| 727782 | Prkag2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits AMP binding; AMP-activated protein kinase activity; protein kinase binding; INVOLVED IN regulation of catalytic activity; glycogen metabolic process (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kin ase (AMPK) signaling pathway; hypertrophic cardiomyopathy pathway; insulin signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; amitrole | 4 | 10744695 | 10985939 | Rat | 251 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1346463 | PRKAG2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015] | 7 | 151556127 | 151877115 | Human | 1342 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1549995 | Prkag2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | Predicted to enable adenyl ribonucleotide binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to contribute to AMP-activated protein kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; regu lation of carbon utilization; and regulation of primary metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart and pericardium; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 25067733 | 25311576 | Mouse | 307 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8761351 | Prkag2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits ADP binding (ortholog); AMP binding (ortholog); AMP-activated protein kinase activity (ortholog); INVOLVED IN glycogen metabolic process (ortholog); intracellular signal transduction (ortholog); regulation of catalytic activity (ortholog); PARTICIPATES IN adenosine mo nophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog) | NW_004955491 | 5852534 | 6048820 | Chinchilla | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11980936 | PRKAG2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits AMP binding (ortholog); AMP-activated protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of catalytic activity (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog) | 7 | 143143556 | 143463492 | Bonobo | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12160905 | PRKAG2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits AMP binding (ortholog); AMP-activated protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of catalytic activity (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog); INTERACTS WITH bisphenol A | 16 | 15521304 | 15786237 | Dog | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12686164 | Prkag2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits AMP binding (ortholog); AMP-activated protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of catalytic activity (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog) | NW_004936527 | 6907723 | 7168222 | Squirrel | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18558576 | PRKAG2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits AMP binding (ortholog); AMP-activated protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of catalytic activity (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog) | | | | Green Monkey | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13882531 | PRKAG2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits AMP binding (ortholog); AMP-activated protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of catalytic activity (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog) | | | | Pig | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626016762 | Prkag2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits ADP binding (ortholog); AMP binding (ortholog); AMP-activated protein kinase activity (ortholog); INVOLVED IN glycogen metabolic process (ortholog); intracellular signal transduction (ortholog); regulation of catalytic activity (ortholog); PARTICIPATES IN adenosine mo nophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog) | | | | Black Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908606 | Prkag2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | ENCODES a protein that exhibits ADP binding (ortholog); AMP binding (ortholog); AMP-activated protein kinase activity (ortholog); INVOLVED IN glycogen metabolic process (ortholog); intracellular signal transduction (ortholog); regulation of catalytic activity (ortholog); PARTICIPATES IN adenosine mo nophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog) | | | | Naked Mole-Rat | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242918 | prkag2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155242917 | prkag2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258862 | prkag2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6770814 | PRKAG2-AS1 | PRKAG2 antisense RNA 1 | INTERACTS WITH 17beta-estradiol; cadmium dichloride; carbamazepine | 7 | 151877042 | 151879223 | Human | 17 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16557588 | PRKAG2-AS2 | PRKAG2 antisense RNA 2 | | 7 | 151806338 | 151810820 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1609269 | Prkag2os1 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit, opposite strand 1 | INTERACTS WITH bis(2-ethylhexyl) phthalate; bisphenol F | 5 | 25107567 | 25111847 | Mouse | 5 | symbol , PhenoGen | gene, ncrna, PREDICTED [RefSeq] |
| 15556182 | Prkag2os2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit, opposite strand 2 | | | | | Mouse | | symbol , PhenoGen | gene, lncrna |