| 1309386 | Mical1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits actin binding (ortholog); FAD binding (ortholog); monooxygenase activity (ortholog); INVOLVED IN actin filament depolymerization (ortholog); negative regulation of apoptotic process (ortholog); regulation of regulated secretory pathway (ortholog); ASSOCIATED WITH fami lial temporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endosome membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 20 | 46547983 | 46568487 | Rat | 194 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1604315 | MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in mult iple transcript variants. [provided by RefSeq, Aug 2015] | 6 | 109444062 | 109465968 | Human | 189 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1614217 | Mical1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | Enables several functions, including FAD binding activity; actin binding activity; and enzyme binding activity. Involved in several processes, including actin filament depolymerization; regulation of regulated secretory pathway; and sulfur oxidation. Located in hippocampal mossy fiber expansion. Ort hologous to human MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 41351693 | 41363026 | Mouse | 199 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8856337 | Mical1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits actin binding (ortholog); FAD binding (ortholog); monooxygenase activity (ortholog); INVOLVED IN actin filament depolymerization (ortholog); negative regulation of apoptotic process (ortholog); regulation of regulated secretory pathway (ortholog); ASSOCIATED WITH fami lial temporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endosome membrane (ortholog) | NW_004955411 | 34484536 | 34495154 | Chinchilla | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11864913 | MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits actin binding (inferred); F-actin monooxygenase activity (inferred); FAD binding (inferred); INVOLVED IN actin filament depolymerization (inferred); negative regulation of apoptotic process (inferred); regulation of regulated secretory pathway (inferred); ASSOCIATED W ITH familial temporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); cytosol (inferred) | 6 | 107247084 | 107269138 | Bonobo | 40 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12143356 | MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits actin binding (inferred); DNA binding (inferred); F-actin monooxygenase activity (inferred); INVOLVED IN actin filament depolymerization (inferred); DNA-templated transcription (inferred); negative regulation of apoptotic process (inferred); ASSOCIATED WITH familial t emporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); cytosol (inferred); INTERACTS WITH mocetinostat | 12 | 66350459 | 66358391 | Dog | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12713394 | Mical1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits actin binding (inferred); cytoskeletal protein binding (inferred); F-actin monooxygenase activity (inferred); INVOLVED IN actin filament depolymerization (inferred); negative regulation of apoptotic process (inferred); regulation of regulated secretory pathway (inferr ed); ASSOCIATED WITH familial temporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); cytosol (inferred) | NW_004936564 | 5568613 | 5579402 | Squirrel | 44 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626165122 | Mical1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits actin binding (ortholog); FAD binding (ortholog); monooxygenase activity (ortholog); INVOLVED IN actin filament depolymerization (ortholog); negative regulation of apoptotic process (ortholog); regulation of regulated secretory pathway (ortholog); ASSOCIATED WITH fami lial temporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endosome membrane (ortholog) | | | | Black Rat | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13896886 | MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits actin binding (inferred); cytoskeletal protein binding (inferred); F-actin monooxygenase activity (inferred); INVOLVED IN actin filament depolymerization (inferred); negative regulation of apoptotic process (inferred); regulation of regulated secretory pathway (inferr ed); ASSOCIATED WITH familial temporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 49 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18560842 | MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits actin binding (inferred); F-actin monooxygenase activity (inferred); FAD binding (inferred); INVOLVED IN actin filament depolymerization (inferred); negative regulation of apoptotic process (inferred); regulation of regulated secretory pathway (inferred); ASSOCIATED W ITH familial temporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); cytosol (inferred) | | | | Green Monkey | 40 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18908633 | Mical1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | ENCODES a protein that exhibits NAD(P)H oxidase H2O2-forming activity (ortholog); protein kinase binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); regulation of regulated secretory pathway (ortholog); ASSOCIATED WITH familial temporal lobe epilepsy 1 (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); hippocampal mossy fiber expansion (ortholog) | | | | Naked Mole-Rat | 33 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |