| 1321179 | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2 | This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] | 13 | 49444274 | 49495003 | Human | 80 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1614147 | Setdb2 | SET domain, bifurcated 2 | Predicted to enable histone H3K9 methyltransferase activity. Predicted to be involved in several processes, including heterochromatin organization; left/right pattern formation; and negative regulation of macromolecule biosynthetic process. Predicted to be located in cytosol and nucleoplasm. Predict ed to be active in nucleus. Is expressed in several structures, including gonad; nervous system; and nose. Orthologous to human SETDB2 (SET domain bifurcated histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 59639458 | 59678329 | Mouse | 97 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2319564 | Setdb2 | SET domain bifurcated histone lysine methyltransferase 2 | ENCODES a protein that exhibits histone H3K9 methyltransferase activity (ortholog); INVOLVED IN chromosome segregation (ortholog); mitotic cell cycle (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin | 15 | 37731029 | 37782790 | Rat | 77 | symbol , old_gene_name , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 8975019 | Setdb2 | SET domain bifurcated histone lysine methyltransferase 2 | ENCODES a protein that exhibits histone H3K9 methyltransferase activity (ortholog); INVOLVED IN chromosome segregation (ortholog); mitotic cell cycle (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004955431 | 2899849 | 2943091 | Chinchilla | 6 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12044353 | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2 | ENCODES a protein that exhibits DNA binding (inferred); histone H3K9 methyltransferase activity (inferred); histone H3K9me2 methyltransferase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleoplasm (inferred) | 13 | 30584762 | 30635408 | Bonobo | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12124818 | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2 | ENCODES a protein that exhibits DNA binding (inferred); histone H3K9 methyltransferase activity (inferred); histone H3K9me2 methyltransferase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); FOUND IN chromosome (inferred); cytoplasm (inferred); nuclear membrane (inferred) | 22 | 2263990 | 2319249 | Dog | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18661826 | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2 | ENCODES a protein that exhibits DNA binding (inferred); histone H3K9 methyltransferase activity (inferred); histone H3K9me2 methyltransferase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleoplasm (inferred) | | | | Green Monkey | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14162766 | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2 | ENCODES a protein that exhibits DNA binding (inferred); histone H3K9 methyltransferase activity (inferred); histone H3K9me2 methyltransferase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleoplasm (inferred) | | | | Pig | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625869100 | Setdb2 | SET domain bifurcated histone lysine methyltransferase 2 | ENCODES a protein that exhibits histone H3K9 methyltransferase activity (ortholog); INVOLVED IN chromosome segregation (ortholog); mitotic cell cycle (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 6 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155239607 | setdb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155239608 | setdb2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2323619 | Setdb2-ps1 | SET domain bifurcated histone lysine methyltransferase 2, pseudogene 1 | | 20 | 42166822 | 42168114 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 38616362 | SETDB2-PHF11 | SETDB2-PHF11 readthrough | This gene represents naturally-occurring readthrough transcription between the upstream SETDB2 (SET domain bifurcated 2) gene to the downstream PHF11 (PHD finger protein 11) gene. Readthrough transcripts may encode fusion proteins with similarity to proteins enc oded by each of the individual genes or may encode candidates for nonsense-mediated decay (NMD). [provided by RefSeq, Mar 2016] | 13 | 49444274 | 49528976 | Human | | symbol , GTEx , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 18913752 | LOC101696702 | histone-lysine N-methyltransferase SETDB2 | ENCODES a protein that exhibits DNA binding (inferred); histone H3K9 methyltransferase activity (inferred); histone H3K9me2 methyltransferase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); heterochromatin organization (inferred); FOUND IN chromosome (in ferred); cytoplasm (inferred); nuclear membrane (inferred) | | | | Naked Mole-Rat | 25 | ensembl_gene_symbol , name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12527229 | LOC101978403 | histone-lysine N-methyltransferase SETDB2 | ENCODES a protein that exhibits DNA binding (inferred); histone H3K9 methyltransferase activity (inferred); histone H3K9me2 methyltransferase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromosome segregation (inferred); FOUND IN chromosome (inferred ); cytoplasm (inferred); nuclear membrane (inferred) | NW_004936565 | 2536623 | 2607824 | Squirrel | 30 | old_gene_name , name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12795927 | Gm45935 | predicted gene, 45935 | This gene represents naturally-occurring readthrough transcription between the upstream Setdb2 (SET domain, bifurcated 2) gene to the downstream Phf11c (PHD finger protein 11C) gene. Some transcripts may also extend to the Phf11d (PHD finger protein 11D) gene. R eadthrough transcripts may encode fusion proteins with similarity to proteins encoded by each of the individual genes. [provided by RefSeq, Mar 2016] | 14 | 59618282 | 59678329 | Mouse | | old_gene_name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1321995 | PHF11 | PHD finger protein 11 | This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcat ed 2) gene to this locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] | 13 | 49495953 | 49528976 | Human | 109 | description | gene, protein-coding, REVIEWED [RefSeq] |