| 1320571 | PAOX | polyamine oxidase | Enables polyamine oxidase activity. Involved in polyamine metabolic process and positive regulation of spermidine biosynthetic process. Predicted to be located in cytosol and peroxisomal matrix. Predicted to be active in cytoplasm. Implicated in lung non-small cell carcinoma. [provided by Alliance o f Genome Resources, Jul 2025] | 10 | 133379262 | 133391694 | Human | 97 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1320572 | Paox | polyamine oxidase (exo-N4-amino) | Enables polyamine oxidase activity. Acts upstream of or within polyamine catabolic process. Predicted to be located in peroxisomal matrix. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human PAOX (polyamine oxidase). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 139693182 | 139714249 | Mouse | 112 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561125 | Paox | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity; INVOLVED IN polyamine catabolic process; spermidine catabolic process; spermine catabolic process; PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); s troke (ortholog); FOUND IN peroxisomal matrix; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 1 | 204349326 | 204358140 | Rat | 94 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8983754 | Paox | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); positive regulation of spermidine biosynthetic process (ortholog); putrescine biosynthetic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autis m spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); stroke (ortholog); FOUND IN peroxisomal matrix (ortholog) | NW_004955477 | 11028488 | 11038556 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12589241 | Paox | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); spermidine catabolic process (ortholog); spermine catabolic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); stroke (ortholog); FOUND IN peroxisomal matrix (ortholog) | NW_004936486 | 19503631 | 19511918 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14133950 | PAOX | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); spermidine catabolic process (ortholog); spermine catabolic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); stroke (ortholog); FOUND IN peroxisomal matrix (ortholog) | | | | Pig | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18780567 | PAOX | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); spermidine catabolic process (ortholog); spermine catabolic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); stroke (ortholog); FOUND IN peroxisomal matrix (ortholog) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625961077 | Paox | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); positive regulation of spermidine biosynthetic process (ortholog); putrescine biosynthetic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autis m spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); stroke (ortholog); FOUND IN peroxisomal matrix (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12392167 | PAOX | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); spermidine catabolic process (ortholog); spermine catabolic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); stroke (ortholog); FOUND IN peroxisomal matrix (ortholog) | | | | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11893715 | PAOX | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); spermidine catabolic process (ortholog); spermine catabolic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); stroke (ortholog); FOUND IN peroxisomal matrix (ortholog) | | | | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928768 | Paox | polyamine oxidase | ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); positive regulation of spermidine biosynthetic process (ortholog); putrescine biosynthetic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autis m spectrum disorder (ortholog); lung non-small cell carcinoma (ortholog); stroke (ortholog); FOUND IN peroxisomal matrix (ortholog) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251698 | paox | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155250306 | paox.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284176447 | XB5760632 [provisional:paox] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 287767582 | XB5760632.L [provisional:paox] | | | | | | African Clawed Frog | | symbol | gene, null |
| 732685 | Acox1 | acyl-Coenzyme A oxidase 1, palmitoyl | This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in micr ovesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] | 11 | 116062714 | 116089605 | Mouse | 574 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |