| 1307428 | Psmb10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH Experimen tal Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN proteasome core complex (ortholog); spermatoproteasome complex (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol | 19 | 50740808 | 50743292 | Rat | 192 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316619 | PSMB10 | proteasome 20S subunit beta 10 | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throug hout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008] | 16 | 67934506 | 67936850 | Human | 265 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316620 | Psmb10 | proteasome (prosome, macropain) subunit, beta type 10 | Predicted to enable endopeptidase activity. Acts upstream of or within T cell proliferation and cell morphogenesis. Part of proteasome core complex and spermatoproteasome complex. Is expressed in several structures, including adrenal gland; cerebral cortex; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in immunodeficiency 121 and proteosome-associated autoinflammatory syndrome 5. Orthologous to human PSMB10 (proteasome 20S subunit beta 10). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 106662360 | 106665024 | Mouse | 226 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9004067 | Psmb10 | proteasome 20S subunit beta 10 | INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN proteasome core complex (ortholog); spermatoproteasome complex (o rtholog) | NW_004955484 | 8777618 | 8780393 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11729096 | PSMB10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | 16 | 48275764 | 48278108 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12203000 | PSMB10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | 5 | 81560750 | 81563571 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12717171 | Psmb10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | NW_004936475 | 18290055 | 18293035 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907195 | Psmb10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Naked Mole-Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14296879 | PSMB10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Pig | 26 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18448519 | PSMB10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625836465 | Psmb10 | proteasome 20S subunit beta 10 | INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN proteasome core complex (ortholog); spermatoproteasome complex (o rtholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 2291820 | PSMB11 | proteasome subunit beta 11 | Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008] | 14 | 23042212 | 23044060 | Human | 50 | description | gene, protein-coding, VALIDATED [RefSeq] |
