| 1311390 | Rfxank | regulatory factor X-associated ankyrin-containing protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras protein signal transduction (ortholog); PARTICIPATES IN antigen processing and presentation pathway; primary immunodeficiency pathway; tuberculosis pathway; ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 16 | 19314307 | 19322827 | Rat | 90 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1322827 | RFXANK | regulatory factor X associated ankyrin containing protein | Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013] | 19 | 19192258 | 19201866 | Human | 180 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322828 | Rfxank | regulatory factor X-associated ankyrin-containing protein | Enables histone deacetylase binding activity. Acts upstream of or within Ras protein signal transduction and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of thi s gene implicated in severe combined immunodeficiency. Orthologous to human RFXANK (regulatory factor X associated ankyrin containing protein). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 70583456 | 70591847 | Mouse | 97 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8982356 | Rfxank | regulatory factor X associated ankyrin containing protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras protein signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955524 | 2635358 | 2642206 | Chinchilla | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11909717 | RFXANK | regulatory factor X associated ankyrin containing protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); histone deacetylase binding (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras protein signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 19 | 18630221 | 18639840 | Bonobo | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12373238 | RFXANK | regulatory factor X associated ankyrin containing protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); histone deacetylase binding (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras protein signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 20 | 43977860 | 43984063 | Dog | 28 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12446790 | Rfxank | regulatory factor X associated ankyrin containing protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); histone deacetylase binding (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras protein signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936596 | 2225423 | 2231504 | Squirrel | 30 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18934324 | Rfxank | regulatory factor X associated ankyrin containing protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras prote in signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN nucleoplasm (ortholog); RNA polymerase II transcription regulator complex (ortholog) | | | | Naked Mole-Rat | 28 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155252260 | rfxank | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626111080 | Rfxank | regulatory factor X associated ankyrin containing protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras protein signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13854957 | RFXANK | regulatory factor X associated ankyrin containing protein | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); histone deacetylase binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras protein signal transduction (orth olog); ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 29 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18742987 | RFXANK | regulatory factor X associated ankyrin containing protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); histone deacetylase binding (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); Ras protein signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); MHC class II deficiency (ortholog); MHC CLASS II DEFICIENCY 1 (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155253173 | rfxank.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1347651 | ANKRA2 | ankyrin repeat family A member 2 | Enables enzyme binding activity and low-density lipoprotein particle receptor binding activity. Involved in regulation of protein-containing complex assembly. Located in 3M complex; cytosol; and membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 73552190 | 73565639 | Human | 105 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1552699 | Ankra2 | ankyrin repeat family A member 2 | Enables histone deacetylase binding activity. Predicted to be involved in regulation of gene expression and regulation of protein-containing complex assembly. Located in cytoplasm; membrane; and nucleus. Is expressed in main olfactory bulb. Orthologous to human ANKRA2 (ankyrin repeat family A member 2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 98399584 | 98411262 | Mouse | 113 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1303108 | Ankra2 | ankyrin repeat family A member 2 | ENCODES a protein that exhibits histone deacetylase binding (ortholog); low-density lipoprotein particle receptor binding (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of protein-containing complex assembly (ortholog); FOUND IN 3M complex (ortholog); cytoplasm (ortholog); cyt osol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 2 | 31347158 | 31358002 | Rat | 100 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8916547 | Ankra2 | ankyrin repeat family A member 2 | ENCODES a protein that exhibits histone deacetylase binding (ortholog); low-density lipoprotein particle receptor binding (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of protein-containing complex assembly (ortholog); FOUND IN 3M complex (ortholog); cytoplasm (ortholog); cyt osol (ortholog) | NW_004955425 | 27035850 | 27045253 | Chinchilla | 22 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |