| 1349944 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008] | 4 | 86594315 | 86815161 | Human | 203 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557469 | Ptpn13 | protein tyrosine phosphatase, non-receptor type 13 | Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including negative regulation of excitatory synapse assembly; peptidyl-tyrosine dephosphorylation; and regulation of phospha tidylinositol 3-kinase/protein kinase B signal transduction. Located in cytoplasm; midbody; and nucleus. Is expressed in several structures, including brain; epithelium; genitourinary system; gut; and humerus cartilage condensation. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and colorectal cancer (multiple). Orthologous to human PTPN13 (protein tyrosine phosphatase non-receptor type 13). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 103573058 | 103746227 | Mouse | 202 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1563360 | Ptpn13 | protein tyrosine phosphatase, non-receptor type 13 | ENCODES a protein that exhibits phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN cellular response to toxic substance; negative regulation of excitatory synapse assembly; negative regulation of protein phosphorylation; PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH transient cerebral ischemia; breast cancer (ortholog); colon cancer (ortholog); FOUND IN cell body; cytoplasm (ortholog); lamellipodium (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 6412841 | 6587238 | Rat | 193 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8923499 | Ptpn13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholog); negative regulation of pr otein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); lamellipodium (ortholog) | NW_004955474 | 2988109 | 3140520 | Chinchilla | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11714007 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholo g); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog) | 4 | 78893598 | 79118745 | Bonobo | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12079637 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholo g); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog); INTERACTS WITH bisphenol A | 32 | 10125447 | 10328764 | Dog | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12690157 | Ptpn13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholo g); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog) | NW_004936920 | 313762 | 510334 | Squirrel | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625848696 | Ptpn13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholog); negative regulation of pr otein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); lamellipodium (ortholog) | | | | Black Rat | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13892215 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholo g); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18401050 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholo g); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog) | | | | Green Monkey | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911115 | Ptpn13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholo g); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237158 | ptpn13 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155237159 | ptpn13.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1348546 | PRY | PTPN13 like Y-linked | This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more telomeric copy. [provided by RefSeq, Aug 2024] | Y | 22490397 | 22514637 | Human | 9 | old_gene_name , name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1349286 | PRY2 | PTPN13 like Y-linked 2 | This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more centromeric copy. [provided by RefSeq, Aug 2024] | Y | 22071706 | 22084875 | Human | 9 | old_gene_name , name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 329347040 | LOC129395554 | PTPN13 like Y-linked pseudogene | | | | | Bonobo | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 329345017 | LOC129395579 | PTPN13 like Y-linked pseudogene | | | | | Bonobo | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 2291812 | PRYP1 | PTPN13 like Y-linked pseudogene 1 | | Y | 17729799 | 17744540 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 2291811 | PRYP2 | PTPN13 like Y-linked pseudogene 2 | | Y | 18161364 | 18177051 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 2291810 | PRYP3 | PTPN13 like Y-linked pseudogene 3 | | Y | 23681340 | 23694681 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 2291809 | PRYP4 | PTPN13 like Y-linked pseudogene 4 | | Y | 25975395 | 25988736 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 10400078 | PRYP5 | PTPN13 like Y-linked pseudogene 5 | | Y | 18529258 | 18529723 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 10413234 | PRYP6 | PTPN13 like Y-linked pseudogene 6 | | Y | 18790609 | 18791151 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 1320479 | Brd7 | bromodomain containing 7 | Enables transcription corepressor activity. Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle and regulation of gene expression. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and to oth. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 89056522 | 89089249 | Mouse | 158 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1342986 | RBMY1E | RNA binding motif protein Y-linked family 1 member E | This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008] | Y | 21902177 | 21918032 | Human | 20 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1352327 | RBMY1F | RNA binding motif protein Y-linked family 1 member F | This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008] | Y | 22162885 | 22182923 | Human | 21 | description | gene, protein-coding, REVIEWED [RefSeq] |
