| 735064 | Kpna1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear localization sequence binding; nuclear import signal receptor activity (ortholog); INVOLVED IN NLS-bearing protein import into nucleus; postsynapse to nucleus signaling pathway (ortholog); regulation of apoptotic process (ortholog); PARTICIPATES IN phosphatidy linositol 3-kinase-Akt signaling pathway; influenza A pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN dendrite; nucleus; cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 11 | 78221165 | 78279778 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1347998 | KPNA1 | karyopherin subunit alpha 1 | The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by a n active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] | 3 | 122421902 | 122514939 | Human | 159 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552944 | Kpna1 | karyopherin subunit alpha 1 | Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including NLS-bearing protein import into nucleus; satellite cell activation involved in skeletal muscle regeneration; and skeletal muscle satellite cell proliferation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; gut; integumental system; and sensory organ. Orthologous to human KPNA1 (karyopherin subunit alpha 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 35803693 | 35859479 | Mouse | 156 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8829807 | Kpna1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear import signal receptor activity (ortholog); nuclear localization sequence binding (ortholog); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); postsynapse to nucleus signaling pathway (ortholog); regulation of apoptotic process (ortholog); PARTI CIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | NW_004955427 | 21705407 | 21764913 | Chinchilla | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12027019 | KPNA1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear localization sequence binding (ortholog); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); regulation of apoptotic process (ortholog); regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt si gnaling pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); nucleoplasm (ortholog) | 3 | 119513919 | 119604737 | Bonobo | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12344975 | KPNA1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); regulation of apoptotic process (ortholog); regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); nucleoplasm (ortholog) | 33 | 25561335 | 25631713 | Dog | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12456204 | Kpna1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear localization sequence binding (ortholog); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); regulation of apoptotic process (ortholog); regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt si gnaling pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); nucleoplasm (ortholog) | NW_004936536 | 8735159 | 8801385 | Squirrel | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14238803 | KPNA1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear localization sequence binding (ortholog); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); regulation of apoptotic process (ortholog); regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt si gnaling pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); nucleoplasm (ortholog) | | | | Pig | 52 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155250918 | kpna1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626143337 | Kpna1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear import signal receptor activity (ortholog); nuclear localization sequence binding (ortholog); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); postsynapse to nucleus signaling pathway (ortholog); regulation of apoptotic process (ortholog); PARTI CIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18667113 | KPNA1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear localization sequence binding (ortholog); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); regulation of apoptotic process (ortholog); regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt si gnaling pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); nucleoplasm (ortholog) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927570 | Kpna1 | karyopherin subunit alpha 1 | ENCODES a protein that exhibits nuclear localization sequence binding (ortholog); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); postsynapse to nucleus signaling pathway (ortholog); regulation of apoptotic process (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signali ng pathway; ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244080 | kpna1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246901 | kpna1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1589963 | Kpna1-ps2 | karyopherin subunit alpha 1, pseudogene 2 | | 14 | 119618 | 142759 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1598277 | Kpna1-ps3 | karyopherin subunit alpha 1, pseudogene 3 | | 6 | 71150751 | 71152586 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1590896 | Kpna1-ps4 | karyopherin subunit alpha 1, pseudogene 4 | | 18 | 33020816 | 33027846 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1563847 | Kpna1-ps5 | karyopherin subunit alpha 1, pseudogene 5 | INTERACTS WITH ammonium chloride | 2 | 127821159 | 127823201 | Rat | 1 | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1585995 | Kpna1-ps6 | karyopherin subunit alpha 1, pseudogene 6 | | 4 | 138374974 | 138376576 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1596721 | Kpna1-ps7 | karyopherin subunit alpha 1, pseudogene 7 | | X | 131950890 | 131952793 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1593493 | Kpna1-ps8 | karyopherin subunit alpha 1, pseudogene 8 | | 6 | 118247238 | 118248275 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1588628 | Kpna1-ps9 | karyopherin subunit alpha 1, pseudogene 9 | | 1 | 174222870 | 174224405 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1594342 | Kpna1-ps10 | karyopherin subunit alpha 1, pseudogene 10 | | X | 73948759 | 73952466 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16566534 | WDR5B-DT | WDR5B divergent transcript | INTERACTS WITH okadaic acid | 3 | 122416206 | 122443247 | Human | 1 | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |