| 3245 | S100a4 | S100 calcium-binding protein A4 | ENCODES a protein that exhibits actin binding; calcium ion binding; calcium-dependent protein binding; INVOLVED IN positive regulation of canonical NF-kappaB signal transduction (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH adult respiratory distress syndrom e (ortholog); Colonic Neoplasms (ortholog); intracranial vasospasm (ortholog); FOUND IN extracellular space (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 17beta-estradiol | 2 | 178388529 | 178390838 | Rat | 337 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 69040 | S100A4 | S100 calcium binding protein A4 | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progressi on and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] | 1 | 153543621 | 153545806 | Human | 343 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 69041 | S100a4 | S100 calcium binding protein A4 | Enables calcium ion binding activity and identical protein binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in extracellular space; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; heart; and hemolymphoid system. Orthologous to human S100A4 (S100 calcium binding protein A4). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 90511077 | 90513349 | Mouse | 350 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8884753 | S100a4 | S100 calcium binding protein A4 | ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN positive regulation of canonical NF-kappaB signal transduction (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH a dult respiratory distress syndrome (ortholog); Colonic Neoplasms (ortholog); intracranial vasospasm (ortholog); FOUND IN extracellular space (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955545 | 192236 | 194468 | Chinchilla | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11886538 | S100A4 | S100 calcium binding protein A4 | ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN positive chemotaxis (inferred); positive regulation of canonical NF-kappaB signal transduction (inferred); PARTICIPATES IN calcium/calcium-mediated sign aling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Colonic Neoplasms (ortholog); intracranial vasospasm (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | 1 | 128898765 | 128901042 | Bonobo | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12341163 | S100A4 | S100 calcium binding protein A4 | ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Colonic Neoplasms (ortholog); intracrani al vasospasm (ortholog); FOUND IN nucleoplasm (ortholog); perinuclear region of cytoplasm (ortholog) | 7 | 43494007 | 43496021 | Dog | 47 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12466358 | S100a4 | S100 calcium binding protein A4 | ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN positive chemotaxis (inferred); positive regulation of canonical NF-kappaB signal transduction (inferred); PARTICIPATES IN calcium/calcium-mediated sign aling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Colonic Neoplasms (ortholog); intracranial vasospasm (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | NW_004936580 | 3355751 | 3358030 | Squirrel | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18370335 | S100A4 | S100 calcium binding protein A4 | ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN positive chemotaxis (inferred); positive regulation of canonical NF-kappaB signal transduction (inferred); PARTICIPATES IN calcium/calcium-mediated sign aling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Colonic Neoplasms (ortholog); intracranial vasospasm (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625972182 | S100a4 | S100 calcium binding protein A4 | ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN positive regulation of canonical NF-kappaB signal transduction (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH a dult respiratory distress syndrome (ortholog); Colonic Neoplasms (ortholog); intracranial vasospasm (ortholog); FOUND IN extracellular space (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13928806 | S100A4 | S100 calcium binding protein A4 | ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN positive chemotaxis (inferred); positive regulation of canonical NF-kappaB signal transduction (inferred); PARTICIPATES IN calcium/calcium-mediated sign aling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Colonic Neoplasms (ortholog); intracranial vasospasm (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 54 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18906993 | S100a4 | S100 calcium binding protein A4 | ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN positive regulation of canonical NF-kappaB signal transduction (inferred); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH a dult respiratory distress syndrome (ortholog); Colonic Neoplasms (ortholog); intracranial vasospasm (ortholog); FOUND IN extracellular space (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1320664 | PPFIBP1 | PPFIB scaffold protein 1 | The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It ha s been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | 12 | 27524206 | 27695564 | Human | 226 | description | gene, protein-coding, REVIEWED [RefSeq] |