| 621053 | Lamc2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (ortholog); INVOLVED IN positive regulation of cell migration (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN cell-extracellular matrix signaling pathway; Entamoebiasis pathway; small cell lung carcinoma pat hway; ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); genetic disease (ortholog); FOUND IN cell cortex; extracellular space; laminin-211 trimer; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 67835199 | 67894694 | Rat | 265 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315384 | LAMC2 | laminin subunit gamma 2 | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, co mposed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011] | 1 | 183186264 | 183258968 | Human | 410 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315385 | Lamc2 | laminin, gamma 2 | Enables heparin binding activity. Predicted to be involved in several processes, including axon guidance; positive regulation of cell migration; and positive regulation of cell population proliferation. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, incl uding alimentary system; basement membrane; central nervous system; genitourinary system; and skin. Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 152998502 | 153062193 | Mouse | 314 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8869879 | Lamc2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (ortholog); INVOLVED IN positive regulation of cell migration (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); genetic disease (ortholog); F OUND IN basement membrane (ortholog); cell cortex (ortholog); extracellular space (ortholog) | NW_004955406 | 22020330 | 22074271 | Chinchilla | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11917201 | LAMC2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (inferred); INVOLVED IN animal organ morphogenesis (inferred); axon guidance (inferred); cell adhesion (inferred); ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); genetic disease (ortholog); FOUND IN cell cortex (ort holog); extracellular space (ortholog); laminin-211 trimer (ortholog) | 1 | 158697084 | 158763209 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12266651 | LAMC2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (inferred); INVOLVED IN cell adhesion (inferred); positive regulation of cell migration (inferred); positive regulation of cell population proliferation (inferred); ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); gen etic disease (ortholog); FOUND IN cell cortex (ortholog); extracellular space (ortholog); laminin-211 trimer (ortholog); INTERACTS WITH bisphenol A | 7 | 16543541 | 16625304 | Dog | 38 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12698977 | Lamc2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (inferred); INVOLVED IN animal organ morphogenesis (inferred); axon guidance (inferred); cell adhesion (inferred); ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); genetic disease (ortholog); FOUND IN cell cortex (ort holog); extracellular space (ortholog); laminin-211 trimer (ortholog) | NW_004936481 | 6588797 | 6647167 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18482978 | LAMC2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (inferred); INVOLVED IN animal organ morphogenesis (inferred); axon guidance (inferred); cell adhesion (inferred); ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); genetic disease (ortholog); FOUND IN cell cortex (ort holog); extracellular space (ortholog); laminin-211 trimer (ortholog) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14231031 | LAMC2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (inferred); INVOLVED IN cell adhesion (inferred); positive regulation of cell migration (inferred); positive regulation of cell population proliferation (inferred); ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); gen etic disease (ortholog); FOUND IN cell cortex (ortholog); extracellular space (ortholog); laminin-211 trimer (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; deoxynivalenol | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907829 | Lamc2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (ortholog); INVOLVED IN positive regulation of cell migration (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); genetic disease (ortholog); F OUND IN cell cortex (ortholog); extracellular space (ortholog); laminin-211 trimer (ortholog) | | | | Naked Mole-Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625832993 | Lamc2 | laminin subunit gamma 2 | ENCODES a protein that exhibits heparin binding (ortholog); INVOLVED IN positive regulation of cell migration (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); Disease Progression (ortholog); genetic disease (ortholog); F OUND IN basement membrane (ortholog); cell cortex (ortholog); extracellular space (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250549 | lamc2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155236114 | lamc2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 13208472 | LAMC1-AS1 | LAMC1 antisense RNA 1 | INTERACTS WITH silicon dioxide; titanium dioxide | 1 | 183138402 | 183141270 | Human | 2 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
