| 1309565 | Pbk | PDZ binding kinase | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH h epatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol | 15 | 44198506 | 44209572 | Rat | 247 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319973 | Pbk | PDZ binding kinase | Enables protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to UV; negative regulation of protein metabolic process; and negative regulation of stress-activated MAPK cascade. Predicted to be located in nucleus. Is expressed in several s tructures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PBK (PDZ binding kinase). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 66043337 | 66055271 | Mouse | 269 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1351038 | PBK | PDZ binding kinase | This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] | 8 | 27809624 | 27837817 | Human | 258 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8791056 | Pbk | PDZ binding kinase | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH h epatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (ortholog) | NW_004955403 | 50332167 | 50353147 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11763864 | PBK | PDZ binding kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (inferred) | 8 | 27084789 | 27112986 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12378410 | PBK | PDZ binding kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (ortholog) | 25 | 29751805 | 29781806 | Dog | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12446952 | Pbk | PDZ binding kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (inferred) | NW_004936675 | 704001 | 722769 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13949976 | PBK | PDZ binding kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH deoxynivalenol; resveratrol | | | | Pig | 24 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18936791 | Pbk | PDZ binding kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (ortholog) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251662 | pbk | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18361061 | PBK | PDZ binding kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626136363 | Pbk | PDZ binding kinase | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to UV (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH h epatocellular carcinoma (ortholog); polycystic ovary syndrome (ortholog); FOUND IN nucleus (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245536 | pbk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1589858 | Pbk-ps1 | PDZ binding kinase, pseudogene 1 | | 2 | 148572276 | 148573434 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 626419692 | Pbkem1Dfult | PDZ binding kinase; endonuclease induced mutant 1, Dfult | CRISPR-Cas9 technology was used to generate a PBK KO rat. Cas9 editing of exon 4 in the rat PBK gene resulted in the insertion of a single âTâ resulting in a frame shift and premature termination of the PBK ght:700;'>PBK protein. | | | | Rat | | symbol , description | gene, allele |
| 1350657 | RSL1D1 | ribosomal L1 domain containing 1 | Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in regulation of apoptotic process and regulation of cellular senescence. Acts upstream of or within regulation of protein localization. Located in several cellular components, including cilium; cytosol; and nucleolus. [ provided by Alliance of Genome Resources, Jul 2025] | 16 | 11833850 | 11851542 | Human | 135 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1558081 | Rsl1d1 | ribosomal L1 domain containing 1 | Predicted to enable mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to be involved in regulation of apoptotic process and regulation of cellular senescence. Predicted to act upstream of or within regulation of protein localization. Located in nucleolus. Is expressed in sever al structures, including eye; genitourinary system; liver; lung; and spleen. Orthologous to human RSL1D1 (ribosomal L1 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 11010901 | 11021156 | Mouse | 142 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |