| 1309288 | Iyd | iodotyrosine deiodinase | ENCODES a protein that exhibits FMN binding (ortholog); iodotyrosine deiodinase activity (ortholog); INVOLVED IN thyroid hormone metabolic process (ortholog); tyrosine metabolic process (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormonogenesis 4 (ortholog); FOUND IN cytoplasmic vesicle membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol | 1 | 42410099 | 42425414 | Rat | 168 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319553 | Iyd | iodotyrosine deiodinase | Enables FMN binding activity and iodotyrosine deiodinase activity. Involved in tyrosine metabolic process. Predicted to be located in cytoplasmic vesicle membrane and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in thyroid gland. Human ortholog(s) of this gene implicated in t hyroid dyshormonogenesis 4. Orthologous to human IYD (iodotyrosine deiodinase). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 3490274 | 3504880 | Mouse | 170 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1345868 | IYD | iodotyrosine deiodinase | This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] | 6 | 150369012 | 150405969 | Human | 313 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8919494 | Iyd | iodotyrosine deiodinase | ENCODES a protein that exhibits FMN binding (ortholog); iodotyrosine deiodinase activity (ortholog); INVOLVED IN thyroid hormone metabolic process (ortholog); tyrosine metabolic process (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormonogenesis 4 (ortholog); FOUND IN cytoplasmic vesicle membrane (ortholog); plasma membrane (ortholog) | NW_004955439 | 10998797 | 11060078 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11906077 | IYD | iodotyrosine deiodinase | ENCODES a protein that exhibits FMN binding (inferred); iodotyrosine deiodinase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN thyroid hormone metabolic process (inferred); tyrosine metabolic process (inferred); ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormonogenesis 4 (ortholog); FOUND IN cytoplasmic vesicle membrane (inferred); plasma membrane (inferred) | 6 | 148178638 | 148216122 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12200200 | IYD | iodotyrosine deiodinase | ENCODES a protein that exhibits FMN binding (inferred); iodotyrosine deiodinase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN tyrosine metabolic process (inferred); ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormon ogenesis 4 (ortholog); FOUND IN cytoplasmic vesicle membrane (ortholog); plasma membrane (ortholog) | 1 | 40890402 | 40908437 | Dog | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12712113 | Iyd | iodotyrosine deiodinase | ENCODES a protein that exhibits FMN binding (inferred); iodotyrosine deiodinase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN thyroid hormone metabolic process (inferred); tyrosine metabolic process (inferred); ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormonogenesis 4 (ortholog); FOUND IN cytoplasmic vesicle membrane (inferred); plasma membrane (inferred) | NW_004936489 | 3454757 | 3472423 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14388124 | Iyd | | | | | | Fly | | symbol | gene, null |
| 18752060 | IYD | iodotyrosine deiodinase | ENCODES a protein that exhibits FMN binding (inferred); iodotyrosine deiodinase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN thyroid hormone metabolic process (inferred); tyrosine metabolic process (inferred); ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormonogenesis 4 (ortholog); FOUND IN cytoplasmic vesicle membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625967093 | Iyd | iodotyrosine deiodinase | ENCODES a protein that exhibits FMN binding (ortholog); iodotyrosine deiodinase activity (ortholog); INVOLVED IN thyroid hormone metabolic process (ortholog); tyrosine metabolic process (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormonogenesis 4 (ortholog); FOUND IN cytoplasmic vesicle membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14136943 | IYD | iodotyrosine deiodinase | ENCODES a protein that exhibits iodotyrosine deiodinase activity; FMN binding (ortholog); INVOLVED IN thyroid hormone metabolic process; tyrosine metabolic process; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormonogenesis 4 (ortholog); FOUND IN plasma membrane; cytoplasmic vesicle membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 32 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155250157 | iyd | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18917300 | Iyd | iodotyrosine deiodinase | ENCODES a protein that exhibits FMN binding (inferred); iodotyrosine deiodinase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN thyroid hormone metabolic process (inferred); tyrosine metabolic process (inferred); ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Liver Cirrhosis (ortholog); thyroid dyshormonogenesis 4 (ortholog); FOUND IN cytoplasmic vesicle membrane (ortholog) | | | | Naked Mole-Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244328 | iyd.L | | | | | | African Clawed Frog | | symbol | gene, null |