| 3571 | Rgs8 | regulator of G-protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding; GTPase activator activity; INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; regulation of dopamine receptor signaling pathway; ASSOCIATED WITH Experimental Seizures; FOUND IN cytoplasmic side of plasma membrane; dendrite; neuronal cell body membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil | 13 | 68355078 | 68399412 | Rat | 72 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737105 | RGS8 | regulator of G protein signaling 8 | This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GT P binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008] | 1 | 182641818 | 182752376 | Human | 74 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737106 | Rgs8 | regulator of G-protein signaling 8 | Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and regulation of dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and neuronal cell body membrane. Is expressed in central nervous system and retina. Orthologous to human RGS8 (regulator of G protein signaling 8). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 153528612 | 153573415 | Mouse | 85 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8890241 | Rgs8 | regulator of G protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); positive regulation of GTPase activity (ortholog); regulation of dopamine receptor signaling pathway (o rtholog); ASSOCIATED WITH Experimental Seizures (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); dendrite (ortholog); neuronal cell body membrane (ortholog) | NW_004955406 | 21482810 | 21523518 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11889054 | RGS8 | regulator of G protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); positive regulation of GTPase activity (ortholog); regulation of dopamine receptor signaling pathway (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); neuronal cell body membrane (ortholog) | 1 | 158160368 | 158268521 | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12106704 | RGS8 | regulator of G protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); positive regulation of GTPase activity (ortholog); regulation of dopamine receptor signaling pathway (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); neuronal cell body membrane (ortholog) | 7 | 16053946 | 16081661 | Dog | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12667165 | Rgs8 | regulator of G protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); positive regulation of GTPase activity (ortholog); regulation of dopamine receptor signaling pathway (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); neuronal cell body membrane (ortholog) | NW_004936481 | 7077345 | 7115350 | Squirrel | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13951640 | RGS8 | regulator of G protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); positive regulation of GTPase activity (ortholog); regulation of dopamine receptor signaling pathway (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); neuronal cell body membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285928303 | rgs8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626051929 | Rgs8 | regulator of G protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); positive regulation of GTPase activity (ortholog); regulation of dopamine receptor signaling pathway (o rtholog); ASSOCIATED WITH Experimental Seizures (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); dendrite (ortholog); neuronal cell body membrane (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933743 | Rgs8 | regulator of G protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); positive regulation of GTPase activity (ortholog); regulation of dopamine receptor signaling pathway (o rtholog); ASSOCIATED WITH Experimental Seizures (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); neuronal cell body membrane (ortholog) | | | | Naked Mole-Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18636233 | RGS8 | regulator of G protein signaling 8 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); positive regulation of GTPase activity (ortholog); regulation of dopamine receptor signaling pathway (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); neuronal cell body membrane (ortholog) | | | | Green Monkey | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286245035 | rgs8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284904696 | rgs8.S | | | | | | African Clawed Frog | | symbol | gene, null |