KPNA1 (karyopherin subunit alpha 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: KPNA1 (karyopherin subunit alpha 1) Pan paniscus
Analyze
Symbol: KPNA1
Name: karyopherin subunit alpha 1
RGD ID: 12027019
Description: ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); nuclear localization sequence binding (inferred); INVOLVED IN NLS-bearing protein import into nucleus (ortholog); regulation of apoptotic process (ortholog); regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH alkaptonuria (ortholog); familial hypocalciuric hypercalcemia (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: importin subunit alpha-5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,370,934 - 120,459,639 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,374,860 - 120,464,419 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,513,919 - 119,604,737 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,418,157 - 126,510,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,421,700 - 126,510,325 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KPNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,370,934 - 120,459,639 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,374,860 - 120,464,419 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,513,919 - 119,604,737 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,418,157 - 126,510,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,421,700 - 126,510,325 (-)Ensemblpanpan1.1panPan2
KPNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,421,902 - 122,514,939 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,421,902 - 122,514,945 (-)EnsemblGRCh38hg38GRCh38
GRCh373122,140,749 - 122,233,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,623,438 - 123,716,474 (-)NCBINCBI36Build 36hg18NCBI36
Build 343123,627,216 - 123,716,335NCBI
Celera3120,550,374 - 120,643,600 (-)NCBICelera
Cytogenetic Map3q21.1NCBI
HuRef3119,513,915 - 119,606,857 (-)NCBIHuRef
CHM1_13122,104,233 - 122,197,287 (-)NCBICHM1_1
T2T-CHM13v2.03125,141,131 - 125,234,261 (-)NCBIT2T-CHM13v2.0
Kpna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,803,693 - 35,859,479 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1635,799,120 - 35,857,501 (+)EnsemblGRCm39 Ensembl
GRCm381635,983,288 - 36,037,136 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,978,750 - 36,037,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv371635,983,449 - 36,036,248 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361635,903,110 - 35,955,909 (+)NCBIMGSCv36mm8
Celera1636,463,542 - 36,516,772 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.43NCBI
Kpna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,221,165 - 78,279,778 (-)NCBIGRCr8
mRatBN7.21164,715,844 - 64,774,647 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,717,563 - 64,774,623 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,546,142 - 73,586,119 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,208,404 - 66,248,383 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,239,652 - 65,279,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,652,573 - 67,717,180 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,652,577 - 67,703,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,738,335 - 70,805,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,555,859 - 66,595,898 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,610,214 - 66,653,556 (-)NCBI
Celera1164,186,787 - 64,226,798 (-)NCBICelera
Cytogenetic Map11q22NCBI
Kpna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,705,412 - 21,764,913 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,705,407 - 21,764,913 (-)NCBIChiLan1.0ChiLan1.0
KPNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,561,335 - 25,631,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,566,419 - 25,631,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,585,686 - 25,656,082 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,796,537 - 25,867,021 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,782,759 - 25,867,039 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,593,501 - 25,663,791 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,636,870 - 25,707,309 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,194,435 - 26,265,045 (-)NCBIUU_Cfam_GSD_1.0
Kpna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602128,720,609 - 128,786,630 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365368,737,488 - 8,801,428 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365368,735,159 - 8,801,385 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,018,407 - 138,103,838 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,045,083 - 138,100,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213147,681,201 - 147,711,773 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KPNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,346,008 - 58,437,737 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,346,009 - 58,439,143 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041107,903,389 - 108,002,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624912772,420 - 822,580 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000053961   ⟹   ENSPPAP00000031097
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3126,421,700 - 126,510,325 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000053967   ⟹   ENSPPAP00000031103
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3126,453,542 - 126,491,673 (-)Ensembl
RefSeq Acc Id: XM_003825192   ⟹   XP_003825240
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22120,370,934 - 120,459,639 (-)NCBI
NHGRI_mPanPan13120,374,860 - 120,464,419 (-)NCBI
Mhudiblu_PPA_v03119,513,919 - 119,604,736 (-)NCBI
PanPan1.13126,418,157 - 126,510,325 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008950492   ⟹   XP_008948740
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22120,370,934 - 120,459,626 (-)NCBI
NHGRI_mPanPan13120,374,860 - 120,464,383 (-)NCBI
Mhudiblu_PPA_v03119,513,919 - 119,604,737 (-)NCBI
PanPan1.13126,421,700 - 126,510,276 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055110349   ⟹   XP_054966324
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22120,370,934 - 120,459,333 (-)NCBI
NHGRI_mPanPan13120,374,860 - 120,464,113 (-)NCBI
RefSeq Acc Id: XM_055110350   ⟹   XP_054966325
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22120,370,934 - 120,459,370 (-)NCBI
NHGRI_mPanPan13120,374,860 - 120,464,149 (-)NCBI
RefSeq Acc Id: XM_055110351   ⟹   XP_054966326
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22120,370,934 - 120,459,336 (-)NCBI
NHGRI_mPanPan13120,374,860 - 120,464,116 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003825240   ⟸   XM_003825192
- UniProtKB: A0A2R9BX67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008948740   ⟸   XM_008950492
- UniProtKB: A0A2R9BX67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000031097   ⟸   ENSPPAT00000053961
RefSeq Acc Id: ENSPPAP00000031103   ⟸   ENSPPAT00000053967
RefSeq Acc Id: XP_054966325   ⟸   XM_055110350
- UniProtKB: A0A2R9BX67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054966326   ⟸   XM_055110351
- UniProtKB: A0A2R9BX67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054966324   ⟸   XM_055110349
- UniProtKB: A0A2R9BX67 (UniProtKB/TrEMBL)
Protein Domains
IBB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038484 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053961.1 UniProtKB/TrEMBL
  ENSPPAT00000053967.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.690 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Importin-a_IBB UniProtKB/TrEMBL
  Importin-a_IBB_sf UniProtKB/TrEMBL
  Importin_alpha UniProtKB/TrEMBL
KEGG Report pps:100983357 UniProtKB/TrEMBL
NCBI Gene KPNA1 ENTREZGENE
PANTHER IMPORTIN ALPHA UniProtKB/TrEMBL
  IMPORTIN SUBUNIT ALPHA-5 UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
PIRSF Importin_alpha UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A2R9BRP8_PANPA UniProtKB/TrEMBL
  A0A2R9BX67 ENTREZGENE, UniProtKB/TrEMBL