| 1359338 | Nhej1 | nonhomologous end-joining factor 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA end binding (ortholog); DNA polymerase binding (ortholog); INVOLVED IN B cell differentiation (ortholog); double-strand break repair via nonhomologous end joining (ortholog); immunoglobulin V(D)J recombination (ortholog); PARTICIPATES IN no n-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); choroid disease (ortholog); genetic disease (ortholog); FOUND IN DNA-dependent protein kinase-DNA ligase 4 complex (ortholog); fibrillar center (ortholog); nonhomologous end joining complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | 9 | 83974995 | 84071161 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1602683 | NHEJ1 | non-homologous end joining factor 1 | Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008] | 2 | 219069357 | 219160815 | Human | 152 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1623125 | Nhej1 | non-homologous end joining factor 1 | Predicted to enable DNA end binding activity and DNA polymerase binding activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA liga se 4 complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in severe combined immunodeficiency 124. Orthologous to human NHEJ1 (non-homologous end joining factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 75006505 | 75101870 | Mouse | 173 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8903168 | Nhej1 | non-homologous end joining factor 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA end binding (ortholog); DNA polymerase binding (ortholog); INVOLVED IN B cell differentiation (ortholog); double-strand break repair via nonhomologous end joining (ortholog); immunoglobulin V(D)J recombination (ortholog); PARTICIPATES IN no n-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); choroid disease (ortholog); genetic disease (ortholog); FOUND IN DNA-dependent protein kinase-DNA ligase 4 complex (ortholog); fibrillar center (ortholog); nonhomologous end joining complex (ortholog) | NW_004955453 | 14278773 | 14362167 | Chinchilla | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12004974 | NHEJ1 | non-homologous end joining factor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA end binding (inferred); DNA polymerase binding (inferred); INVOLVED IN B cell differentiation (inferred); DNA damage response (inferred); DNA repair (inferred); PARTICIPATES IN non-homologous end joining pathway of double-strand break repai r; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); choroid disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | 2B | 106326596 | 106419928 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12356698 | NHEJ1 | non-homologous end joining factor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA end binding (inferred); DNA polymerase binding (inferred); INVOLVED IN B cell differentiation (inferred); DNA damage response (inferred); DNA repair (inferred); PARTICIPATES IN non-homologous end joining pathway of double-strand break repai r; ASSOCIATED WITH choroid disease; cerebrotendinous xanthomatosis (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | 37 | 25637214 | 25719241 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12618069 | Nhej1 | non-homologous end joining factor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA end binding (inferred); DNA polymerase binding (inferred); INVOLVED IN B cell differentiation (inferred); DNA damage response (inferred); DNA repair (inferred); PARTICIPATES IN non-homologous end joining pathway of double-strand break repai r; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); choroid disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | NW_004936569 | 1494783 | 1578587 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18758807 | NHEJ1 | non-homologous end joining factor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA end binding (inferred); DNA polymerase binding (inferred); INVOLVED IN B cell differentiation (inferred); DNA damage response (inferred); DNA repair (inferred); PARTICIPATES IN non-homologous end joining pathway of double-strand break repai r; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); choroid disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625839832 | Nhej1 | non-homologous end joining factor 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA end binding (ortholog); DNA polymerase binding (ortholog); INVOLVED IN B cell differentiation (ortholog); double-strand break repair via nonhomologous end joining (ortholog); immunoglobulin V(D)J recombination (ortholog); PARTICIPATES IN no n-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH choroid disease (ortholog); genetic disease (ortholog); Microphthalmia/Coloboma 13 (ortholog); FOUND IN DNA-dependent protein kinase-DNA ligase 4 complex (ortholog); fibrillar center (ortholog); nonhomologous end joining complex (ortholog) | | | | Black Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244868 | nhej1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13891641 | NHEJ1 | non-homologous end joining factor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA end binding (inferred); DNA polymerase binding (inferred); INVOLVED IN B cell differentiation (inferred); DNA damage response (inferred); DNA repair (inferred); PARTICIPATES IN non-homologous end joining pathway of double-strand break repai r; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); choroid disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | | | | Pig | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933984 | Nhej1 | non-homologous end joining factor 1 | ENCODES a protein that exhibits DNA polymerase binding (ortholog); INVOLVED IN B cell differentiation (ortholog); immunoglobulin V(D)J recombination (ortholog); response to ionizing radiation (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WIT H cerebrotendinous xanthomatosis (ortholog); choroid disease (ortholog); genetic disease (ortholog); FOUND IN DNA-dependent protein kinase-DNA ligase 4 complex (ortholog); fibrillar center (ortholog); nonhomologous end joining complex (ortholog) | | | | Naked Mole-Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244945 | nhej1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16569892 | AC068946.1 | novel protein, SLC23A3-NHEJ1 readthrough | | | | | Human | | name | gene, protein-coding |