| 1311339 | Kpna3 | karyopherin subunit alpha 3 | ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); INVOLVED IN protein import into nucleus (inferred); protein transport (inferred); ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WI TH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol | 15 | 39712375 | 39786127 | Rat | 114 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322742 | KPNA3 | karyopherin subunit alpha 3 | The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by a n active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009] | 13 | 49699320 | 49792682 | Human | 183 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322743 | Kpna3 | karyopherin subunit alpha 3 | Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytosol. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 61602635 | 61677396 | Mouse | 121 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8842784 | Kpna3 | karyopherin subunit alpha 3 | ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN NLS-dependent protein nuclear import complex (ortholog); nucleoplasm (ortholog) | NW_004955431 | 3147679 | 3176577 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11941906 | KPNA3 | karyopherin subunit alpha 3 | ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); INVOLVED IN protein import into nucleus (inferred); protein transport (inferred); ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN cytoplasm (inferred); NLS-dependent protein nuclear import complex (inferred); nuclear pore (inferred) | 13 | 30838320 | 30931608 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12142463 | KPNA3 | karyopherin subunit alpha 3 | ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); INVOLVED IN protein import into nucleus (inferred); protein transport (inferred); ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (i nferred); nucleus (inferred) | 22 | 2064733 | 2110524 | Dog | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12729809 | Kpna3 | karyopherin subunit alpha 3 | ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); INVOLVED IN protein import into nucleus (inferred); protein transport (inferred); ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (i nferred); nucleus (inferred) | NW_004936565 | 2738003 | 2775814 | Squirrel | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18411968 | KPNA3 | karyopherin subunit alpha 3 | ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); INVOLVED IN protein import into nucleus (inferred); protein transport (inferred); ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN cytoplasm (inferred); NLS-dependent protein nuclear import complex (inferred); nuclear pore (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904772 | Kpna3 | karyopherin subunit alpha 3 | ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); INVOLVED IN protein import into nucleus (inferred); protein transport (inferred); ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN NLS-dependent protein nuclear import complex (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14148898 | KPNA3 | karyopherin subunit alpha 3 | ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); INVOLVED IN protein import into nucleus (inferred); protein transport (inferred); ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (i nferred); nucleus (inferred) | | | | Pig | 37 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155252339 | kpna3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626049133 | Kpna3 | karyopherin subunit alpha 3 | ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 88 (ortholog); FOUND IN NLS-dependent protein nuclear import complex (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252338 | kpna3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257509 | kpna3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1583798 | Kpna3-ps1 | karyopherin subunit alpha 3, pseudogene 1 | | 1 | 95803047 | 95804626 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16567869 | AL136301.1 | novel transcript, antisense to KPNA3 | | | | | Human | | name | gene, lncrna |
