| 11075 | Pepd | peptidase D | Enables peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 34611832 | 34744131 | Mouse | 235 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1354493 | PEPD | peptidase D | This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mu tations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] | 19 | 33386950 | 33521791 | Human | 257 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1594571 | Pepd | peptidase D | ENCODES a protein that exhibits peptidase activity (ortholog); proline dipeptidase activity (ortholog); INVOLVED IN negative regulation of programmed cell death (ortholog); proteolysis (ortholog); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disea se (ortholog); INTERACTS WITH 2,4-dinitrotoluene; acetamide; bis(2-ethylhexyl) phthalate | 1 | 96673624 | 96818197 | Rat | 164 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9062659 | Pepd | peptidase D | ENCODES a protein that exhibits peptidase activity (ortholog); proline dipeptidase activity (ortholog); INVOLVED IN negative regulation of programmed cell death (ortholog); proteolysis (ortholog); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disea se (ortholog) | NW_004955468 | 3147871 | 3277294 | Chinchilla | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11926292 | PEPD | peptidase D | ENCODES a protein that exhibits dipeptidase activity (inferred); hydrolase activity (inferred); manganese ion binding (inferred); INVOLVED IN collagen catabolic process (inferred); negative regulation of programmed cell death (inferred); proteolysis (inferred); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disease (ortholog) | 19 | 30309243 | 30450279 | Bonobo | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12219417 | PEPD | peptidase D | ENCODES a protein that exhibits dipeptidase activity (inferred); hydrolase activity (inferred); manganese ion binding (inferred); INVOLVED IN collagen catabolic process (inferred); negative regulation of programmed cell death (inferred); proteolysis (inferred); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disease (ortholog) | 1 | 118662560 | 118773193 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12719140 | Pepd | peptidase D | ENCODES a protein that exhibits dipeptidase activity (inferred); hydrolase activity (inferred); manganese ion binding (inferred); INVOLVED IN collagen catabolic process (inferred); negative regulation of programmed cell death (inferred); proteolysis (inferred); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disease (ortholog) | NW_004936570 | 2315981 | 2431878 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921590 | Pepd | peptidase D | ENCODES a protein that exhibits dipeptidase activity (inferred); hydrolase activity (inferred); manganese ion binding (inferred); INVOLVED IN collagen catabolic process (inferred); negative regulation of programmed cell death (inferred); proteolysis (inferred); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disease (ortholog) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18510192 | PEPD | peptidase D | ENCODES a protein that exhibits dipeptidase activity (inferred); hydrolase activity (inferred); manganese ion binding (inferred); INVOLVED IN collagen catabolic process (inferred); negative regulation of programmed cell death (inferred); proteolysis (inferred); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disease (ortholog) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14261356 | PEPD | peptidase D | ENCODES a protein that exhibits dipeptidase activity (inferred); hydrolase activity (inferred); manganese ion binding (inferred); INVOLVED IN collagen catabolic process (inferred); negative regulation of programmed cell death (inferred); proteolysis (inferred); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disease (ortholog) | | | | Pig | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243573 | pepd | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626111973 | Pepd | peptidase D | ENCODES a protein that exhibits peptidase activity (ortholog); proline dipeptidase activity (ortholog); INVOLVED IN negative regulation of programmed cell death (ortholog); proteolysis (ortholog); ASSOCIATED WITH chronic ulcer of skin (ortholog); disease by infectious agent (ortholog); genetic disea se (ortholog) | | | | Black Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245838 | pepd.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250104 | pepd.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16556489 | AC105021.1 | peptidase D (PEPD) pseudogene | | 17 | 55560907 | 55561609 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
