| 1322359 | PEG3 | paternally expressed 3 | In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exo ns unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009] | 19 | 56810082 | 56840726 | Human | 124 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322360 | Peg3 | paternally expressed 3 | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of tran scription by RNA polymerase II. Located in autophagosome and nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Orthologous to human PEG3 (paternally expressed 3). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 6706891 | 6733443 | Mouse | 136 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2323590 | Peg3 | paternally expressed 3 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 76130965 | 76157774 | Rat | 123 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9049961 | Peg3 | paternally expressed 3 | INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (ortholog); nucleus (ortholog) | NW_004955567 | 85913 | 96236 | Chinchilla | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12158115 | PEG3 | paternally expressed 3 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (ortholog); INTERACTS WITH bisphenol A | 1 | 101091161 | 101123552 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12700371 | Peg3 | paternally expressed 3 | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymera se II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (inferred); cytoplasm (inferred); nucleus (inferred) | NW_004936882 | 577424 | 607691 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18906490 | Peg3 | paternally expressed 3 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (ortholog) | | | | Naked Mole-Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18617421 | PEG3 | paternally expressed 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polyme rase II (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626104766 | Peg3 | paternally expressed 3 | INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (ortholog); nucleus (ortholog) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14134324 | PEG3 | paternally expressed 3 | ENCODES a protein that exhibits DNA binding (inferred); double-stranded DNA binding (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of gene exp ression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (inferred); cytoplasm (inferred); nucleus (inferred); INTERACTS WITH resveratrol | | | | Pig | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 2301272 | PEG3-AS1 | PEG3 antisense RNA 1 | This gene is located in the paternally expressed gene 3 (PEG3) imprinted region on chromosome 19. The corresponding transcript in mouse is imprinted and regulates expression of the mouse Peg3 gene. [provided by RefSeq, Sep 2 016] | 19 | 56812480 | 56813793 | Human | 8 | symbol , GTEx , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 626419682 | Peg3em1Soar | paternally expressed 3; endonuclease induced mutant 1, Soar | Crispr/Cas9 genome editing of the Peg3 gene | | | | Rat | | symbol , description | gene, allele |
| 1551247 | Aggf1 | angiogenic factor with G patch and FHA domains 1 | Predicted to enable identical protein binding activity and nucleic acid binding activity. Predicted to be involved in cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; egg cylinder; genitourinary system; primitive streak; and sensory organ. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 95487191 | 95511865 | Mouse | 104 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 11899247 | LOC100987733 | paternally-expressed gene 3 protein | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polyme rase II (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Parasitic Liver Diseases (ortholog); FOUND IN autophagosome (inferred); cytoplasm (inferred); nucleus (inferred) | 19 | 53830193 | 53860760 | Bonobo | 20 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 5553053 | Peg3os | Peg3 opposite strand | INTERACTS WITH 1,2-dichloroethane; 4,4'-sulfonyldiphenol; bisphenol A | 7 | 6709759 | 6710623 | Mouse | 8 | symbol , PhenoGen , name , old_gene_symbol | gene, ncrna, PROVISIONAL [RefSeq] |
| 1319059 | MELK | maternal embryonic leucine zipper kinase | Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 36572895 | 36677682 | Human | 195 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1349311 | ZIM2 | zinc finger imprinted 2 | In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010] | 19 | 56774547 | 56840726 | Human | 23 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 9586533 | ZIM2-AS1 | ZIM2 antisense RNA 1 | INTERACTS WITH aristolochic acid A | 19 | 56765322 | 56799646 | Human | 1 | ensembl_full_name | gene, ncrna, VALIDATED [RefSeq] |