| 1303187 | Phactr1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits protein phosphatase 1 binding; actin binding (ortholog); INVOLVED IN cellular response to mechanical stimulus; positive regulation of gene expression; regulation of modification of postsynaptic structure; ASSOCIATED WITH myocardial infarction; Acute Coronary Syndrome (ortholog); ARTERIAL DISSECTION (ortholog); FOUND IN cytoplasm; glutamatergic synapse; nucleus; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,4-dinitrotoluene; 6-propyl-2-thiouracil | 17 | 21769006 | 22246227 | Rat | 189 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1353173 | PHACTR1 | phosphatase and actin regulator 1 | The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are as sociated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] | 6 | 12716767 | 13287837 | Human | 235 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1615702 | Phactr1 | phosphatase and actin regulator 1 | Enables actin binding activity. Involved in nervous system development; regulation of neuron migration; and stress fiber assembly. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system and neural retina. Human ortholog(s) of this gene implicated in arte ry disease (multiple) and brain disease (multiple). Orthologous to human PHACTR1 (phosphatase and actin regulator 1). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 42833909 | 43292002 | Mouse | 180 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8947055 | Phactr1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits actin binding (ortholog); protein phosphatase 1 binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actomyosin structure organization (ortholog); cell motility (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); ARTERIAL DISSECTION (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | NW_004955465 | 1395418 | 1915820 | Chinchilla | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11677248 | PHACTR1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); positive regulation of gene expression (ortholog); regulation of modification of postsynaptic structure (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (orth olog); ARTERIAL DISSECTION (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | 6 | 12560862 | 13136126 | Bonobo | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12271673 | PHACTR1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); positive regulation of gene expression (ortholog); regulation of modification of postsynaptic structure (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (orth olog); ARTERIAL DISSECTION (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | 35 | 12233152 | 12745031 | Dog | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12584722 | Phactr1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); positive regulation of gene expression (ortholog); regulation of modification of postsynaptic structure (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (orth olog); ARTERIAL DISSECTION (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | NW_004936534 | 42354 | 323735 | Squirrel | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915392 | Phactr1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); INVOLVED IN actomyosin structure organization (ortholog); cellular response to mechanical stimulus (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); ARTERIAL DISSECTION (or tholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14093821 | PHACTR1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); positive regulation of gene expression (ortholog); regulation of modification of postsynaptic structure (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (orth olog); ARTERIAL DISSECTION (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | | | | Pig | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18395727 | PHACTR1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); positive regulation of gene expression (ortholog); regulation of modification of postsynaptic structure (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (orth olog); ARTERIAL DISSECTION (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | | | | Green Monkey | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626075978 | Phactr1 | phosphatase and actin regulator 1 | ENCODES a protein that exhibits actin binding (ortholog); protein phosphatase 1 binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actomyosin structure organization (ortholog); cell motility (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); ARTERIAL DISSECTION (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234623 | phactr1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155234624 | phactr1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248333 | phactr1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16552177 | AL008729.1 | novel transcript, antisense to PHACTR1 | | 6 | 13273094 | 13295586 | Human | | name | gene, ncrna, VALIDATED [RefSeq] |