| 1310388 | Sap18 | Sin3A associated protein 18 | ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); positive regulation of apoptotic process (ortholog); regulation of alternative mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN Hedge hog signaling pathway; mRNA decay pathway; RNA transport pathway; FOUND IN ASAP complex (ortholog); cytosol (ortholog); exon-exon junction complex (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 36058784 | 36063089 | Rat | 119 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321265 | SAP18 | Sin3A associated protein 18 | Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, R bAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008] | 13 | 21140119 | 21149097 | Human | 133 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1551528 | Sap18 | Sin3-associated polypeptide 18 | Predicted to enable transcription corepressor activity. Predicted to be involved in positive regulation of apoptotic process and regulation of RNA metabolic process. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear speck . Predicted to be part of ASAP complex; nucleus; and transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; limb; and sensory organ. Orthologous to human SAP18 (Sin3A associated protein 18). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 58035646 | 58042437 | Mouse | 128 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8921737 | Sap18 | Sin3A associated protein 18 | INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); positive regulation of apoptotic process (ortholog); regulation of alternative mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN Hedgehog signaling pathway; FOUND IN ASAP complex (ortholog); cytosol (ortholog); ex on-exon junction complex (ortholog) | NW_004955497 | 1862026 | 1869974 | Chinchilla | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11866958 | SAP18 | Sin3A associated protein 18 | ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); positive regulation of apoptotic process (ortholog); regulation of alternative mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN Hedge hog signaling pathway; FOUND IN ASAP complex (ortholog); cytosol (ortholog); exon-exon junction complex (ortholog) | 13 | 2468402 | 2475504 | Bonobo | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12363054 | SAP18 | Sin3A associated protein 18 | ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); positive regulation of apoptotic process (ortholog); regulation of alternative mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN Hedge hog signaling pathway; FOUND IN ASAP complex (ortholog); cytosol (ortholog); exon-exon junction complex (ortholog) | 25 | 17006025 | 17014948 | Dog | 30 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12511488 | Sap18 | Sin3A associated protein 18 | ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); negative regulation of mRNA splicing, via spliceosome (inferred); PARTICIPATES IN Hedgehog signaling pathw ay; FOUND IN ASAP complex (inferred); cytosol (inferred); exon-exon junction complex (inferred) | NW_004936720 | 610478 | 616529 | Squirrel | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14044757 | SAP18 | Sin3A associated protein 18 | ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); negative regulation of mRNA splicing, via spliceosome (inferred); PARTICIPATES IN Hedgehog signaling pathw ay; FOUND IN ASAP complex (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 32 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18551294 | SAP18 | Sin3A associated protein 18 | ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); negative regulation of mRNA splicing, via spliceosome (inferred); PARTICIPATES IN Hedgehog signaling pathw ay; FOUND IN ASAP complex (inferred); cytosol (inferred); exon-exon junction complex (inferred) | | | | Green Monkey | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18908049 | Sap18 | Sin3A associated protein 18 | ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); positive regulation of apoptotic process (ortholog); regulation of alternative mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN Hedge hog signaling pathway; FOUND IN ASAP complex (ortholog); cytosol (ortholog); exon-exon junction complex (ortholog) | | | | Naked Mole-Rat | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155238926 | sap18 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626063252 | Sap18 | Sin3A associated protein 18 | INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); positive regulation of apoptotic process (ortholog); regulation of alternative mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN Hedgehog signaling pathway; FOUND IN ASAP complex (ortholog); cytosol (ortholog); ex on-exon junction complex (ortholog) | | | | Black Rat | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155259220 | sap18.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249564 | sap18.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1561590 | Sap18-ps1 | Sin3A associated protein 18, pseudogene 1 | PARTICIPATES IN mRNA decay pathway; RNA transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; gentamycin; paracetamol | 10 | 87157579 | 87158204 | Rat | 6 | symbol , old_gene_name , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 10398928 | SAP18P1 | SAP18 pseudogene 1 | | 5 | 76075531 | 76075920 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 9845548 | SAP18P2 | SAP18 pseudogene 2 | | 2 | 181694424 | 181695160 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10402031 | SAP18P3 | SAP18 pseudogene 3 | | 3 | 20007813 | 20008267 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 12010600 | LOC100973107 | histone deacetylase complex subunit SAP18-like | ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); FOUND IN nucleus (inferred) | 2B | 68957082 | 68957774 | Bonobo | 4 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18931727 | LOC101703760 | histone deacetylase complex subunit SAP18-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 12648098 | LOC101966726 | histone deacetylase complex subunit SAP18-like | | NW_004936569 | 1611450 | 1617805 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12735609 | LOC101976963 | histone deacetylase complex subunit SAP18-like | | NW_004936773 | 1092674 | 1093206 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12076518 | LOC102152299 | histone deacetylase complex subunit SAP18-like | | 20 | 13157074 | 13157622 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 625980244 | LOC116887649 | histone deacetylase complex subunit SAP18-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 626160323 | LOC116899993 | histone deacetylase complex subunit SAP18-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18926037 | LOC101709204 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18933698 | LOC101710114 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18934235 | LOC101711981 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18908788 | LOC101715606 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18915954 | LOC101718986 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18928275 | LOC101723872 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18709712 | LOC103217453 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18928467 | LOC110347851 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18921831 | LOC110350097 | histone deacetylase complex subunit SAP18 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 12342020 | LOC475060 | Sin3A associated protein 18 pseudogene | ENCODES a pseudogene that exhibits transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); FOUND IN cytoplasm (inferred); nuclear speck (inferred); nucleus (inferred) | 13 | 4483622 | 4484174 | Dog | 10 | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 14387164 | SAP185 | | | | | | Yeast | | symbol | gene, null |
| 2295704 | Sap18b | Sin3-associated polypeptide 18B | This intronless gene is highly similar to the multi-exon Sap18 gene on chromosome 14, whose product functions in transcriptional repression as a component of the Sin3 histone deacetylase complex. This gene may possibly be a Sap18 span> pseudogene, but it is represented as protein-coding because it appears to be transcribed and has an intact ORF that would result in a protein that is 100% identical to the Sap18 protein. [provided by RefSeq, Dec 2008] | 8 | 96551984 | 96552784 | Mouse | 1 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552420 | Arid4b | AT-rich interaction domain 4B | Predicted to enable transcription cis-regulatory region binding activity. Acts upstream of or within establishment of Sertoli cell barrier; regulation of gene expression; and spermatogenesis. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of Sin3-type comple x. Predicted to be active in nucleus. Is expressed in testis. Orthologous to human ARID4B (AT-rich interaction domain 4B). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 14238334 | 14374188 | Mouse | 183 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1604359 | ARID4B | AT-rich interaction domain 4B | This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis , oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] | 1 | 235166902 | 235328179 | Human | 112 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1354225 | SAP30 | Sin3A associated protein 30 | Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18 >SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008] | 4 | 173370954 | 173377532 | Human | 101 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 619919 | Arid4b | AT-rich interaction domain 4B | ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN chromatin organization (ortholog); establishment of Sertoli cell barrier (ortholog); genomic imprinting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachloro dibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 17 | 55833908 | 55958382 | Rat | 108 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |