Prkcq (protein kinase C theta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prkcq (protein kinase C theta) Heterocephalus glaber
Analyze
Symbol: Prkcq
Name: protein kinase C theta
RGD ID: 18932932
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell proliferation (ortholog); intracellular signal transduction (ortholog); neuron differentiation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Hyperammonemia (ortholog); hyperinsulinism (ortholog); FOUND IN neuromuscular junction (ortholog); sarcolemma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein kinase C theta type
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247751,419,509 - 1,502,064 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247751,419,596 - 1,543,805 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
CD4-positive, alpha-beta T cell proliferation  (IEA,ISO)
cell chemotaxis  (IEA)
intracellular signal transduction  (IEA,ISO)
membrane protein ectodomain proteolysis  (IEA)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of T cell apoptotic process  (IEA)
neuron differentiation  (ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (IEA,ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of interleukin-17 production  (IEA)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of interleukin-4 production  (IEA)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of T cell activation  (IEA,ISO)
positive regulation of T-helper 17 type immune response  (IEA)
positive regulation of T-helper 2 cell activation  (IEA)
positive regulation of telomere maintenance  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of G2/M transition of mitotic cell cycle  (ISO)
regulation of platelet aggregation  (IEA)
regulation of vasoconstriction  (ISO)
respiratory burst  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to organic cyclic compound  (ISO)
T cell activation  (IEA,ISO)
tissue regeneration  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prkcq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247751,419,509 - 1,502,064 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247751,419,596 - 1,543,805 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PRKCQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38106,394,097 - 6,580,646 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl106,427,143 - 6,580,301 (-)EnsemblGRCh38hg38GRCh38
GRCh37106,436,059 - 6,622,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36106,509,111 - 6,662,244 (-)NCBINCBI36Build 36hg18NCBI36
Build 34106,509,110 - 6,662,244NCBI
Celera106,391,714 - 6,479,754 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef106,388,053 - 6,541,112 (-)NCBIHuRef
CHM1_1106,468,923 - 6,622,208 (-)NCBICHM1_1
T2T-CHM13v2.0106,394,273 - 6,580,768 (-)NCBIT2T-CHM13v2.0
Prkcq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,176,922 - 11,306,033 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl211,176,919 - 11,306,033 (+)EnsemblGRCm39 Ensembl
GRCm38211,171,905 - 11,301,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,172,108 - 11,301,222 (+)EnsemblGRCm38mm10GRCm38
MGSCv37211,094,009 - 11,222,853 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36211,090,235 - 11,219,079 (+)NCBIMGSCv36mm8
Celera211,093,754 - 11,222,740 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.42NCBI
Prkcq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81772,156,215 - 72,288,508 (-)NCBIGRCr8
mRatBN7.21767,246,394 - 67,379,049 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1767,246,394 - 67,378,704 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1770,722,219 - 70,854,437 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01774,551,031 - 74,683,236 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01768,594,018 - 68,726,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,971,915 - 71,105,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,971,915 - 71,105,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01772,669,688 - 72,800,895 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,486,998 - 78,566,741 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11778,497,951 - 78,520,090 (-)NCBI
Celera1766,745,895 - 66,876,546 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
Prkcq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542123,070,955 - 23,175,699 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542123,072,607 - 23,151,591 (-)NCBIChiLan1.0ChiLan1.0
PRKCQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2818,971,178 - 19,127,387 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11018,976,501 - 19,132,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0106,458,138 - 6,610,781 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1106,440,316 - 6,528,828 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl106,440,316 - 6,593,900 (-)Ensemblpanpan1.1panPan2
PRKCQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,319,123 - 29,505,338 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,318,870 - 29,505,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha226,357,031 - 26,536,629 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0229,699,579 - 29,881,298 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl229,699,661 - 29,881,826 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1226,803,522 - 26,983,171 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0227,646,081 - 27,819,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0228,365,332 - 28,538,905 (+)NCBIUU_Cfam_GSD_1.0
Prkcq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934431,883,098 - 32,000,850 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364848,048,132 - 8,167,636 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364848,048,239 - 8,166,058 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1064,458,180 - 64,600,339 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11064,442,588 - 64,596,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21070,558,968 - 70,659,135 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.196,532,438 - 6,675,708 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl96,532,319 - 6,621,487 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605111,850,149 - 11,993,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000021864   ⟹   ENSHGLP00000021654
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247751,419,509 - 1,502,064 (-)Ensembl
RefSeq Acc Id: XM_004854531   ⟹   XP_004854588
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247751,420,657 - 1,543,805 (-)NCBI
RefSeq Acc Id: XM_021266320   ⟹   XP_021121979
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247751,420,657 - 1,501,629 (-)NCBI
RefSeq Acc Id: XR_002398231
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247751,419,596 - 1,543,805 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004854588 (Get FASTA)   NCBI Sequence Viewer  
  XP_021121979 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021654
  ENSHGLP00100011778
GenBank Protein JAO01921 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004854588   ⟸   XM_004854531
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JK15 (UniProtKB/TrEMBL),   G5BP89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021121979   ⟸   XM_021266320
- Peptide Label: isoform X2
- UniProtKB: G5BP89 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000021654   ⟸   ENSHGLT00000021864


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015477 Ensembl, ENTREZGENE
  ENSHGLG00100008747 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000021864 ENTREZGENE
  ENSHGLT00100011915 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  nPKC_theta UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kin_PKC_delta UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser_Thr_kinase_AGC UniProtKB/TrEMBL
KEGG Report hgl:101724103 UniProtKB/TrEMBL
NCBI Gene Prkcq ENTREZGENE
PANTHER PROTEIN KINASE C THETA TYPE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  PKC_C2 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF PKC_delta UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A0P6JK15 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TM30_HETGA UniProtKB/TrEMBL
  G5BP89 ENTREZGENE, UniProtKB/TrEMBL