| 3564 | Rgs12 | regulator of G-protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding; GTPase activator activity; GTPase regulator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway; termination of G protein-coupled receptor signaling pathway; PARTICIPATES IN calcium sign aling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite; cytoplasm; dendrite; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 79940561 | 80048637 | Rat | 146 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731521 | RGS12 | regulator of G protein signaling 12 | This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encod ing distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] | 4 | 3285891 | 3439913 | Human | 147 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731522 | Rgs12 | regulator of G-protein signaling 12 | Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in termination of G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including apical dendrite; neuronal cell body; and nuclear lume n. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Predicted to colocalize with synapse. Is expressed in several structures, including heart; nervous system; placenta; trunk; and uterus. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 35106273 | 35196988 | Mouse | 157 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8963976 | Rgs12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); GTPase regulator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling path way (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite (ortholog); cytoplasm (ortholog); dendrite (ortholog) | NW_004955514 | 2081575 | 2154414 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11815516 | RGS12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN calciu m signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite (ortholog); neuronal cell body (ortholog); protein-containing complex (ortholog) | 4 | 3439030 | 3589026 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12155393 | RGS12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN calciu m signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | 3 | 60917033 | 61011812 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12573263 | Rgs12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN calciu m signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite (ortholog); neuronal cell body (ortholog); protein-containing complex (ortholog) | NW_004936477 | 20300528 | 20388212 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284284205 | rgs12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626097398 | Rgs12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); GTPase regulator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling path way (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867193 | RGS12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits GTPase activator activity (inferred); GTPase activity (inferred); GTPase regulator activity (inferred); INVOLVED IN negative regulation of signal transduction (inferred); regulation of G protein-coupled receptor signaling pathway (inferred); FOUND IN cytoplasm (inferr ed); dendrite (inferred); nucleolus (inferred) | | | | Green Monkey | 20 | symbol | gene, protein-coding |
| 18912524 | Rgs12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN calciu m signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite (ortholog); neuronal cell body (ortholog); nucleolus (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14012552 | RGS12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN calciu m signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite (ortholog); dendrite (ortholog); neuronal cell body (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18642217 | RGS12 | regulator of G protein signaling 12 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); GTPase regulator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling path way (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN apical dendrite (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284284135 | rgs12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083494 | rgs12.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 11489712 | Rgs12l1 | regulator of G-protein signaling 12 like 1 | | 14 | 80034401 | 80034874 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |