| 62056 | Limk2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity; protein kinase activity (ortholog); INVOLVED IN protein phosphorylation; astral microtubule organization (ortholog); cornea development in camera-type eye (ortholog); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; F c gamma receptor mediated signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN centrosome (ortholog); cis-Golgi network (ortholog); cytoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 14 | 82384256 | 82509755 | Rat | 158 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 62348 | Limk2 | LIM domain kinase 2 | Enables protein kinase activity. Acts upstream of or within several processes, including cornea development in camera-type eye; protein phosphorylation; and spermatogenesis. Located in cis-Golgi network and nucleus. Is expressed in several structures, including alimentary system; central nervous sys tem; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 3293297 | 3359238 | Mouse | 173 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733238 | LIMK2 | LIM domain kinase 2 | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein i nteractions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 22 | 31212298 | 31280080 | Human | 147 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8774400 | Limk2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN astral microtubule organization (ortholog); cornea development in camera-type eye (ortholog); establishment of vesicle localization (ortholog); ASSOCIATED WITH Experim ental Liver Cirrhosis (ortholog); FOUND IN centrosome (ortholog); cis-Golgi network (ortholog); cytoplasm (ortholog) | NW_004955455 | 5406085 | 5473418 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12027375 | LIMK2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN cornea development in camera-type eye (ortholog); head development (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN centrosome (inferred); cis-Golgi network (inferred); cytoplasm (inferred) | 22 | 12235611 | 12304013 | Bonobo | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12161223 | LIMK2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN cornea development in camera-type eye (ortholog); head development (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN centrosome (inferred); cis-Golgi network (inferred); cytoplasm (inferred) | 26 | 24182595 | 24242429 | Dog | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12572054 | Limk2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN cornea development in camera-type eye (ortholog); head development (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN centrosome (inferred); cis-Golgi network (inferred); cytoplasm (inferred) | NW_004936755 | 374279 | 443255 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18395878 | LIMK2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN cornea development in camera-type eye (ortholog); head development (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN centrosome (inferred); cis-Golgi network (inferred); cytoplasm (inferred) | | | | Green Monkey | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236654 | limk2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18927135 | Limk2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN astral microtubule organization (ortholog); cornea development in camera-type eye (ortholog); establishment of vesicle localization (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FO UND IN cis-Golgi network (ortholog); cytosol (ortholog); mitotic spindle (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625998183 | Limk2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN astral microtubule organization (ortholog); cornea development in camera-type eye (ortholog); establishment of vesicle localization (ortholog); ASSOCIATED WITH Experim ental Liver Cirrhosis (ortholog); FOUND IN centrosome (ortholog); cis-Golgi network (ortholog); cytoplasm (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13855287 | LIMK2 | LIM domain kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN cornea development in camera-type eye (ortholog); head development (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN centrosome (inferred); cis-Golgi network (inferred); cytoplasm (inferred) | | | | Pig | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246796 | limk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155237411 | limk2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1583261 | Limk2-ps1 | LIM domain kinase 2, pseudogene 1 | | 7 | 65931325 | 65932422 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 14200767 | RNF185 | ring finger protein 185 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN defense response to virus (inferred); ERAD pathway (inferred); positive regulation of ERAD pathway (inferred); FOUND IN centrosome (inferred); cytoplasm (inferred); cytoskele ton (inferred) | | | | Pig | 58 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 25671526 | LIMK2P1 | LIMK2 pseudogene 1 | | X | 11704246 | 11705613 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 12283247 | RNF185 | ring finger protein 185 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN defense response to virus (ortholog); ERAD pathway (ortholog); positive regulation of ERAD pathway (ortholog); FOUND IN centrosome (inferred); cis-Golgi network (inferred); cytopl asm (inferred) | 26 | 24146172 | 24177747 | Dog | 66 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |