| 1303251 | Mkrn1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); protein polyubiquitination (ortholog); INTERACTS WITH 3,4-methylenedioxymethamphetamine; bisphenol A; fipronil | 4 | 69142710 | 69170211 | Rat | 79 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1347564 | MKRN1 | makorin ring finger protein 1 | This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thoug ht to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] | 7 | 140453033 | 140479569 | Human | 81 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551460 | Mkrn1 | makorin, ring finger protein, 1 | Enables chromatin binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and spleen. Orthologous to several human genes including MKRN1 t:700;'>MKRN1 (makorin ring finger protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 39374738 | 39400480 | Mouse | 78 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8875416 | Mkrn1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); protein polyubiquitination (ortholog) | NW_004955494 | 2847783 | 2871095 | Chinchilla | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11720665 | MKRN1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog) | 7 | 132391357 | 132417395 | Bonobo | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12214612 | MKRN1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog) | 16 | 8508036 | 8530009 | Dog | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12490079 | Mkrn1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog) | NW_004936592 | 4533142 | 4539599 | Squirrel | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248497 | mkrn1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14145326 | MKRN1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog) | | | | Pig | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625875984 | Mkrn1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); protein polyubiquitination (ortholog) | | | | Black Rat | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14385308 | Mkrn1 | | | | | | Fly | | symbol | gene, null |
| 18654148 | MKRN1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog) | | | | Green Monkey | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914222 | Mkrn1 | makorin ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog) | | | | Naked Mole-Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626468685 | mkrn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861602 | mkrn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469234 | mkrn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862528 | mkrn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863357 | mkrn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863732 | mkrn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234034 | mkrn1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1615534 | Mkrn1-ps1 | makorin, ring finger protein 1, pseudogene 1 | | 5 | 88985658 | 88987258 | Mouse | | symbol , PhenoGen | gene, pseudo, VALIDATED [RefSeq] |
| 7676682 | Mkrn1-ps1 | makorin ring finger protein 1, pseudogene 1 | | 9 | 31168998 | 31170269 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16556058 | AC009969.1 | makorin, ring finger protein 1 (MKRN1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16556743 | AL512353.3 | makorin, ring finger protein, 1 (MKRN1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 38660642 | MKRN10P | makorin ring finger protein 10, pseudogene | | 9 | 96725821 | 96727467 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, PROVISIONAL [RefSeq] |
