 - 154,121,490EPDNEW
RGD ID:6801902
Promoter ID:HG_KWN:46515
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour
Transcripts:ENST00000356448,   NM_015595,   UC003EZU.1,   UC003EZV.1,   UC003EZW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 363155,321,516 - 155,322,016 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24490 AgrOrtholog
COSMIC ARHGEF26 COSMIC
Ensembl Genes ENSG00000114790 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000277101 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000356448 ENTREZGENE
  ENST00000356448.8 UniProtKB/Swiss-Prot
  ENST00000465093 ENTREZGENE
  ENST00000465093.6 UniProtKB/Swiss-Prot
  ENST00000465817.1 UniProtKB/Swiss-Prot
  ENST00000496710 ENTREZGENE
  ENST00000496710.5 UniProtKB/Swiss-Prot
  ENST00000614308.3 UniProtKB/Swiss-Prot
  ENST00000618535.3 UniProtKB/Swiss-Prot
  ENST00000629129.2 UniProtKB/Swiss-Prot
  ENST00000630729.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000114790 GTEx
  ENSG00000277101 GTEx
HGNC ID HGNC:24490 ENTREZGENE
Human Proteome Map ARHGEF26 Human Proteome Map
InterPro ARHGEF16/ARHGEF26_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephexin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_ephexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:26084 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26084 ENTREZGENE
OMIM 617552 OMIM
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA166048961 PharmGKB
PROSITE DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VJU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2X0U4M4_HUMAN UniProtKB/TrEMBL
  ARHGQ_HUMAN UniProtKB/Swiss-Prot
  B3KVP8 ENTREZGENE
  B3KXG0 ENTREZGENE, UniProtKB/TrEMBL
  E9PBD0 ENTREZGENE
  Q68CL1 ENTREZGENE
  Q6AZ96 ENTREZGENE
  Q6Q8Q8 ENTREZGENE
  Q96AW8 ENTREZGENE
  Q96DR6 ENTREZGENE
  Q96DR7 ENTREZGENE
  Q9H9D7 ENTREZGENE
  Q9H9R2 ENTREZGENE
  Q9UFW5 ENTREZGENE
UniProt Secondary B3KVP8 UniProtKB/Swiss-Prot
  E9PBD0 UniProtKB/Swiss-Prot
  Q68CL1 UniProtKB/Swiss-Prot
  Q6AZ96 UniProtKB/Swiss-Prot
  Q6Q8Q8 UniProtKB/Swiss-Prot
  Q96AW8 UniProtKB/Swiss-Prot
  Q96DR6 UniProtKB/Swiss-Prot
  Q9H9D7 UniProtKB/Swiss-Prot
  Q9H9R2 UniProtKB/Swiss-Prot
  Q9UFW5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 ARHGEF26  Rho guanine nucleotide exchange factor 26  ARHGEF26  Rho guanine nucleotide exchange factor (GEF) 26  Symbol and/or name change 5135510 APPROVED
2011-07-27 ARHGEF26  Rho guanine nucleotide exchange factor (GEF) 26  SGEF  Src homology 3 domain-containing guanine nucleotide exchange factor  Symbol and/or name change 5135510 APPROVED