| 1304784 | Lmx1a | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN axon guidance (orthol og); central nervous system development (ortholog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acrylamide | 13 | 82367493 | 82511157 | Rat | 115 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1312426 | LMX1A | LIM homeobox transcription factor 1 alpha | This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] | 1 | 165201867 | 165356715 | Human | 118 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1312427 | Lmx1a | LIM homeobox transcription factor 1 alpha | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including midbrain dopaminergic neuron differentiation; olfactory behavior; and positive regul ation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of neuron differentiation; nervous system development; and regulation of cell growth. Predicted to be active in nucleus. Is expressed in several structures, including brain; ear; embryo ectoderm; notochord; and somite. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 7. Orthologous to human LMX1A (LIM homeobox transcription factor 1 alpha). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 167515864 | 167676310 | Mouse | 228 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8748736 | Lmx1a | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN axon guidance (orthol og); central nervous system development (ortholog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog) | NW_004955462 | 11328583 | 11484438 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11905772 | LMX1A | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); central nervous system development (ort holog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog); FOUND IN nucleus (inferred) | 1 | 140634117 | 140788567 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12322097 | LMX1A | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); central nervous system development (ort holog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog); FOUND IN nucleus (inferred) | 38 | 17958366 | 18111155 | Dog | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12670218 | Lmx1a | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); central nervous system development (ort holog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog); FOUND IN nucleus (inferred) | NW_004936481 | 19863487 | 19984299 | Squirrel | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626092518 | Lmx1a | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN axon guidance (orthol og); central nervous system development (ortholog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14115808 | LMX1A | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); central nervous system development (ort holog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14385383 | Lmx1a | | | | | | Fly | | symbol | gene, null |
| 18931656 | Lmx1a | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); central nervous system development (ort holog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239704 | lmx1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18640058 | LMX1A | LIM homeobox transcription factor 1 alpha | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); central nervous system development (ort holog); central nervous system neuron differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 7 (ortholog); Hearing Loss (ortholog); schizophrenia (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239703 | lmx1a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235747 | lmx1a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14700849 | LMX1A-AS1 | LMX1A antisense RNA 1 | | 1 | 165215955 | 165219044 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 14700853 | LMX1A-AS2 | LMX1A antisense RNA 2 | | 1 | 165204047 | 165212923 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, MODEL [RefSeq] |