Rgs12 (regulator of G protein signaling 12) - Rat Genome Database

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Gene: Rgs12 (regulator of G protein signaling 12) Heterocephalus glaber
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Symbol: Rgs12
Name: regulator of G protein signaling 12
RGD ID: 18912524
Description: ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH cherubism (ortholog); Ellis-Van Creveld syndrome (ortholog); fetal akinesia deformation sequence syndrome 1 (ortholog); FOUND IN apical dendrite (ortholog); cytosol (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: regulator of G-protein signaling 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,489,966 - 24,553,505 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,489,746 - 24,567,937 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rgs12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,489,966 - 24,553,505 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,489,746 - 24,567,937 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RGS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3843,285,891 - 3,439,913 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl43,293,021 - 3,439,913 (+)EnsemblGRCh38hg38GRCh38
GRCh3743,287,618 - 3,441,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3643,285,672 - 3,411,438 (+)NCBINCBI36Build 36hg18NCBI36
Build 3443,425,087 - 3,478,607NCBI
Celera43,227,025 - 3,352,526 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef43,253,766 - 3,378,780 (+)NCBIHuRef
CHM1_143,313,437 - 3,439,350 (+)NCBICHM1_1
T2T-CHM13v2.043,284,640 - 3,439,697 (+)NCBIT2T-CHM13v2.0
Rgs12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,106,273 - 35,196,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,106,789 - 35,196,988 (+)EnsemblGRCm39 Ensembl
GRCm38534,948,929 - 35,039,642 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,949,445 - 35,039,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv37535,292,097 - 35,376,244 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36535,266,308 - 35,350,456 (+)NCBIMGSCv36mm8
Celera532,423,269 - 32,508,385 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.96NCBI
Rgs12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,940,561 - 80,048,637 (-)NCBIGRCr8
mRatBN7.21475,715,925 - 75,824,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,715,934 - 75,794,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,175,876 - 80,263,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,416,503 - 81,503,793 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,861,725 - 77,949,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,975,239 - 81,069,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,975,322 - 81,053,906 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,664,122 - 81,771,788 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,363,542 - 81,436,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,365,932 - 81,438,585 (-)NCBI
Celera1474,648,755 - 74,720,676 (-)NCBICelera
Cytogenetic Map14q21NCBI
Rgs12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,088,354 - 2,154,191 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555142,081,575 - 2,154,414 (+)NCBIChiLan1.0ChiLan1.0
RGS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,632,834 - 3,783,631 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,566,200 - 3,717,305 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,439,030 - 3,589,026 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,444,467 - 3,573,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,444,570 - 3,573,712 (+)Ensemblpanpan1.1panPan2
RGS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,917,033 - 61,011,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,917,072 - 61,009,131 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,567,210 - 63,619,308 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,392,603 - 61,512,294 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,392,635 - 61,512,321 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,884,355 - 61,003,999 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,090,461 - 61,208,240 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,446,826 - 61,566,535 (-)NCBIUU_Cfam_GSD_1.0
Rgs12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,544,669 - 66,706,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,257,965 - 20,278,434 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493647720,300,521 - 20,388,221 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,300,528 - 20,388,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,963,308 - 2,075,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,971,390 - 2,074,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,649,955 - 1,729,384 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,302,193 - 45,444,012 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660511,647,849 - 1,802,824 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000023873   ⟹   ENSHGLP00000023655
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475524,489,966 - 24,553,505 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000023874   ⟹   ENSHGLP00000023656
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475524,489,966 - 24,509,515 (-)Ensembl
RefSeq Acc Id: XM_013073113   ⟹   XP_012928567
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475524,493,849 - 24,567,937 (-)NCBI
RefSeq Acc Id: XM_013073115   ⟹   XP_012928569
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475524,495,089 - 24,567,937 (-)NCBI
RefSeq Acc Id: XM_013073116   ⟹   XP_012928570
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475524,493,849 - 24,533,675 (-)NCBI
RefSeq Acc Id: XM_013073117   ⟹   XP_012928571
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475524,489,746 - 24,567,937 (-)NCBI
RefSeq Acc Id: XM_021260361   ⟹   XP_021116020
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475524,493,849 - 24,554,548 (-)NCBI
RefSeq Acc Id: XM_021260362   ⟹   XP_021116021
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475524,495,255 - 24,567,937 (-)NCBI
RefSeq Acc Id: XP_012928571   ⟸   XM_013073117
- Peptide Label: isoform X5
- UniProtKB: G5BZF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928567   ⟸   XM_013073113
- Peptide Label: isoform X1
- UniProtKB: G5BZF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116020   ⟸   XM_021260361
- Peptide Label: isoform X1
- UniProtKB: G5BZF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928570   ⟸   XM_013073116
- Peptide Label: isoform X4
RefSeq Acc Id: XP_012928569   ⟸   XM_013073115
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021116021   ⟸   XM_021260362
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000023656   ⟸   ENSHGLT00000023874
Ensembl Acc Id: ENSHGLP00000023655   ⟸   ENSHGLT00000023873


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016876 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023873 ENTREZGENE
  ENSHGLT00000023874 ENTREZGENE
Gene3D-CATH 1.10.196.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
  Regulator of G-protein Signalling 4, domain 2 UniProtKB/TrEMBL
InterPro GoLoco_motif UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  RBD_dom UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS10/12/14-like UniProtKB/TrEMBL
  RGS12_RGS UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Rgs12 ENTREZGENE
PANTHER REGULATOR OF G-PROTEIN SIGNALING 12 UniProtKB/TrEMBL
  REGULATOR OF G-PROTEIN SIGNALING LOCO UniProtKB/TrEMBL
Pfam GoLoco UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS12_us1 UniProtKB/TrEMBL
  RGS12_us2 UniProtKB/TrEMBL
  RGS12_usC UniProtKB/TrEMBL
PRINTS RGSPROTEIN UniProtKB/TrEMBL
PROSITE GOLOCO UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
SMART GoLoco UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
Superfamily-SCOP PDZ domain-like UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  Regulator of G-protein signaling, RGS UniProtKB/TrEMBL
  Ubiquitin-like UniProtKB/TrEMBL
UniProt G5BZF4 ENTREZGENE, UniProtKB/TrEMBL