| 1344708 | LETMD1 | LETM1 domain containing 1 | This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011] | 12 | 51048220 | 51068958 | Human | 95 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552508 | Letmd1 | LETM1 domain containing 1 | Enables molecular adaptor activity. Involved in mitochondrion organization and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including non-canonical NF-kappaB signal transduction; nucleobase-containing compound biosynthetic process; and toll-like re ceptor 4 signaling pathway. Located in mitochondrial inner membrane. Is active in nucleus. Is expressed in several structures, including brain; cranial ganglion; dorsal root ganglion; and retina. Orthologous to human LETMD1 (LETM1 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 100360302 | 100377133 | Mouse | 119 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1596738 | Letmd1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN mitocho ndrial inner membrane (ortholog); mitochondrion (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 7 | 133461920 | 133476592 | Rat | 98 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8732434 | Letmd1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN mitocho ndrial inner membrane (ortholog); mitochondrion (ortholog); nucleus (ortholog) | NW_004955547 | 1574210 | 1586432 | Chinchilla | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12042664 | LETMD1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (inferred); ribosome binding (inferred); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred); nucleus (inferred) | 12 | 37685741 | 37705104 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12199580 | LETMD1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (inferred); ribosome binding (inferred); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred); nucleus (inferred) | 27 | 3761880 | 3770158 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12493401 | Letmd1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (inferred); ribosome binding (inferred); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred); nucleus (inferred) | NW_004936512 | 8684597 | 8694074 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929400 | Letmd1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN nucleus (ortholog) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625997760 | Letmd1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN mitocho ndrial inner membrane (ortholog); mitochondrion (ortholog); nucleus (ortholog) | | | | Black Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13982802 | LETMD1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (inferred); ribosome binding (inferred); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred); nucleus (inferred) | | | | Pig | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18677024 | LETMD1 | LETM1 domain containing 1 | ENCODES a protein that exhibits molecular adaptor activity (inferred); ribosome binding (inferred); INVOLVED IN ATP biosynthetic process (ortholog); calcium ion homeostasis (ortholog); gene expression (ortholog); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred); nucleus (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235146 | letmd1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155235145 | letmd1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242032 | letmd1.S | | | | | | African Clawed Frog | | symbol | gene, null |