| 1353016 | PIK3R6 | phosphoinositide-3-kinase regulatory subunit 6 | Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regu latory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] | 17 | 8802722 | 8867677 | Human | 72 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1560850 | Pik3r6 | phosphoinositide-3-kinase, regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (ortholog); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); positive regulation of angiogenesis (ortholog); positive regulatio n of MAP kinase activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (ortholog); phosphatidylinositol 3-kinase complex, class IB (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; asiaticoside; bisphenol A | 10 | 53702821 | 53754113 | Rat | 70 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1618254 | Pik3r6 | phosphoinositide-3-kinase regulatory subunit 5 | Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regu latory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] | 11 | 68393845 | 68443524 | Mouse | 73 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9009728 | Pik3r6 | phosphoinositide-3-kinase regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (ortholog); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); positive regulation of angiogenesis (ortholog); positive regulatio n of MAP kinase activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (ortholog); phosphatidylinositol 3-kinase complex, class IB (ortholog) | NW_004955467 | 8104242 | 8157637 | Chinchilla | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11852172 | PIK3R6 | phosphoinositide-3-kinase regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (inferred); INVOLVED IN positive regulation of MAP kinase activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin recept or bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (inferred); phosphatidylinositol 3-kinase complex (inferred); phosphatidylinositol 3-kinase complex, class IB (inferred) | 17 | 42782422 | 42851692 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12410655 | PIK3R6 | phosphoinositide-3-kinase regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (inferred); INVOLVED IN positive regulation of MAP kinase activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin recept or bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (inferred); phosphatidylinositol 3-kinase complex, class IB (inferred) | 5 | 33472240 | 33528369 | Dog | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12609753 | Pik3r6 | phosphoinositide-3-kinase regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (inferred); INVOLVED IN positive regulation of MAP kinase activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin recept or bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (inferred); phosphatidylinositol 3-kinase complex (inferred); phosphatidylinositol 3-kinase complex, class IB (inferred) | NW_004936595 | 1953372 | 1983765 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18415978 | PIK3R6 | phosphoinositide-3-kinase regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (inferred); INVOLVED IN positive regulation of MAP kinase activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin recept or bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (inferred); phosphatidylinositol 3-kinase complex (inferred); phosphatidylinositol 3-kinase complex, class IB (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904226 | Pik3r6 | phosphoinositide-3-kinase regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (ortholog); INVOLVED IN positive regulation of angiogenesis (ortholog); positive regulation of MAP kinase activity (ortholog); positive regulation of T cell differentiation (ortholog); PARTICIPATES IN eicosanoi d signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (ortholog) | | | | Naked Mole-Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238976 | pik3r6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625947763 | Pik3r6 | phosphoinositide-3-kinase regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (ortholog); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); positive regulation of angiogenesis (ortholog); positive regulatio n of MAP kinase activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (ortholog); phosphatidylinositol 3-kinase complex, class IB (ortholog) | | | | Black Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13982566 | PIK3R6 | phosphoinositide-3-kinase regulatory subunit 6 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (inferred); INVOLVED IN positive regulation of MAP kinase activity (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin recept or bidirectional signaling axis; insulin signaling pathway; FOUND IN membrane (inferred); phosphatidylinositol 3-kinase complex, class IB (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238900 | pik3r6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935692 | pik3r6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596936110 | pik3r6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935329 | pik3r6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596936145 | pik3r6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244296 | pik3r6.S | | | | | | African Clawed Frog | | symbol | gene, null |