| 1560774 | Mlxip | MLX interacting protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN nucleocytoplasmic transport (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 12 | 38789404 | 38853059 | Rat | 119 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1602332 | MLXIP | MLX interacting protein | This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014] | 12 | 122078756 | 122147344 | Human | 123 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1623020 | Mlxip | MLX interacting protein | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within nucleocytoplasmic transport. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; craniocervical region bone; rib; testis; and urinary system. Orthologous to human MLXIP (MLX interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 123532438 | 123595998 | Mouse | 122 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8804875 | Mlxip | MLX interacting protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN nucleocytoplasmic transport (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | NW_004955482 | 6410182 | 6456582 | Chinchilla | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11703961 | MLXIP | MLX interacting protein | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN nucleocytoplasmic transport (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm (ortholog) | 12 | 119679514 | 119747932 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12166951 | MLXIP | MLX interacting protein | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); protein dimerization activity (inferred); INVOLVED IN nucleocytoplasmic transport (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm ( ortholog) | 26 | 7188078 | 7247388 | Dog | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12607899 | Mlxip | MLX interacting protein | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN nucleocytoplasmic transport (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm (ortholog) | NW_004936558 | 2316938 | 2371172 | Squirrel | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13895940 | MLXIP | MLX interacting protein | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); protein dimerization activity (inferred); INVOLVED IN nucleocytoplasmic transport (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm ( ortholog); INTERACTS WITH aldehydo-D-glucose; D-glucose; glucose | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18611607 | MLXIP | MLX interacting protein | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN nucleocytoplasmic transport (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm (ortholog) | | | | Green Monkey | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914160 | Mlxip | MLX interacting protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN nucleocytoplasmic transport (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253254 | mlxip | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625863340 | Mlxip | MLX interacting protein | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN nucleocytoplasmic transport (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Coronary Disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242434 | mlxip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155237767 | mlxip.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 620400 | Mlxipl | MLX interacting protein-like | ENCODES a protein that exhibits DNA binding; DNA-binding transcription factor activity; protein kinase binding; INVOLVED IN cellular response to glucose stimulus; energy homeostasis; fatty acid homeostasis; PARTICIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH end stage renal disease; Hypertriglyceridemia; Insulin Resistance; FOUND IN cytosol; nucleus; chromatin (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 27178158 | 27213675 | Rat | 313 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1343873 | MLXIPL | MLX interacting protein like | This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis ge nes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] | 7 | 73593202 | 73647907 | Human | 414 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1621550 | Mlxipl | MLX interacting protein-like | Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to DNA binding activity. Involved in glucose me diated signaling pathway; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of primary metabolic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is active in nucleoplasm. Is expressed in several structures, including central nervous system; gut; liver; metanephros; and nose. Used to study irritable bowel syndrome. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 135118744 | 135168622 | Mouse | 336 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9017864 | Mlxipl | MLX interacting protein like | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); energy homeostasis (ortholog); fatty aci d homeostasis (ortholog); PARTICIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); end stage renal disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955456 | 14096530 | 14116687 | Chinchilla | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11956449 | MLXIPL | MLX interacting protein like | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); protein homodimerization activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); energy homeostasis (ortholog); fatty acid homeostasis (ortholog); PARTI CIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); end stage renal disease (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog) | | | | Bonobo | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12155128 | MLXIPL | MLX interacting protein like | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); protein homodimerization activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); energy homeostasis (ortholog); fatty acid homeostasis (ortholog); PARTI CIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); end stage renal disease (ortholog); FOUND IN cytosol (ortholog) | 6 | 6617398 | 6652201 | Dog | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12502789 | Mlxipl | MLX interacting protein like | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); protein homodimerization activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); energy homeostasis (ortholog); fatty acid homeostasis (ortholog); PARTI CIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); end stage renal disease (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog) | NW_004936543 | 2839105 | 2856997 | Squirrel | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14142043 | MLXIPL | MLX interacting protein like | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); protein homodimerization activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); energy homeostasis (ortholog); fatty acid homeostasis (ortholog); PARTI CIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); end stage renal disease (ortholog); FOUND IN cytosol (ortholog) | | | | Pig | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18771208 | MLXIPL | MLX interacting protein like | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); protein homodimerization activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); energy homeostasis (ortholog); fatty acid homeostasis (ortholog); PARTI CIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); end stage renal disease (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog) | | | | Green Monkey | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919676 | Mlxipl | MLX interacting protein like | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); energy homeostasis (ortholog); fatty aci d homeostasis (ortholog); PARTICIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); end stage renal disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867430 | MLXIPL | MLX interacting protein like | | | | | Green Monkey | | symbol | gene, protein-coding |
| 287814261 | mlxipl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626144176 | Mlxipl | MLX interacting protein like | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); energy homeostasis (ortholog); fatty aci d homeostasis (ortholog); PARTICIPATES IN glycolysis/gluconeogenesis pathway; ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); end stage renal disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287390807 | mlxipl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856482 | mlxipl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859399 | mlxipl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861118 | mlxipl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864802 | mlxipl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626178113 | mlxipl.S | | | | | | African Clawed Frog | | symbol | gene, null |