| 620968 | Prkcq | protein kinase C, theta | ENCODES a protein that exhibits protein serine/threonine kinase activity; diacylglycerol-dependent serine/threonine kinase activity (ortholog); diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); INVOLVED IN intracellular signal transduction; neuron differentia tion; positive regulation of filopodium assembly; PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Hyperammonemia; hyperinsulinism; Insulin Resistance; FOUND IN neuromuscular junction; sarcolemma; centriolar satellite (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 17 | 72156215 | 72288508 | Rat | 224 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1350580 | PRKCQ | protein kinase C theta | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC f amily members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008] | 10 | 6394097 | 6580646 | Human | 221 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1551360 | Prkcq | protein kinase C, theta | Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including positive regulation of T-helper 17 type immune response; regulation of cell-cell adhesion; and regulation of gene expression. Acts upstream of or within several processes, including positive r egulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of interleukin-2 production; and protein phosphorylation. Located in cytoplasm and immunological synapse. Is expressed in several structures, including adipose tissue; genitourinary system; gut; limb; and nervous system. Used to study retinal detachment. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 11176922 | 11306033 | Mouse | 303 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8856685 | Prkcq | protein kinase C theta | ENCODES a protein that exhibits diacylglycerol-dependent serine/threonine kinase activity (ortholog); diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN cell chemotaxis (ortholog); intracellular signal transducti on (ortholog); membrane protein ectodomain proteolysis (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN centriolar satellite (ortholog); cytoplasm (ortholog); immunological synapse (ortholog) | NW_004955421 | 23072607 | 23151591 | Chinchilla | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11726494 | PRKCQ | protein kinase C theta | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN intracellular signal transduction (ortholog); neuron differentiation (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN neuromuscular junction (ortholog); sarcolemma (ortholog) | 10 | 6458138 | 6610781 | Bonobo | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12223438 | PRKCQ | protein kinase C theta | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN intracellular signal transduction (ortholog); neuron differentiation (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN neuromuscular junction (ortholog); sarcolemma (ortholog) | 2 | 29319123 | 29505338 | Dog | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12569474 | Prkcq | protein kinase C theta | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN intracellular signal transduction (ortholog); neuron differentiation (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN neuromuscular junction (ortholog); sarcolemma (ortholog) | NW_004936484 | 8048239 | 8166058 | Squirrel | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257625 | prkcq | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18932932 | Prkcq | protein kinase C theta | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cell chemotaxis (ortholog); intracellular signal transduction (ortholog); negative regulation of insulin recepto r signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN centriolar satellite (ortholog); neuromuscular junction (ortholog); sarcolemma (ortholog) | | | | Naked Mole-Rat | 91 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626011265 | Prkcq | protein kinase C theta | ENCODES a protein that exhibits diacylglycerol-dependent serine/threonine kinase activity (ortholog); diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN cell chemotaxis (ortholog); intracellular signal transducti on (ortholog); membrane protein ectodomain proteolysis (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN centriolar satellite (ortholog); cytoplasm (ortholog); immunological synapse (ortholog) | | | | Black Rat | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18792876 | PRKCQ | protein kinase C theta | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN intracellular signal transduction (ortholog); neuron differentiation (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN neuromuscular junction (ortholog); sarcolemma (ortholog) | | | | Green Monkey | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13978724 | PRKCQ | protein kinase C theta | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN intracellular signal transduction (ortholog); neuron differentiation (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN neuromuscular junction (ortholog); sarcolemma (ortholog) | | | | Pig | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240308 | prkcq.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 7177053 | PRKCQ-AS1 | PRKCQ antisense RNA 1 | INTERACTS WITH all-trans-retinoic acid; benzo[a]pyrene; cadmium dichloride | 10 | 6580425 | 6585361 | Human | 15 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |