This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transc
ription start sites may result in use of alternate in-frame translation start codons that generate alternate isoforms that are targeted to the mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov 2017]
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammato
ry processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]
ENCODES a protein that exhibits antioxidant activity (ortholog); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to reactive oxygen species (ortholog); hydrogen peroxide catabolic process (or
tholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH alopecia areata (ortholog); brucellosis (ortholog); Chronic Hepatitis C (ortholog); FOUND IN mitochondrion; peroxisome; cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3-bis(4-hydroxyphenyl)propionitrile