| 3419 | Klk6 | kallikrein related-peptidase 6 | ENCODES a protein that exhibits peptidase activity; serine-type endopeptidase activity (ortholog); INVOLVED IN regulation of neuron projection development; positive regulation of G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH demyelination; ASSOCIATED WITH Spinal Cord Injur ies; Alzheimer's disease (ortholog); breast carcinoma (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); extracellular region (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil | 1 | 103415411 | 103422682 | Rat | 115 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733840 | Klk6 | kallikrein related-peptidase 6 | Predicted to enable serine-type endopeptidase activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway; protein maturation; and regulation of neuron projection development. Is active in cornified envelope. Is expressed in several structures, including brain. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (kallikrein related peptidase 6). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 43473967 | 43481219 | Mouse | 139 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736738 | KLK6 | kallikrein related peptidase 6 | This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically p rocessed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] | 19 | 50958631 | 50969591 | Human | 126 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9027040 | Klk6 | kallikrein related peptidase 6 | ENCODES a protein that exhibits peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN positive regulation of G protein-coupled receptor signaling pathway (ortholog); regulation of neuron projection development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortho log); breast carcinoma (ortholog); demyelinating disease (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); extracellular region (ortholog) | NW_004955558 | 1501806 | 1509461 | Chinchilla | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11748728 | KLK6 | kallikrein related peptidase 6 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN regulation of neuron projection development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); breast carcinoma (ortholog); demyelinating disease (ortholog); FOUND IN cornified envelope (inferred); cytoplasm (inferre d); extracellular region (inferred) | 19 | 47925017 | 47936314 | Bonobo | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12365935 | KLK6 | kallikrein related peptidase 6 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN positive regulation of G protein-coupled receptor signaling pathway (ortholog); regulation of neuron projection development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); breast carcinoma (ortholog); demyelinatin g disease (ortholog); FOUND IN cornified envelope (ortholog); nucleoplasm (ortholog); INTERACTS WITH digoxin; Doramectin; ivermectin | 1 | 105902147 | 105907585 | Dog | 41 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12661798 | Klk6 | kallikrein related peptidase 6 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN regulation of neuron projection development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); breast carcinoma (ortholog); demyelinating disease (ortholog); FOUND IN cornified envelope (inferred); cytoplasm (inferre d); extracellular region (inferred) | NW_004936889 | 621645 | 628454 | Squirrel | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14036242 | KLK6 | kallikrein related peptidase 6 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN regulation of neuron projection development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); breast carcinoma (ortholog); demyelinating disease (ortholog); FOUND IN cornified envelope (inferred); cytoplasm (inferre d); extracellular region (inferred) | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18700713 | KLK6 | kallikrein related peptidase 6 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN regulation of neuron projection development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); breast carcinoma (ortholog); demyelinating disease (ortholog); FOUND IN cornified envelope (inferred); cytoplasm (inferre d); extracellular region (inferred) | | | | Green Monkey | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626025504 | Klk6 | kallikrein related peptidase 6 | ENCODES a protein that exhibits peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN positive regulation of G protein-coupled receptor signaling pathway (ortholog); regulation of neuron projection development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortho log); breast carcinoma (ortholog); demyelinating disease (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); extracellular region (ortholog) | | | | Black Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 19259572 | KLK6 | kallikrein related peptidase 6 | | | | | Dog | | symbol | gene, protein-coding |
| 18901723 | Klk6 | kallikrein related peptidase 6 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN positive regulation of G protein-coupled receptor signaling pathway (ortholog); regulation of neuron projection development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); breast carcinoma (ortholog); demyelinatin g disease (ortholog); FOUND IN cornified envelope (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1313338 | Klk1 | kallikrein 1 | This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic clea vage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein are unable to generate significant levels of kinins in most tissues, develop cardiovascular abnormalities and exhibit hypercalciuria of renal origin. This gene is located in a cluster of several related kallikrein genes on chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, Feb 2016] | 7 | 43874784 | 43879046 | Mouse | 149 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1349866 | KLK1 | kallikrein 1 | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members l ocated in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008] | 19 | 50819146 | 50823787 | Human | 146 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1303220 | Klk1c6 | kallikrein 1-related peptidase C6 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); INTERACTS WITH 17beta-estradiol; furan; Muraglitazar | 1 | 103604150 | 103612366 | Rat | 18 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1305359 | Klk1c8 | kallikrein 1-related peptidase C8 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); INTERACTS WITH acrylamide; benomyl; bisphenol A | 1 | 103684293 | 103688155 | Rat | 18 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16565201 | AC011483.2 | novel transcript, antisense to KLK5 and KLK6 | | | | | Human | | name | gene, lncrna |
| 16564865 | AC011483.1 | novel transcript, antisense to KLK6, KLK7, KLK8 and KLK9 | | | | | Human | | name | gene, lncrna |
