Paox (polyamine oxidase) - Rat Genome Database

Name: Paox
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Paox (polyamine oxidase) Chinchilla lanigera

Analyze

Symbol:

Paox

Name:

polyamine oxidase

RGD ID:

8983754

Description:

ENCODES a protein that exhibits polyamine oxidase activity (ortholog); INVOLVED IN polyamine catabolic process (ortholog); positive regulation of spermidine biosynthetic process (ortholog); putrescine biosynthetic process (ortholog); PARTICIPATES IN polyamine metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); distal 10q deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN peroxisomal matrix (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

peroxisomal N(1)-acetyl-spermine/spermidine oxidase; polyamine oxidase (exo-N4-amino)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PAOX (polyamine oxidase)	NCBI	Ortholog
Mus musculus (house mouse):	Paox (polyamine oxidase (exo-N4-amino))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Paox (polyamine oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PAOX (polyamine oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PAOX (polyamine oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Paox (polyamine oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PAOX (polyamine oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PAOX (polyamine oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Paox (polyamine oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955477	11,028,488 - 11,038,556 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955477	11,028,488 - 11,038,556 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

distal 10q deletion syndrome (ISO)

genetic disease (ISO)

lung non-small cell carcinoma (ISO)

Stroke (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

polyamine catabolic process (ISO)

positive regulation of spermidine biosynthetic process (ISO)

putrescine biosynthetic process (ISO)

putrescine catabolic process (ISO)

spermidine catabolic process (ISO)

spermine catabolic process (ISO)

Cellular Component

peroxisomal matrix (ISO)

Molecular Function

polyamine oxidase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

polyamine metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Paox
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955477	11,028,488 - 11,038,556 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955477	11,028,488 - 11,038,556 (+)	NCBI	ChiLan1.0	ChiLan1.0

PAOX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	133,379,262 - 133,391,694 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	133,379,261 - 133,391,694 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	135,192,766 - 135,205,198 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	135,042,731 - 135,055,188 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	128,312,520 - 128,324,936 (-)	NCBI		Celera
Cytogenetic Map	10	q26.3	NCBI
HuRef	10	128,736,502 - 128,748,922 (+)	NCBI		HuRef
CHM1_1	10	135,474,601 - 135,487,056 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	134,334,280 - 134,346,667 (+)	NCBI		T2T-CHM13v2.0

Paox
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	139,693,182 - 139,714,249 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	139,695,712 - 139,717,137 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	140,115,735 - 140,134,334 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	140,115,799 - 140,137,224 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	147,311,584 - 147,320,233 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	139,977,005 - 139,985,654 (+)	NCBI		MGSCv36	mm8
Celera	7	139,923,748 - 139,932,506 (+)	NCBI		Celera
Cytogenetic Map	7	F4	NCBI
cM Map	7	85.14	NCBI

Paox
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	204,349,326 - 204,358,140 (+)	NCBI		GRCr8
mRatBN7.2	1	194,919,655 - 194,928,498 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	194,903,273 - 194,928,504 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	203,280,563 - 203,289,378 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	210,410,132 - 210,418,933 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	203,083,972 - 203,092,773 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	212,578,444 - 212,603,722 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	212,578,450 - 212,603,529 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	219,493,093 - 219,518,141 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	199,909,816 - 199,934,938 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	192,580,329 - 192,605,793 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

PAOX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	145,507,801 - 145,520,620 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	145,513,017 - 145,525,980 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	10	134,294,760 - 134,307,179 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	134,294,760 - 134,307,179 (+)	Ensembl	panpan1.1		panPan2

PAOX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	28	41,012,273 - 41,021,920 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	41,591,869 - 41,601,016 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	41,591,704 - 41,601,293 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	41,076,628 - 41,086,255 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	41,065,490 - 41,074,781 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	41,468,552 - 41,477,690 (+)	NCBI		UU_Cfam_GSD_1.0

Paox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	6,049,380 - 6,063,882 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	19,503,631 - 19,511,920 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	19,503,631 - 19,511,918 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAOX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	141,360,608 - 141,369,641 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	141,360,509 - 141,369,642 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PAOX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	53,228,320 - 53,238,362 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	53,228,396 - 53,240,508 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	41,366,263 - 41,376,289 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Paox
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	13,312,201 - 13,324,559 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	13,312,728 - 13,324,559 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005402069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01055714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01229659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000004593 ⟹ ENSCLAP00000004508

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955477	11,028,488 - 11,038,556 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000004594 ⟹ ENSCLAP00000004509

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955477	11,028,547 - 11,038,310 (+)	Ensembl

RefSeq Acc Id:

XM_005402069 ⟹ XP_005402126

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955477	11,028,488 - 11,038,556 (+)	NCBI

Sequence:

show sequence

AGACTCTCTCGGAGCAGGCTATGGCGTCAGGCGGCGGCGGTAGACAGACCCCAGGCAGCCCGCG
GGTGCTGGTGGTGGGCGGCGGCATCGCGGGGCTGGGCGCCGCGCAGAGGCTGTGCCATTACTCT
GCCCCCCCGCACCTGCGCGTCGTGGAGGCCACGGCCCGCGCCGGGGGCCGCATCCGCTCGGAGC
GTGGCTTCGGTGGTGTGGTGGAGGTGGGAGCACATTGGATCCATGGGCCTTCCCAGGGCAACCC
TGTCTTCCAGCTGGCTGCTGCGTTCGGGCTCCTGGGGGAGAAGGAGTTGTCGGAAGAGAACCAG
TTGGTGGATACAGGAGGCCATTTAGACCTGCCCTCCATGTGCTGTACCAGTTCCGGGACAAGGG
TTAGCCCTGAACTGGTGGCAGAGATGGCCAGTCTGTTTTATGGGCTGATAGACCAGACCCGAGA
GTTCCTGCATGTGGCTAAGACCCCAGTGCCCAGTGTCGGGGAGTACCTCAAGAAGGAGATTGGA
CAGCAGGTGGCCCACTGGACAGAGGACAAGGAGACCAAGAAGCTCAAGCTGGCCATCCTGAACA
ACTTCTTCAATATGGAGTGCTGCATAAGTGGCACCCATAGCATGGACCTGGTAGCTCTTGCACC
CTTCGGGGAGTACACTGTGCTGCCAGGGCTGGACTGCACCTTTTCTGGGGGCTACCAGGGACTC
ACAAACAACATAATGGCCTCCTTGCCAAAGGACGTGATGGTTTTTAACAAGCCTGTGAAGACTA
TTCACTGGAATGGGTCCTTCCAGGAGGCAGCGTTTCCCGGGGAGACCTTTCCTGTGTTGGTGGA
GTGCGATGATGGTGGCCGCTTCCCAGCCCATCACGTCATCATCACTGTGCCCTTAGGTTTTCTG
AAAGAACATCAGGACACCTTCTTTGAACCGCCGCTGCCTGCTGAGAAGGTGGAAGCAATCAGGA
AAATAGGCTTTGGGACCAACAACAAAGTCTTCCTAGAGTTTGAAGAACCCTTCTGGGAGCCAGA
CTGCCAGTTCATTCGGGTGGTGTGGGAGGACACGTCGCCACTGCAGGACACTACCTCTGGGCTG
CAGGACACCTGGTTTAAGAAGCTCATTGGGTTTTTGGTCCTACCTTTTTCCAAGTCTGTGCACG
TGCTCTGTGGATTCATTGCTGGGCTGGAGTCTGAGTTCATGGAGACACTGTCCGATGAAGAAGT
ACTTCAGTCTTTAACCCAAGTGCTCCGGAGAGTGACAGGAAACCCACAACTACCTGCACCCAAG
AGTGTGCTGAGGTCTTGCTGGCATAGCACCCCCTATACTCGGGGTTCCTACAGCTATGTGGCCG
TGGGCAGCACTGGAGATGACATGGACCTACTGGCCCAGCCCCTCCCTGCAGATGGCACTGGCCC
CCAGCTCCAGGTACTGTTTGCAGGGGAAGCCACTCATCGGACATTTTACTCCACAACGCACGGG
GCCCTGCTGTCTGGCTGGAGGGAGGCTGACCGCCTCATGGGTCTGTGGGACCTGAAGATGCAGC
AGTCCTGGCCCAGGCTCTGAGCTGGGCTCCCACTGGCTCTGCTCCTCCTGTATGAAAGGCTGGG
ATACTCCTCTTCTCTGACAGATAATTTTCAGTCTGACTTGAGATTTTGGGATTTCACTGATAAG
TCTGTTTTGGGTAACTGGGTCATCTCATTTCTCACATCTATCGCTGGAGTCTGGCTAGGACTGA
GGTTGGGCTGAGTGTGACAGGAATGGGATACTGCTGTTAATGGTGATGCTTTGCATATAAAGCA
GTTAACAACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005402126	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000004508
	ENSCLAP00000004508.1
	ENSCLAP00000004509.1

RefSeq Acc Id:

XP_005402126 ⟸ XM_005402069

- UniProtKB:

A0A8C2UQV8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASGGGGRQTPGSPRVLVVGGGIAGLGAAQRLCHYSAPPHLRVVEATARAGGRIRSERGFGGVV
EVGAHWIHGPSQGNPVFQLAAAFGLLGEKELSEENQLVDTGGHLDLPSMCCTSSGTRVSPELVA
EMASLFYGLIDQTREFLHVAKTPVPSVGEYLKKEIGQQVAHWTEDKETKKLKLAILNNFFNMEC
CISGTHSMDLVALAPFGEYTVLPGLDCTFSGGYQGLTNNIMASLPKDVMVFNKPVKTIHWNGSF
QEAAFPGETFPVLVECDDGGRFPAHHVIITVPLGFLKEHQDTFFEPPLPAEKVEAIRKIGFGTN
NKVFLEFEEPFWEPDCQFIRVVWEDTSPLQDTTSGLQDTWFKKLIGFLVLPFSKSVHVLCGFIA
GLESEFMETLSDEEVLQSLTQVLRRVTGNPQLPAPKSVLRSCWHSTPYTRGSYSYVAVGSTGDD
MDLLAQPLPADGTGPQLQVLFAGEATHRTFYSTTHGALLSGWREADRLMGLWDLKMQQSWPRL

hide sequence

RefSeq Acc Id:

ENSCLAP00000004509 ⟸ ENSCLAT00000004594

RefSeq Acc Id:

ENSCLAP00000004508 ⟸ ENSCLAT00000004593

Protein Domains

Amine oxidase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003209	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000004593	ENTREZGENE
	ENSCLAT00000004593.1	UniProtKB/TrEMBL
	ENSCLAT00000004594.1	UniProtKB/TrEMBL
Gene3D-CATH	3.50.50.60	UniProtKB/TrEMBL
	3.90.660.10	UniProtKB/TrEMBL
InterPro	Amino_oxidase	UniProtKB/TrEMBL
	FAD/NAD-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Paox	ENTREZGENE
PANTHER	FLAVIN MONOAMINE OXIDASE	UniProtKB/TrEMBL
	PEROXISOMAL N(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE	UniProtKB/TrEMBL
Pfam	Amino_oxidase	UniProtKB/TrEMBL
	NAD_binding_8	UniProtKB/TrEMBL
Superfamily-SCOP	FAD-linked reductases, C-terminal domain	UniProtKB/TrEMBL
	SSF51905	UniProtKB/TrEMBL
UniProt	A0A8C2UQV8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2US80_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Paox	polyamine oxidase		polyamine oxidase (exo-N4-amino)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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