| 3572 | Rgs9 | regulator of G-protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity; INVOLVED IN G protein-coupled dopamine receptor signaling pathway; negative regulation of NMDA glutamate receptor activity; nervous system development; PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH Parkinsonism; bradyopsia (ortholog); bradyopsia 1 (ortholog); FOUND IN glutamatergic synapse (ortholog); photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3-bis(4-hydroxyphenyl)propionitrile | 10 | 94696556 | 94770387 | Rat | 157 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732260 | RGS9 | regulator of G protein signaling 9 | This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] | 17 | 65137370 | 65227703 | Human | 205 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 736730 | Rgs9 | regulator of G-protein signaling 9 | Predicted to enable GTPase activator activity. Acts upstream of or within dark adaptation and light adaption. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Is expressed in several structures, including central nervous system and retina. Human ortholog(s ) of this gene implicated in bradyopsia 1. Orthologous to human RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 109116174 | 109189013 | Mouse | 206 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8903301 | Rgs9 | regulator of G protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN dark adaptation (ortholog); G protein-coupled dopamine receptor signaling pathway (ortholog); light adaption (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 1 (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN glutamatergic synapse (ortholog); photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | NW_004955478 | 4614730 | 4683152 | Chinchilla | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11796473 | RGS9 | regulator of G protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN dark adaptation (ortholog); G protein-coupled dopamine receptor signaling pathway (ortholog); light adaption (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 1 (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | 17 | 59085707 | 59176368 | Bonobo | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12263689 | RGS9 | regulator of G protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN dark adaptation (ortholog); G protein-coupled dopamine receptor signaling pathway (ortholog); light adaption (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 1 (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | 9 | 14809977 | 14905299 | Dog | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12530920 | Rgs9 | regulator of G protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN dark adaptation (ortholog); G protein-coupled dopamine receptor signaling pathway (ortholog); light adaption (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 1 (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | NW_004936541 | 7472195 | 7525220 | Squirrel | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14045003 | RGS9 | regulator of G protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN dark adaptation (ortholog); G protein-coupled dopamine receptor signaling pathway (ortholog); light adaption (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 1 (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18553849 | RGS9 | regulator of G protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN dark adaptation (ortholog); G protein-coupled dopamine receptor signaling pathway (ortholog); light adaption (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 1 (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | | | | Green Monkey | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929610 | Rgs9 | regulator of G protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN dark adaptation (ortholog); G protein-coupled dopamine receptor signaling pathway (ortholog); light adaption (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 1 (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN glutamatergic synapse (ortholog); photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286162100 | rgs9 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625985637 | Rgs9 | regulator of G protein signaling 9 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN dark adaptation (ortholog); G protein-coupled dopamine receptor signaling pathway (ortholog); light adaption (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 1 (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN glutamatergic synapse (ortholog); photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | | | | Black Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626177013 | rgs9.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 287290918 | rgs9.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1601793 | RGS9BP | regulator of G protein signaling 9 binding protein | The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetram eric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010] | 19 | 32675848 | 32678300 | Human | 77 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1617310 | Rgs9bp | regulator of G-protein signalling 9 binding protein | Acts upstream of or within detection of light stimulus involved in visual perception. Predicted to be located in membrane. Predicted to be active in neuron projection. Is expressed in several structures, including olfactory epithelium and retina. Human ortholog(s) of this gene implicated in bradyops ia 2. Orthologous to human RGS9BP (regulator of G protein signaling 9 binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 35278418 | 35285007 | Mouse | 47 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1561747 | Rgs9bp | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acetamide | 1 | 97386326 | 97387039 | Rat | 45 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8935538 | Rgs9bp | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (ortholog) | NW_004955468 | 5311318 | 5313612 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11930573 | RGS9BP | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (inferred) | 19 | 29595159 | 29597612 | Bonobo | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12164519 | RGS9BP | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (inferred) | 1 | 119316799 | 119322856 | Dog | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12548406 | Rgs9bp | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (inferred) | NW_004936570 | 3042233 | 3043884 | Squirrel | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14168217 | RGS9BP | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (inferred); INTERACTS WITH deoxynivale nol | | | | Pig | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18687184 | RGS9BP | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (inferred) | | | | Green Monkey | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909069 | Rgs9bp | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (inferred) | | | | Naked Mole-Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250099 | rgs9bp | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626102243 | Rgs9bp | regulator of G protein signaling 9 binding protein | INVOLVED IN detection of light stimulus involved in visual perception (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH bradyopsia (ortholog); bradyopsia 2 (ortholog); fundus dystrophy (ortholog); FOUND IN photoreceptor outer segment (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284033227 | rgs9bpl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405855917 | rgs9bp.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860858 | rgs9bp.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861509 | rgs9bp.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861592 | rgs9bp.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469076 | rgs9bp.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250098 | rgs9bp.S | | | | | | African Clawed Frog | | symbol | gene, null |