| 1309340 | Mapk11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding; MAP kinase activity; protein serine/threonine kinase activity (ortholog); INVOLVED IN protein phosphorylation; bone development (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN adenosine signaling pathway; eicosanoid signaling pa thway; FasL mediated signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 7 | 122098120 | 122105023 | Rat | 224 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319634 | MAPK11 | mitogen-activated protein kinase 11 | This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinfla mmatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] | 22 | 50263713 | 50270380 | Human | 228 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1319635 | Mapk11 | mitogen-activated protein kinase 11 | Enables MAP kinase activity. Involved in MAPK cascade; bone development; and osteoblast differentiation. Acts upstream of or within negative regulation of cardiac muscle cell proliferation. Is active in cytosol. Is expressed in genitourinary system; lung; nervous system; and sensory organ. Orthologo us to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 89026685 | 89033809 | Mouse | 262 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8977194 | Mapk11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN bone development (ortholog); cellular response to interleukin-1 (ortholog); cellular response to UV-B (ortholog); PARTICIPATES IN adenosine signali ng pathway; eicosanoid signaling pathway; FasL mediated signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN cytosol (ortholog) | NW_004955413 | 33287860 | 33293948 | Chinchilla | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11721507 | MAPK11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN negative regulation of cardiac muscle cell proliferation (ortholog); positive regulation of erythrocyte differentiation (ortholog); protein phosphorylation (ortholog); PARTICIPATES IN adenosine signal ing pathway; eicosanoid signaling pathway; FasL mediated signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN cytosol (inferred) | 22 | 30492664 | 30499456 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12403212 | MAPK11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN bone development (ortholog); cellular response to interleukin-1 (ortholog); cellular response to UV-B (ortholog); PARTICIPATES IN adenosine signaling pathway; eicosanoid signaling pathway; FasL mediat ed signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN cytosol (ortholog) | 10 | 16977133 | 16984764 | Dog | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12515569 | Mapk11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN negative regulation of cardiac muscle cell proliferation (ortholog); positive regulation of erythrocyte differentiation (ortholog); protein phosphorylation (ortholog); PARTICIPATES IN adenosine signal ing pathway; eicosanoid signaling pathway; FasL mediated signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN cytosol (inferred) | NW_004936629 | 542143 | 549861 | Squirrel | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14237241 | MAPK11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN negative regulation of cardiac muscle cell proliferation (ortholog); positive regulation of erythrocyte differentiation (ortholog); protein phosphorylation (ortholog); PARTICIPATES IN adenosine signal ing pathway; eicosanoid signaling pathway; FasL mediated signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN caveola (inferred); cytosol (inferred) | | | | Pig | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18464882 | MAPK11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN negative regulation of cardiac muscle cell proliferation (ortholog); positive regulation of erythrocyte differentiation (ortholog); protein phosphorylation (ortholog); PARTICIPATES IN adenosine signal ing pathway; eicosanoid signaling pathway; FasL mediated signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN cytosol (inferred) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932002 | Mapk11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN bone development (ortholog); cellular response to interleukin-1 (ortholog); cellular response to UV-B (ortholog); PARTICIPATES IN adenosine signaling pathway; eicosanoid signaling pathway; FasL mediat ed signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240198 | mapk11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625982521 | Mapk11 | mitogen-activated protein kinase 11 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN bone development (ortholog); cellular response to interleukin-1 (ortholog); cellular response to UV-B (ortholog); PARTICIPATES IN adenosine signali ng pathway; eicosanoid signaling pathway; FasL mediated signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240199 | mapk11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255788 | mapk11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1354160 | MAPKAPK5 | MAPK activated protein kinase 5 | The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11 ht:700;'>MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012] | 12 | 111842228 | 111902222 | Human | 149 | description | gene, protein-coding, REVIEWED [RefSeq] |