| 1306666 | Ppp2r5d | protein phosphatase 2, regulatory subunit B', delta | ENCODES a protein that exhibits protein phosphatase activator activity (ortholog); protein phosphatase regulator activity (ortholog); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation; PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; mRNA decay pathway ; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,6-dinitrotoluene; aconitine; bisphenol A | 9 | 21767963 | 21797997 | Rat | 101 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315410 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] | 6 | 42984570 | 43012342 | Human | 227 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315411 | Ppp2r5d | protein phosphatase 2, regulatory subunit B', delta | Enables protein phosphatase activator activity. Predicted to be involved in meiotic sister chromatid cohesion; negative regulation of peptidyl-threonine phosphorylation; and protein dephosphorylation. Predicted to act upstream of or within several processes, including positive regulation of neuron p rojection development; positive regulation of neurotrophin TRK receptor signaling pathway; and regulation of primary metabolic process. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to human PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 46993917 | 47015952 | Mouse | 122 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8789582 | Ppp2r5d | protein phosphatase 2 regulatory subunit B'delta | ENCODES a protein that exhibits protein phosphatase activator activity (ortholog); protein phosphatase regulator activity (ortholog); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; ASSOCIA TED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | NW_004955437 | 8968517 | 8987680 | Chinchilla | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11950729 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | ENCODES a protein that exhibits protein phosphatase activator activity (inferred); protein phosphatase regulator activity (inferred); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; ASSOCIA TED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | 6 | 42576759 | 42604609 | Bonobo | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12097013 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | ENCODES a protein that exhibits protein phosphatase activator activity (inferred); protein phosphatase regulator activity (inferred); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; ASSOCIA TED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | 12 | 11519194 | 11540658 | Dog | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12652579 | Ppp2r5d | protein phosphatase 2 regulatory subunit B'delta | ENCODES a protein that exhibits protein phosphatase activator activity (inferred); protein phosphatase regulator activity (inferred); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; ASSOCIA TED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936476 | 16922204 | 16945400 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13944124 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | ENCODES a protein that exhibits protein phosphatase activator activity (inferred); protein phosphatase regulator activity (inferred); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; ASSOCIA TED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 43 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18916435 | Ppp2r5d | protein phosphatase 2 regulatory subunit B'delta | ENCODES a protein that exhibits protein phosphatase activator activity (inferred); protein phosphatase regulator activity (inferred); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; ASSOCIA TED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626118664 | Ppp2r5d | protein phosphatase 2 regulatory subunit B'delta | ENCODES a protein that exhibits protein phosphatase activator activity (ortholog); protein phosphatase regulator activity (ortholog); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; ASSOCIA TED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18441041 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | ENCODES a protein that exhibits protein phosphatase activator activity (inferred); protein phosphatase regulator activity (inferred); INVOLVED IN negative regulation of peptidyl-threonine phosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; interleukin-2 signaling pathway; ASSOCIA TED WITH autosomal dominant intellectual developmental disorder 35 (ortholog); brain disease (ortholog); epilepsy (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |