| 1309142 | Nfat5 | nuclear factor of activated T-cells 5 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); DNA damage response (ortholog); positive regulation of canonical N F-kappaB signal transduction (ortholog); PARTICIPATES IN B cell receptor signaling pathway; T cell receptor signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 19 | 52108982 | 52196418 | Rat | 250 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319318 | NFAT5 | nuclear factor of activated T cells 5 | The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mamm alian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 16 | 69565966 | 69704654 | Human | 940 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1319319 | Nfat5 | nuclear factor of activated T cells 5 | Enables DNA binding activity. Acts upstream of or within positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; and regulation of calcineurin-NFAT signaling cascade. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human NFAT5 (nuclear factor of activated T cells 5). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 108020072 | 108106149 | Mouse | 293 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8886008 | Nfat5 | nuclear factor of activated T cells 5 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); DNA damage response (ortholog); positive regulation of canonical N F-kappaB signal transduction (ortholog); ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955484 | 7034799 | 7142883 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11847380 | NFAT5 | nuclear factor of activated T cells 5 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RNA polymerase II (ortholo g); regulation of calcineurin-NFAT signaling cascade (ortholog); ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytosol (inferred) | 16 | 49942461 | 50080519 | Bonobo | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12421937 | NFAT5 | nuclear factor of activated T cells 5 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RNA polymerase II (ortholo g); regulation of calcineurin-NFAT signaling cascade (ortholog); ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytosol (inferred) | 5 | 79995292 | 80115116 | Dog | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12497979 | Nfat5 | nuclear factor of activated T cells 5 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RNA polymerase II (ortholo g); regulation of calcineurin-NFAT signaling cascade (ortholog); ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936475 | 19658917 | 19758936 | Squirrel | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18746505 | NFAT5 | nuclear factor of activated T cells 5 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RNA polymerase II (ortholo g); regulation of calcineurin-NFAT signaling cascade (ortholog); ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910636 | Nfat5 | nuclear factor of activated T cells 5 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RNA polymerase II (ortholo g); regulation of calcineurin-NFAT signaling cascade (ortholog); ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Naked Mole-Rat | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13955889 | NFAT5 | nuclear factor of activated T cells 5 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RNA polymerase II (ortholo g); regulation of calcineurin-NFAT signaling cascade (ortholog); ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH dibromine | | | | Pig | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234693 | nfat5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626012099 | Nfat5 | nuclear factor of activated T cells 5 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); DNA damage response (ortholog); positive regulation of canonical N F-kappaB signal transduction (ortholog); ASSOCIATED WITH autoimmune disease of gastrointestinal tract (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252983 | nfat5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234692 | nfat5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16567094 | AC009032.1 | novel transcript, sense intronic to NFAT5 | | | | | Human | | name | gene, lncrna |
