| 1309490 | Klhl20 | kelch-like family member 20 | ENCODES a protein that exhibits type II interferon binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (ortholog); negative regulation of apoptotic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (orthol og); PARTICIPATES IN E-cadherin signaling pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride | 13 | 75896802 | 75941724 | Rat | 96 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1343100 | KLHL20 | kelch like family member 20 | The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present bo th throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008] | 1 | 173714981 | 173786692 | Human | 83 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550848 | Klhl20 | kelch-like 20 | Predicted to enable type II interferon binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Golgi to endosome transport; proteasome-mediated ubiquitin-depende nt protein catabolic process; and protein K33-linked ubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in PML body and trans-Golgi network. Is expressed in cranial ganglion; dorsal root ganglion; hindbrain; and thymus primordium. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 160915945 | 160959078 | Mouse | 107 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8817253 | Klhl20 | kelch like family member 20 | ENCODES a protein that exhibits type II interferon binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (ortholog); negative regulation of apoptotic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (orthol og); PARTICIPATES IN E-cadherin signaling pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955406 | 13891589 | 13938964 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11855565 | KLHL20 | kelch like family member 20 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (inferred); negative regulation of apoptotic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); PARTICIPATES IN E-cadherin signali ng pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN axon (inferred); Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred) | 1 | 149232858 | 149303357 | Bonobo | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12105606 | KLHL20 | kelch like family member 20 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (inferred); negative regulation of apoptotic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); PARTICIPATES IN E-cadherin signali ng pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred) | 7 | 25430490 | 25484245 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12467513 | Klhl20 | kelch like family member 20 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (inferred); negative regulation of apoptotic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); PARTICIPATES IN E-cadherin signali ng pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936481 | 14074169 | 14111634 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625936046 | Klhl20 | kelch like family member 20 | ENCODES a protein that exhibits type II interferon binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (ortholog); negative regulation of apoptotic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (orthol og); PARTICIPATES IN E-cadherin signaling pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18738365 | KLHL20 | kelch like family member 20 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (inferred); negative regulation of apoptotic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); PARTICIPATES IN E-cadherin signali ng pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN axon (inferred); Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242581 | klhl20 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13935102 | KLHL20 | kelch like family member 20 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (inferred); negative regulation of apoptotic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); PARTICIPATES IN E-cadherin signali ng pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926427 | Klhl20 | kelch like family member 20 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); PARTICIPATES IN E-cadherin signaling pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate canc er (ortholog); FOUND IN cytoplasm (ortholog); Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233102 | klhl20.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242580 | klhl20.S | | | | | | African Clawed Frog | | symbol | gene, null |