| 621445 | Klf4 | KLF transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; INVOLVED IN cellular response to endothelin; cellular response to hydrogen peroxide; cellular response to retinoic acid; A SSOCIATED WITH Carotid Artery Injuries; Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin; transcription regulator complex; cytoplasm (ortholog); INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 5 | 75074107 | 75079182 | Rat | 514 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1342656 | KLF4 | KLF transcription factor 4 | This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by medi ating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] | 9 | 107484852 | 107489769 | Human | 488 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553264 | Klf4 | Kruppel-like transcription factor 4 (gut) | Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity. Involved in several processes, including canonical Wnt signaling pathway; establishment of skin barrier; and fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of DNA-templated transcription; and regulation of blastocyst development. Located in cytoplasm; euchromatin; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (KLF transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 55527137 | 55536984 | Mouse | 609 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9034946 | Klf4 | KLF transcription factor 4 | ENCODES a protein that exhibits beta-catenin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cell differentiation (ortholog); cellular response to endoth elin (ortholog); ASSOCIATED WITH Carotid Artery Injuries (ortholog); Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); euchromatin (ortholog) | NW_004955419 | 19280311 | 19284097 | Chinchilla | 126 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11943453 | KLF4 | KLF transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell differentiation (ortholog); cellular response to endothelin (ortholog); cellular response to hydrogen peroxide (ortholog); ASSOCIATED WITH Carotid Artery Injuries (ortholog); Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); transcription regulator complex (ortholog) | 9 | 78634545 | 78639447 | Bonobo | 120 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12180477 | KLF4 | KLF transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell differentiation (ortholog); cellular response to endothelin (ortholog); cellular response to hydrogen peroxide (ortholog); ASSOCIATED WITH Carotid Artery Injuries (ortholog); Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin (ortholog); transcription regulator complex (ortholog) | 11 | 62881840 | 62886676 | Dog | 119 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12501592 | Klf4 | KLF transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell differentiation (ortholog); cellular response to endothelin (ortholog); cellular response to hydrogen peroxide (ortholog); ASSOCIATED WITH Carotid Artery Injuries (ortholog); Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); transcription regulator complex (ortholog) | NW_004936559 | 5105456 | 5109970 | Squirrel | 119 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13897826 | KLF4 | KLF transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell differentiation (ortholog); cellular response to endothelin (ortholog); cellular response to hydrogen peroxide (ortholog); ASSOCIATED WITH Carotid Artery Injuries (ortholog); Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin (ortholog); transcription regulator complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 120 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18537728 | KLF4 | KLF transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell differentiation (ortholog); cellular response to endothelin (ortholog); cellular response to hydrogen peroxide (ortholog); ASSOCIATED WITH Carotid Artery Injuries (ortholog); Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); transcription regulator complex (ortholog) | | | | Green Monkey | 119 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930192 | Klf4 | KLF transcription factor 4 | ENCODES a protein that exhibits beta-catenin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cell differentiation (ortholog); cellular response to endoth elin (ortholog); ASSOCIATED WITH Carotid Artery Injuries (ortholog); Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); euchromatin (ortholog) | | | | Naked Mole-Rat | 129 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248860 | klf4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625936537 | Klf4 | KLF transcription factor 4 | ENCODES a protein that exhibits beta-catenin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cell differentiation (ortholog); cellular response to endoth elin (ortholog); ASSOCIATED WITH Carotid Artery Injuries (ortholog); Congenital Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); euchromatin (ortholog) | | | | Black Rat | 126 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155260189 | klf4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245224 | klf4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1587479 | Klf4-ps1 | Kruppel like factor 4, pseudogene 1 | | 5 | 161204268 | 161258448 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1599569 | Klf4m1Mcwi | KLF transcription factor 4; mutation 1, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); V243I mutation is generated from the codon change GTC/ATC | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 1599559 | Klf4m2Mcwi | KLF transcription factor 4; mutation 2, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); I150N mutation is generated from the codon change ATC/AAC | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 1642179 | Klf4m3Mcwi | KLF transcription factor 4; mutation 3, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); H344L mutation is generated from the codon change CAT/CTT | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 8548455 | KLF4P1 | KLF4 pseudogene 1 | | 9 | 4803791 | 4805034 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 628703 | Baalc | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; bisphenol A | 7 | 71803640 | 71877608 | Rat | 66 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736795 | BAALC | BAALC binder of MAP3K1 and KLF4 | This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode di fferent proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 2008] | 8 | 103140725 | 103230305 | Human | 66 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 8834040 | Baalc | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | NW_004955417 | 27426764 | 27436620 | Chinchilla | 5 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11784209 | BAALC | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 8 | 99796292 | 99942112 | Bonobo | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12221537 | BAALC | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 13 | 4602688 | 4684138 | Dog | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12516352 | Baalc | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | NW_004936470 | 40506596 | 40590537 | Squirrel | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14287361 | BAALC | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane raft (inferred); INTERACTS WITH zearalenone | | | | Pig | 12 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18636601 | BAALC | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18935527 | Baalc | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 5 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625945376 | Baalc | BAALC binder of MAP3K1 and KLF4 | ASSOCIATED WITH acute myeloid leukemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 5 | name | gene, protein-coding, MODEL [RefSeq] |
| 733883 | Baalc | brain and acute leukemia, cytoplasmic | Located in sarcoplasm. Is expressed in several structures, including blood vessel wall; central nervous system; embryo mesenchyme; male reproductive gland or organ; and musculature. Orthologous to human BAALC (BAALC binder of MAP3K1 and KLF4). [provided by Allia nce of Genome Resources, Jul 2025] | 15 | 38739763 | 38814659 | Mouse | 72 | description | gene, protein-coding, VALIDATED [RefSeq] |