| 628893 | Plpp2 | phospholipid phosphatase 2 | ENCODES a protein that exhibits ceramide-1-phosphate phosphatase activity (ortholog); phosphatidate phosphatase activity (ortholog); sphingosine-1-phosphate phosphatase activity (ortholog); INVOLVED IN regulation of cell cycle G1/S phase transition; ceramide metabolic process (ortholog); phospholipi d dephosphorylation (ortholog); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN caveola (ortholog); early endosome (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether | 7 | 10826534 | 10834628 | Rat | 153 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734254 | PLPP2 | phospholipid phosphatase 2 | The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is simil ar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | 19 | 281043 | 291403 | Human | 141 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1550889 | Plpp2 | phospholipid phosphatase 2 | The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain an d heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] | 10 | 79362258 | 79369621 | Mouse | 164 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8866111 | Plpp2 | phospholipid phosphatase 2 | ENCODES a protein that exhibits ceramide-1-phosphate phosphatase activity (ortholog); phosphatidate phosphatase activity (ortholog); sphingosine-1-phosphate phosphatase activity (ortholog); INVOLVED IN ceramide metabolic process (ortholog); phospholipid dephosphorylation (ortholog); phospholipid met abolic process (ortholog); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN caveola (ortholog); early endosome (ortholog); endoplasmic reticulum (ortholog) | NW_004955495 | 7307079 | 7310898 | Chinchilla | 21 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935306 | Plpp2 | phospholipid phosphatase 2 | ENCODES a protein that exhibits ceramide-1-phosphate phosphatase activity (ortholog); sphingosine-1-phosphate phosphatase activity (ortholog); INVOLVED IN ceramide metabolic process (ortholog); regulation of cell cycle G1/S phase transition (ortholog); sphingosine metabolic process (ortholog); PARTI CIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN caveola (ortholog); early endosome (ortholog); endoplasmic reticulum (ortholog) | | | | Naked Mole-Rat | 29 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13934219 | PLPP2 | phospholipid phosphatase 2 | ENCODES a protein that exhibits ceramide-1-phosphate phosphatase activity (inferred); hydrolase activity (inferred); phosphatidate phosphatase activity (inferred); INVOLVED IN regulation of cell cycle G1/S phase transition (ortholog); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN caveola (inferred); early endosome (inferred); early endosome membrane (inferred) | | | | Pig | 34 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |