| 1354487 | SEMA4C | semaphorin 4C | Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in muscle cell differentiation and positive regulation of stress-activated MAPK cascade. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 96859718 | 96870830 | Human | 108 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1558048 | Sema4c | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice t hat bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015] | 1 | 36587720 | 36599780 | Mouse | 111 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1562837 | Sema4c | semaphorin 4C | ENCODES a protein that exhibits semaphorin receptor binding (inferred); INVOLVED IN cell migration in hindbrain (ortholog); cerebellum development (ortholog); muscle cell differentiation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog); postsynaptic density membrane (ortholog); INTERACTS WITH acetamide; bisphenol A; cefaloridine | 9 | 46287540 | 46298041 | Rat | 112 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8861867 | Sema4c | semaphorin 4C | INVOLVED IN cell migration in hindbrain (ortholog); cerebellum development (ortholog); muscle cell differentiation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog); postsynaptic density membrane (ortholog) | NW_004955470 | 4213006 | 4220167 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11668199 | SEMA4C | semaphorin 4C | ENCODES a protein that exhibits chemorepellent activity (inferred); semaphorin receptor binding (inferred); INVOLVED IN axon guidance (inferred); cell differentiation (inferred); cell migration in hindbrain (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasmic vesicle (inferred); glu tamatergic synapse (inferred); plasma membrane (inferred) | 2A | 102443333 | 102455176 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12383111 | SEMA4C | semaphorin 4C | ENCODES a protein that exhibits semaphorin receptor binding (inferred); INVOLVED IN cell differentiation (inferred); cell migration in hindbrain (inferred); cerebellum development (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasmic vesicle (inferred); glutamatergic synapse (inferre d); postsynaptic density (inferred) | 10 | 45105701 | 45116504 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12545920 | Sema4c | semaphorin 4C | ENCODES a protein that exhibits chemorepellent activity (inferred); semaphorin receptor binding (inferred); INVOLVED IN axon guidance (inferred); cell differentiation (inferred); cell migration in hindbrain (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasmic vesicle (inferred); glu tamatergic synapse (inferred); plasma membrane (inferred) | NW_004936744 | 794127 | 804618 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914538 | Sema4c | semaphorin 4C | ENCODES a protein that exhibits chemorepellent activity (inferred); semaphorin receptor binding (inferred); INVOLVED IN cell migration in hindbrain (ortholog); cerebellum development (ortholog); neural tube closure (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN glutamatergic synapse (orth olog); postsynaptic density (ortholog); postsynaptic density membrane (ortholog) | | | | Naked Mole-Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240941 | sema4c | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14117861 | SEMA4C | semaphorin 4C | ENCODES a protein that exhibits semaphorin receptor binding (inferred); INVOLVED IN cell differentiation (inferred); cell migration in hindbrain (inferred); cerebellum development (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasmic vesicle (inferred); glutamatergic synapse (inferre d); postsynaptic density (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625946530 | Sema4c | semaphorin 4C | INVOLVED IN cell migration in hindbrain (ortholog); cerebellum development (ortholog); muscle cell differentiation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog); postsynaptic density membrane (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18543323 | SEMA4C | semaphorin 4C | ENCODES a protein that exhibits chemorepellent activity (inferred); semaphorin receptor binding (inferred); INVOLVED IN axon guidance (inferred); cell differentiation (inferred); cell migration in hindbrain (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasmic vesicle (inferred); glu tamatergic synapse (inferred); plasma membrane (inferred) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253388 | sema4c.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240940 | sema4c.S | | | | | | African Clawed Frog | | symbol | gene, null |