| 1304612 | Rasgrp3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); kinase binding (ortholog); INVOLVED IN Ras protein signal transduction (ortholog); PARTICIPATES IN B cell receptor signaling pathway; mitogen activated protein kinase signalin g pathway; ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholog); systemic lupus erythematosus (ortholog); FOUND IN cytoplasm (ortholog); guanyl-nucleotide exchange factor complex (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil | 6 | 25647386 | 25745952 | Rat | 137 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1312152 | RASGRP3 | RAS guanyl releasing protein 3 | The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017] | 2 | 33436348 | 33564731 | Human | 142 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1312153 | Rasgrp3 | RAS, guanyl releasing protein 3 | Enables guanyl-nucleotide exchange factor activity; kinase binding activity; and small GTPase binding activity. Acts upstream of or within Ras protein signal transduction. Located in perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is expressed in cerebral cortex v entricular layer; embryo; and thymus primordium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 75742849 | 75836049 | Mouse | 150 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8764700 | Rasgrp3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); kinase binding (ortholog); INVOLVED IN Ras protein signal transduction (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholog); s ystemic lupus erythematosus (ortholog); FOUND IN cytoplasm (ortholog); guanyl-nucleotide exchange factor complex (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004955441 | 1679258 | 1786397 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11839707 | RASGRP3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits calcium ion binding (inferred); GTPase activator activity (inferred); GTPase regulator activity (inferred); INVOLVED IN Ras protein signal transduction (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholog); systemic lupu s erythematosus (ortholog); FOUND IN cytoplasm (inferred); guanyl-nucleotide exchange factor complex (inferred); perinuclear region of cytoplasm (inferred) | 2A | 33444941 | 33572829 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12268864 | RASGRP3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits calcium ion binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN Ras protein signal transduction (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholo g); systemic lupus erythematosus (ortholog); FOUND IN cytoplasm (inferred); guanyl-nucleotide exchange factor complex (inferred); perinuclear region of cytoplasm (inferred) | 17 | 26560832 | 26657276 | Dog | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12595452 | Rasgrp3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits calcium ion binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN Ras protein signal transduction (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholo g); systemic lupus erythematosus (ortholog); FOUND IN cytoplasm (inferred); guanyl-nucleotide exchange factor complex (inferred); perinuclear region of cytoplasm (inferred) | NW_004936493 | 103937 | 205819 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239507 | rasgrp3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14277851 | RASGRP3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits calcium ion binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN Ras protein signal transduction (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholo g); systemic lupus erythematosus (ortholog); FOUND IN cytoplasm (inferred); guanyl-nucleotide exchange factor complex (inferred); perinuclear region of cytoplasm (inferred) | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934237 | Rasgrp3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits GTPase activator activity (ortholog); kinase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN Ras protein signal transduction (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholog); systemic lupus erythema tosus (ortholog); FOUND IN cytoplasm (ortholog); guanyl-nucleotide exchange factor complex (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626123622 | Rasgrp3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); kinase binding (ortholog); INVOLVED IN Ras protein signal transduction (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholog); s ystemic lupus erythematosus (ortholog); FOUND IN cytoplasm (ortholog); guanyl-nucleotide exchange factor complex (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18574093 | RASGRP3 | RAS guanyl releasing protein 3 | ENCODES a protein that exhibits calcium ion binding (inferred); GTPase activator activity (inferred); GTPase regulator activity (inferred); INVOLVED IN Ras protein signal transduction (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholog); systemic lupu s erythematosus (ortholog); FOUND IN cytoplasm (inferred); guanyl-nucleotide exchange factor complex (inferred); perinuclear region of cytoplasm (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244930 | rasgrp3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239506 | rasgrp3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 21410006 | RASGRP3-AS1 | RASGRP3 antisense RNA 1 | | 2 | 33555045 | 33569430 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 5131968 | Rasgrp3em1Mcwi | RAS guanyl releasing protein 3 (calcium and DAG-regulated); zinc finger nuclease induced mutant 1, Medical College of Wisconsin | This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an 5-bp frameshift deletion in exon 12 (del 1501-1503, ins. Ttaggtgg). | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 5143946 | Rasgrp3em3Mcwi | RAS guanyl releasing protein 3 (calcium and DAG-regulated); zinc finger nuclease induced mutant 3, Medical College of Wisconsin | This allele was made using ZFN mutagenesis. The resulting mutation is a 20-bp frameshift deletion in exon 12 (del 1494-1513) | | | | Rat | | symbol , old_gene_symbol | gene, allele |