| 14376881 | qars-1 | | | | | | Roundworm | | symbol | gene, null |
| 1322145 | EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008] | 1 | 219968600 | 220046505 | Human | 301 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1346181 | QARS1 | glutaminyl-tRNA synthetase 1 | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans , 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] | 3 | 49095932 | 49104757 | Human | 214 | symbol , ensembl_gene_symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1359448 | Qars1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits glutamine-tRNA ligase activity (ortholog); protein kinase binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN brain development (ortholog); glutaminyl-tRNA aminoacylation (ortholog); negative regulation of apoptotic signaling pathway (ortholo g); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH sciatic neuropathy; attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride | 8 | 118086243 | 118094274 | Rat | 153 | symbol , ensembl_gene_symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1550740 | Qars1 | glutaminyl-tRNA synthetase 1 | Predicted to enable several functions, including glutamine-tRNA ligase activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to be involved in several processes, including glutaminyl-tRNA aminoacylation; negative regulation of macromolecule metabolic process; an d negative regulation of signal transduction. Predicted to act upstream of or within negative regulation of apoptotic process. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 108385204 | 108393140 | Mouse | 164 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8799028 | Qars1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits glutamine-tRNA ligase activity (ortholog); protein kinase binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN brain development (ortholog); glutaminyl-tRNA aminoacylation (ortholog); negative regulation of apoptotic signaling pathway (ortholo g); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955532 | 1093444 | 1100591 | Chinchilla | 35 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12044085 | QARS1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN brain development (ortholog); negative regulation of apoptotic signaling pathway (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN 2-h ydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN protein-containing complex (ortholog) | 3 | 49020310 | 49029443 | Bonobo | 49 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12087643 | QARS1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); glutamine-tRNA ligase activity (inferred); INVOLVED IN brain development (inferred); glutaminyl-tRNA aminoacylation (inferred); negative regulation of apoptotic signaling pathway (inferred); PARTICIPAT ES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | 20 | 40077856 | 40085100 | Dog | 54 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12509754 | Qars1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); glutamine-tRNA ligase activity (inferred); INVOLVED IN brain development (inferred); glutaminyl-tRNA aminoacylation (inferred); negative regulation of apoptotic signaling pathway (inferred); PARTICIPAT ES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936529 | 802753 | 810270 | Squirrel | 54 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18503825 | QARS1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); glutamine-tRNA ligase activity (inferred); INVOLVED IN brain development (inferred); glutaminyl-tRNA aminoacylation (inferred); negative regulation of apoptotic signaling pathway (inferred); PARTICIPAT ES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 54 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926558 | Qars1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN brain development (ortholog); negative regulation of apoptotic signaling pathway (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN 2-h ydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Naked Mole-Rat | 49 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14226868 | QARS1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); glutamine-tRNA ligase activity (inferred); INVOLVED IN brain development (inferred); glutaminyl-tRNA aminoacylation (inferred); negative regulation of apoptotic signaling pathway (inferred); PARTICIPAT ES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 54 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 626015559 | Qars1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits glutamine-tRNA ligase activity (ortholog); protein kinase binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN brain development (ortholog); glutaminyl-tRNA aminoacylation (ortholog); negative regulation of apoptotic signaling pathway (ortholo g); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245595 | qars1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155245596 | qars1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255707 | qars1.S | | | | | | African Clawed Frog | | symbol | gene, null |
