| 1348258 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] | 1 | 110210314 | 110284080 | Human | 119 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1589169 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated potassium channel activity; INVOLVED IN axon development; cerebral cortex development; corpus callosum development; ASSOCIATED WITH Hyperalgesia; sciatic neuropathy; status epilepticus; FOUND IN axon; calyx of Held; cell surface; INTERACTS WITH (+)-pilocarpine; (5Z,8Z,11Z,13E)-15-HETE; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 197747095 | 197788467 | Rat | 130 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1616662 | Kcnc4 | potassium voltage gated channel, Shaw-related subfamily, member 4 | Predicted to enable delayed rectifier potassium channel activity; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Acts upstream of or w ithin regulation of neurotransmitter secretion. Located in axon terminus and neuromuscular junction. Is expressed in central nervous system; olfactory epithelium; and peripheral nervous system ganglion. Orthologous to human KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 107345614 | 107367617 | Mouse | 125 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8975539 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activ ity (ortholog); INVOLVED IN axon development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | NW_004955435 | 13728272 | 13750420 | Chinchilla | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12018879 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 1 | 112860887 | 112884687 | Bonobo | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12056086 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 6 | 41743214 | 41764572 | Dog | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12439346 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | NW_004936704 | 1667387 | 1689337 | Squirrel | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18676144 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Green Monkey | 63 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155257440 | kcnc4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18904921 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14170346 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | | | | Pig | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626135712 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activ ity (ortholog); INVOLVED IN axon development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | | | | Black Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626182232 | kcnc4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865590 | kcnc4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858080 | kcnc4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865279 | kcnc4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359604 | kcnc4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856215 | kcnc4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359477 | kcnc4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6481439 | KCNC4-DT | KCNC4 divergent transcript | INTERACTS WITH propofol | 1 | 110208450 | 110209987 | Human | 1 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
