| 621793 | Pde11a | phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ortholog); cGMP binding (ortholog); INVOLVED IN negative regulation of cAMP/PKA signal transduction; negative regulation of receptor guanylyl cyclase signaling pathway; PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon; cytosol (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; all-trans-retinoic acid; ammonium chloride | 3 | 81320822 | 81704397 | Rat | 103 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737612 | PDE11A | phosphodiesterase 11A | The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP a nd cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 2 | 177623244 | 178108339 | Human | 195 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1616522 | Pde11a | phosphodiesterase 11A | Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Predicted to be involved in cAMP-mediated signaling; negative regulation of cAMP-mediated signaling; and negative regulation of cGMP-mediated signaling. Predicted to be located in perikaryon. Is express ed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 2. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 75816152 | 76169501 | Mouse | 117 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8847982 | Pde11a | phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ortholog); cGMP binding (ortholog); INVOLVED IN negative regulation of cAMP/PKA signal transduction (ortholog); negative regulation of receptor guanylyl cyclase signaling pathway (ortholog); PARTICIPA TES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon (ortholog) | NW_004955403 | 18804789 | 19180612 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12244580 | PDE11A | phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (inferred); 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-GMP phosphodiesterase activity (inferred); INVOLVED IN negative regulation of cAMP/PKA signal transduction (ortholog); n egative regulation of receptor guanylyl cyclase signaling pathway (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon (ortholog) | 36 | 21347171 | 21701976 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12548366 | Pde11a | phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (inferred); 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-GMP phosphodiesterase activity (inferred); INVOLVED IN negative regulation of cAMP/PKA signal transduction (ortholog); n egative regulation of receptor guanylyl cyclase signaling pathway (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon (ortholog) | NW_004936509 | 6943758 | 7322192 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14030700 | PDE11A | phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (inferred); 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-GMP phosphodiesterase activity (inferred); INVOLVED IN negative regulation of cAMP/PKA signal transduction (ortholog); n egative regulation of receptor guanylyl cyclase signaling pathway (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon (ortholog) | | | | Pig | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920978 | Pde11a | phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ortholog); cGMP binding (ortholog); INVOLVED IN negative regulation of cAMP/PKA signal transduction (ortholog); negative regulation of receptor guanylyl cyclase signaling pathway (ortholog); PARTICIPA TES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon (ortholog) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18420297 | PDE11A | phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (inferred); 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-GMP phosphodiesterase activity (inferred); INVOLVED IN negative regulation of cAMP/PKA signal transduction (ortholog); n egative regulation of receptor guanylyl cyclase signaling pathway (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon (ortholog) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237671 | pde11a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625887292 | Pde11a | phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ortholog); cGMP binding (ortholog); INVOLVED IN negative regulation of cAMP/PKA signal transduction (ortholog); negative regulation of receptor guanylyl cyclase signaling pathway (ortholog); PARTICIPA TES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246236 | pde11a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251025 | pde11a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14974841 | PDE11A-AS1 | PDE11A antisense RNA 1 | INTERACTS WITH perfluorooctane-1-sulfonic acid | 2 | 177673322 | 177723289 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 597538573 | IFT70A-AS1 | IFT70A antisense RNA 1 | | 2 | 177603060 | 177619238 | Human | | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 12000625 | LOC100982736 | dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (inferred); 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-GMP phosphodiesterase activity (inferred); INVOLVED IN negative regulation of cAMP/PKA signal transduction (ortholog); n egative regulation of receptor guanylyl cyclase signaling pathway (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome 16 (ortholog); primary pigmented nodular adrenocortical disease 2 (ortholog); schizophrenia (ortholog); FOUND IN perikaryon (ortholog) | 2B | 64903170 | 65332922 | Bonobo | 23 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16556603 | AC011998.2 | novel transcript, sense intronic to PDE11A | | | | | Human | | name | gene, lncrna |
| 728347 | Pde11a_v1 | phosphodiesterase 11A, variant 1 | INVOLVED IN negative regulation of cAMP/PKA signal transduction; negative regulation of receptor guanylyl cyclase signaling pathway | | | | Rat | 2 | symbol , description , old_gene_symbol | gene, splice |
| 728342 | Pde11a_v2 | phosphodiesterase 11A, variant 2 | INVOLVED IN negative regulation of cAMP/PKA signal transduction; negative regulation of receptor guanylyl cyclase signaling pathway | | | | Rat | 2 | symbol , description , old_gene_symbol | gene, splice |
| 728339 | Pde11a_v3 | phosphodiesterase 11A, variant 3 | ENCODES an splice that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN negative regulation of cAMP/PKA signal transduction; negative regulation of receptor guanylyl cyclase signaling pathway; FOUND IN cytosol (inferred) | | | | Rat | 19 | symbol , description , old_gene_symbol | gene, splice |