| 1307093 | Ppef2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); Hsp90 protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); negative regulation of apoptotic signaling pathway (ortholog); negativ e regulation of MAPK cascade (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 3,3',4,4',5-pentachlorobiphenyl; cadmium dichloride | 14 | 16081706 | 16115903 | Rat | 56 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1316080 | PPEF2 | protein phosphatase with EF-hand domain 2 | This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expres sed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008] | 4 | 75859867 | 75902452 | Human | 51 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316081 | Ppef2 | protein phosphatase, EF hand calcium-binding domain 2 | Predicted to enable heat shock protein binding activity; mitogen-activated protein kinase kinase kinase binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and negative regulation of peptidyl-threonine phosphorylation. Predicted to be active in cytosol and nucleus. Orthologous to human PPEF2 (protein phosphatase with EF-hand domain 2). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 92374109 | 92404759 | Mouse | 55 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8981356 | Ppef2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); Hsp90 protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); negative regulation of apoptotic signaling pathway (ortholog); negativ e regulation of MAPK cascade (ortholog) | NW_004955474 | 1758988 | 1770427 | Chinchilla | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12007839 | PPEF2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits calcium ion binding (inferred); Hsp70 protein binding (inferred); Hsp90 protein binding (inferred); INVOLVED IN cellular response to hydrogen peroxide (inferred); detection of stimulus involved in sensory perception (inferred); negative regulation of apoptotic signali ng pathway (inferred) | 4 | 48308761 | 48345861 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12052990 | PPEF2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits calcium ion binding (inferred); Hsp70 protein binding (inferred); Hsp90 protein binding (inferred); INVOLVED IN cellular response to hydrogen peroxide (inferred); detection of stimulus involved in sensory perception (inferred); negative regulation of apoptotic signali ng pathway (inferred) | 32 | 443495 | 467929 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12590347 | Ppef2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits calcium ion binding (inferred); Hsp70 protein binding (inferred); Hsp90 protein binding (inferred); INVOLVED IN cellular response to hydrogen peroxide (inferred); detection of stimulus involved in sensory perception (inferred); negative regulation of apoptotic signali ng pathway (inferred) | NW_004936598 | 65009 | 102349 | Squirrel | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284566853 | ppef2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18659239 | PPEF2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits calcium ion binding (inferred); Hsp70 protein binding (inferred); Hsp90 protein binding (inferred); INVOLVED IN cellular response to hydrogen peroxide (inferred); detection of stimulus involved in sensory perception (inferred); negative regulation of apoptotic signali ng pathway (inferred) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625843484 | Ppef2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); Hsp90 protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); negative regulation of apoptotic signaling pathway (ortholog); negativ e regulation of MAPK cascade (ortholog) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926248 | Ppef2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); protein serine/threonine kinase inhibitor activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); negative regulation of apoptotic signalin g pathway (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14073404 | PPEF2 | protein phosphatase with EF-hand domain 2 | ENCODES a protein that exhibits calcium ion binding (inferred); Hsp70 protein binding (inferred); Hsp90 protein binding (inferred); INVOLVED IN cellular response to hydrogen peroxide (inferred); detection of stimulus involved in sensory perception (inferred); negative regulation of apoptotic signali ng pathway (inferred) | | | | Pig | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284567031 | ppef2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 38652132 | PPEF2-AS1 | PPEF2 antisense RNA1 | | 4 | 75878377 | 75888464 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, MODEL [RefSeq] |
| 16561214 | AC018659.2 | protein phosphatase, EF-hand calcium binding domain 2 (PPEF2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
