Rfxank (regulatory factor X-associated ankyrin-containing protein) - Rat Genome Database
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Gene: Rfxank (regulatory factor X-associated ankyrin-containing protein) Mus musculus
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Symbol: Rfxank
Name: regulatory factor X-associated ankyrin-containing protein
RGD ID: 1322828
MGI Page MGI
Description: Exhibits histone deacetylase binding activity. Involved in Ras protein signal transduction and positive regulation of transcription by RNA polymerase II. Localizes to cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to human RFXANK (regulatory factor X associated ankyrin containing protein); PARTICIPATES IN antigen processing and presentation pathway; primary immunodeficiency pathway; tuberculosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ankyrin repeat-containing adapter protein Tvl-1; DNA-binding protein RFXANK; regulatory factor X subunit B; RFX-B; Tv; Tvl1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,583,456 - 70,591,847 (-)NCBIGRCm39mm39
GRCm38870,130,806 - 70,139,197 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,130,794 - 70,139,154 (-)EnsemblGRCm38mm10GRCm38
MGSCv37872,654,705 - 72,663,096 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,059,795 - 73,068,186 (-)NCBImm8
Celera872,686,245 - 72,694,635 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:9806546   PMID:10329666   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11095640   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15964851  
PMID:16141072   PMID:16141073   PMID:16236793   PMID:16602821   PMID:18287559   PMID:18799693   PMID:20059953   PMID:20211142   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Rfxank
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,583,456 - 70,591,847 (-)NCBIGRCm39mm39
GRCm38870,130,806 - 70,139,197 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,130,794 - 70,139,154 (-)EnsemblGRCm38mm10GRCm38
MGSCv37872,654,705 - 72,663,096 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,059,795 - 73,068,186 (-)NCBImm8
Celera872,686,245 - 72,694,635 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
RFXANK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1919,192,229 - 19,201,869 (+)EnsemblGRCh38hg38GRCh38
GRCh381919,192,258 - 19,201,869 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371919,303,008 - 19,312,678 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361919,164,008 - 19,173,678 (+)NCBINCBI36hg18NCBI36
Build 341919,164,007 - 19,173,678NCBI
Celera1919,207,811 - 19,217,474 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,866,779 - 18,876,442 (+)NCBIHuRef
CHM1_11919,303,524 - 19,313,189 (+)NCBICHM1_1
Rfxank
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01621,029,449 - 21,037,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,029,596 - 21,037,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,879,055 - 20,886,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,764,913 - 19,772,281 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,764,910 - 19,772,277 (+)NCBI
Celera1619,469,978 - 19,477,481 (+)NCBICelera
Cytogenetic Map16p14NCBI
Rfxank
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,635,358 - 2,641,765 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,635,358 - 2,642,206 (-)NCBIChiLan1.0ChiLan1.0
RFXANK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,631,847 - 19,640,622 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,631,847 - 19,640,619 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,630,221 - 18,639,840 (+)NCBIMhudiblu_PPA_v0panPan3
RFXANK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2043,977,867 - 43,983,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12043,977,860 - 43,984,063 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rfxank
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,225,423 - 2,231,504 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RFXANK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,677,534 - 58,683,882 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,677,534 - 58,684,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RFXANK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,657,069 - 17,669,872 (+)NCBI
ChlSab1.1 Ensembl617,657,942 - 17,671,417 (+)Ensembl
Rfxank
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249082,090,127 - 2,095,446 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1213
Count of miRNA genes:590
Interacting mature miRNAs:709
Transcripts:ENSMUST00000075724
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000075724   ⟹   ENSMUSP00000075140
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,130,806 - 70,139,154 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211970
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,130,794 - 70,135,628 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212320   ⟹   ENSMUSP00000148739
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,133,266 - 70,139,096 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212472
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,134,440 - 70,135,627 (-)Ensembl
RefSeq Acc Id: NM_001025589   ⟹   NP_001020760
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,583,456 - 70,591,847 (-)NCBI
GRCm38870,130,806 - 70,139,197 (-)ENTREZGENE
MGSCv37872,654,705 - 72,663,096 (-)RGD
Celera872,686,245 - 72,694,635 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011266   ⟹   NP_035396
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,583,456 - 70,591,847 (-)NCBI
GRCm38870,130,806 - 70,139,197 (-)ENTREZGENE
MGSCv37872,654,705 - 72,663,096 (-)RGD
Celera872,686,245 - 72,694,635 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035396   ⟸   NM_011266
- Peptide Label: isoform 1
- UniProtKB: Q9Z205 (UniProtKB/Swiss-Prot),   Q53X17 (UniProtKB/TrEMBL),   Q543F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001020760   ⟸   NM_001025589
- Peptide Label: isoform 2
- UniProtKB: Q9Z205 (UniProtKB/Swiss-Prot),   Q543F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000075140   ⟸   ENSMUST00000075724
RefSeq Acc Id: ENSMUSP00000148739   ⟸   ENSMUST00000212320
Protein Domains
ANK_REP_REGION

Promoters
RGD ID:8667277
Promoter ID:EPDNEW_M11670
Type:initiation region
Name:Rfxank_1
Description:Mus musculus regulatory factor X-associated ankyrin-containingprotein , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,139,125 - 70,139,185EPDNEW
RGD ID:6848339
Promoter ID:MM_ACW:47810
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:RFXANK.GSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,657,071 - 72,657,571 (-)MPROMDB
RGD ID:6843676
Promoter ID:MM_KWN:54663
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001025589,   NM_011266
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,662,911 - 72,663,707 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333865 AgrOrtholog
Ensembl Genes ENSMUSG00000036120 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000075140 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148739 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000075724 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000212320 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-bd_RFXANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19727 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1333865 ENTREZGENE
NCBI Gene 19727 ENTREZGENE
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rfxank PhenoGen
PIRSF DNA-binding_RFXANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.161167 ENTREZGENE
UniProt Q3UK69_MOUSE UniProtKB/TrEMBL
  Q53X17 ENTREZGENE, UniProtKB/TrEMBL
  Q543F0 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z205 ENTREZGENE, UniProtKB/Swiss-Prot