| 11098 | Phka2 | phosphorylase kinase alpha 2 | Predicted to enable calmodulin binding activity. Predicted to be involved in glycogen metabolic process. Predicted to be located in plasma membrane. Predicted to be part of phosphorylase kinase complex. Is expressed in several structures, including adipose tissue; cardiovascular system; exocrine gla nd; female reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease IXa. Orthologous to human PHKA2 (phosphorylase kinase regulatory subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2025] | X | 159284900 | 159384772 | Mouse | 98 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1344785 | PHKA2 | phosphorylase kinase regulatory subunit alpha 2 | Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined.[provided by RefSeq, Feb 2010] | X | 18892298 | 18984114 | Human | 246 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1596945 | Phka2 | phosphorylase kinase regulatory subunit alpha 2 | ENCODES a protein that exhibits calmodulin binding (inferred); INVOLVED IN protein phosphorylation; PARTICIPATES IN glycogen degradation pathway; calcium/calcium-mediated signaling pathway; insulin signaling pathway; ASSOCIATED WITH glycogen storage disease IXA; genetic disease (ortholog); glycogen storage disease (ortholog); FOUND IN phosphorylase kinase complex; INTERACTS WITH bisphenol A; genistein; methoxychlor | X | 37979629 | 38102656 | Rat | 96 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, INFERRED [RefSeq] |
| 8814875 | Phka2 | phosphorylase kinase regulatory subunit alpha 2 | INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN glycogen degradation pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease (ortholog); glycogen storage disease IXA (ortholog); FOUND IN phosphorylase kinase complex (ortholog) | NW_004955586 | 482353 | 549512 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11715948 | PHKA2 | phosphorylase kinase regulatory subunit alpha 2 | ENCODES a protein that exhibits calmodulin binding (inferred); phosphorylase kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN glycogen degradation pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease (ortholog); glycogen storage dis ease IXA (ortholog); FOUND IN phosphorylase kinase complex (ortholog) | X | 11513747 | 11605382 | Bonobo | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12258196 | PHKA2 | phosphorylase kinase regulatory subunit alpha 2 | ENCODES a protein that exhibits calmodulin binding (inferred); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN glycogen degradation pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease (ortholog); glycogen storage disease IXA (ortholog); FOUND IN phosphorylas e kinase complex (ortholog) | X | 14911511 | 14989923 | Dog | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12698151 | Phka2 | phosphorylase kinase regulatory subunit alpha 2 | ENCODES a protein that exhibits calmodulin binding (inferred); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN glycogen degradation pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease (ortholog); glycogen storage disease IXA (ortholog); FOUND IN phosphorylas e kinase complex (ortholog) | NW_004936844 | 478773 | 548565 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405861612 | phka2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626064719 | Phka2 | phosphorylase kinase regulatory subunit alpha 2 | INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN glycogen degradation pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease (ortholog); glycogen storage disease IXA (ortholog); FOUND IN phosphorylase kinase complex (ortholog) | | | | Black Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912691 | Phka2 | phosphorylase kinase regulatory subunit alpha 2 | ENCODES a protein that exhibits calmodulin binding (inferred); kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN glycogen degradation pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease (ortholog); glycogen storage disease IXA (orth olog); FOUND IN phosphorylase kinase complex (ortholog) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18547552 | PHKA2 | phosphorylase kinase regulatory subunit alpha 2 | ENCODES a protein that exhibits calmodulin binding (inferred); phosphorylase kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN glycogen degradation pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease (ortholog); glycogen storage dis ease IXA (ortholog); FOUND IN phosphorylase kinase complex (ortholog) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13943391 | PHKA2 | phosphorylase kinase regulatory subunit alpha 2 | ENCODES a protein that exhibits calmodulin binding (inferred); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN glycogen degradation pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease (ortholog); glycogen storage disease IXA (ortholog); FOUND IN phosphorylas e kinase complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405860147 | phka2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405862987 | phka2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405859602 | phka2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405861611 | phka2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862161 | phka2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857297 | phka2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862989 | phka2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863097 | phka2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859603 | phka2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863673 | phka2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860146 | phka2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6767134 | PHKA2-AS1 | PHKA2 antisense RNA 1 | INTERACTS WITH benzo[a]pyrene; sodium arsenite | X | 18890296 | 18894975 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16571831 | AL732509.1 | novel transcript, antisense to ADGRG2and PHKA2 | | X | 18987587 | 19057133 | Human | | name | gene, ncrna, MODEL [RefSeq] |
| 626172758 | phka2l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
